DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment niki and nekl-3

DIOPT Version :9

Sequence 1:	NP_651293.1	Gene:	niki / 42959	FlyBaseID:	FBgn0045980	Length:	841	Species:	Drosophila melanogaster
Sequence 2:	NP_510080.2	Gene:	nekl-3 / 181398	WormBaseID:	WBGene00008956	Length:	302	Species:	Caenorhabditis elegans

Alignment Length:	298	Identity:	105/298 - (35%)
Similarity:	166/298 - (55%)	Gaps:	30/298 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly   101 ELANYEKVRVVGQGSFGIAILYRRKS---DGHQIVFKQINLSEL-SPPGRDLAMNEVDVFSKLHH 161
            ||...||  .:|:|.|  :.::|.:.   |.| :..|:|.:.|: ....|...:.|:|:..:|:|
Worm    21 ELFIIEK--KIGKGQF--SEVFRAQCTWVDLH-VALKKIQVFEMVDQKARQDCLKEIDLLKQLNH 80

  Fly   162 PNIVSYLGSFIKDNTLLIEMEYADGGTLAQIIA--ERQGKLHFPERYIIAVFEQISSAINYMHSE 224
            .|::.|..|||.:|.|.|.:|.|:.|.::::|.  ::.|:| .||:.|...|.|::.|:.:|||:
Worm    81 VNVIRYYASFIDNNQLNIVLELAEAGDMSRMIKHFKKGGRL-IPEKTIWKYFVQLARALAHMHSK 144

  Fly   225 NILHRDLKTANVFLNRRGIVKIGDFGISKIMNTK-IHAQTVLGTPYYFSPEMCEGKEYDNKSDIW 288
            .|:|||:|.||||:...||||:||.|:.:..::| ..|.:::|||||.|||..:...|:.|||:|
Worm   145 RIMHRDIKPANVFITGNGIVKLGDLGLGRFFSSKTTAAHSLVGTPYYMSPERIQESGYNFKSDLW 209

  Fly   289 ALGCILGEMCCLKKTFAAS--NLSELVTKIMAGNYTPVPSG-YTSGLRSLMSNLLQVEAPRRPTA 350
            :.||:|.||..|:..|...  ||..|..||....|.|:|:. |::.||.|:|..:..||.:||..
Worm   210 STGCLLYEMAALQSPFYGDKMNLYSLCKKIENCEYPPLPADIYSTQLRDLVSRCILPEASKRPET 274

  Fly   351 SEVLVYWIPLIFRSLGKNKGYSYEDDVGGPGSDQLTAP 388
            ||||              :...:.::...|..||.|.|
Worm   275 SEVL--------------QVAEHMNNYFSPSGDQSTTP 298

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
niki	NP_651293.1	STKc_Nek	104..359	CDD:270855	98/264 (37%)
		S_TKc	105..354	CDD:214567	96/258 (37%)
		ATS1	445..747	CDD:227511
nekl-3	NP_510080.2	STKc_Nek6_7	23..283	CDD:270863	98/279 (35%)
nekl-3	NP_510080.2	S_TKc	23..279	CDD:214567	98/275 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000168
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R445
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.940