DRSC/TRiP Functional Genomics Resources

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Protein Alignment niki and Nek2

DIOPT Version :9

Sequence 1:NP_651293.1 Gene:niki / 42959 FlyBaseID:FBgn0045980 Length:841 Species:Drosophila melanogaster
Sequence 2:NP_035022.2 Gene:Nek2 / 18005 MGIID:109359 Length:443 Species:Mus musculus


Alignment Length:520 Identity:147/520 - (28%)
Similarity:233/520 - (44%) Gaps:131/520 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly    77 MPNRQESLLQLSVPRETGVGVAGPELANYEKVRVVGQGSFGIAILYRRKSDGHQIVFKQINLSEL 141
            ||:|.|                     :||.:..:|.||:|.....||||||..:|:|:::...:
Mouse     1 MPSRVE---------------------DYEVLHSIGTGSYGRCQKIRRKSDGKILVWKELDYGSM 44

  Fly   142 SPPGRDLAMNEVDVFSKLHHPNIVSYLGSFI--KDNTLLIEMEYADGGTLAQIIAE-RQGKLHFP 203
            :...:.:.::||::..:|.|||||||....|  .:.||.|.|||.:||.||.:|:: .:.:.:..
Mouse    45 TEVEKQMLVSEVNLLRELKHPNIVSYYDRIIDRTNTTLYIVMEYCEGGDLASVISKGTKDRQYLE 109

  Fly   204 ERYIIAVFEQISSAINYMH-----SENILHRDLKTANVFLNRRGIVKIGDFGISKIMNTKIH--- 260
            |.:::.|..|::.|:...|     ...:||||||.|||||:.:..||:||||:::|:|   |   
Mouse   110 EEFVLRVMTQLTLALKECHRRSDGGHTVLHRDLKPANVFLDSKHNVKLGDFGLARILN---HDTS 171

  Fly   261 -AQTVLGTPYYFSPEMCEGKEYDNKSDIWALGCILGEMCCLKKTFAASNLSELVTKIMAGNYTPV 324
             |:|.:|||||.|||......|:.|||||:|||:|.|:|.|...|.|.|..||..||..|.:..:
Mouse   172 FAKTFVGTPYYMSPEQMSCLSYNEKSDIWSLGCLLYELCALMPPFTAFNQKELAGKIREGRFRRI 236

  Fly   325 PSGYTSGLRSLMSNLLQVEAPRRPTASEVLVYWIPLIFRSLGKNKGYSYEDDVGGPGSDQLTAPV 389
            |..|:.||..|::.:|.::...||:..|:|.  .|||...:.:.:..:.|......|.     |.
Mouse   237 PYRYSDGLNDLITRMLNLKDYHRPSVEEILE--SPLIADLVAEEQRRNLERRGRRSGE-----PS 294

  Fly   390 PAAAYSNVSMELELPTAQTETKQLMIADTAAPHEILEKR-------------------------S 429
            .....|.|..||:|...|.:.::..:   .|..:|||::                         |
Mouse   295 KLPDSSPVLSELKLKERQLQDREQAL---RAREDILEQKERELCIRERLAEDKLARAESLMKNYS 356

  Fly   430 VLYQLKAFGTCFSMAP-IQLPPKAVIVDVAMSDSHFVVVNEDGSAYAWGEGTHGQLGLTALEAWK 493
            :|.:.:..  |.:..| :.||..|:...|     ||                ||:.        |
Mouse   357 LLKEHRLL--CLAGGPELDLPSSAMKKKV-----HF----------------HGES--------K 390

  Fly   494 HYPSRMESVRNYHVVSACAGDGFTILVTQAGSLLSCGSNAHLALGQDEQRNYHSPKLIAR-LADV 557
            ...:|.|:..:|...|.|                           :|.::..|:.:|.|: |||:
Mouse   391 ENTARSENSESYLAKSKC---------------------------RDLKKRLHAAQLRAQALADI 428

  Fly   558  557
            Mouse   429  428

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
nikiNP_651293.1 STKc_Nek 104..359 CDD:270855 102/266 (38%)
S_TKc 105..354 CDD:214567 101/260 (39%)
ATS1 445..747 CDD:227511 22/115 (19%)
Nek2NP_035022.2 STKc_Nek2 7..271 CDD:270857 103/268 (38%)
S_TKc 8..271 CDD:214567 103/267 (39%)
Interaction with PCNT. /evidence=ECO:0000250 264..443 43/233 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 282..303 4/25 (16%)
Interaction with CEP85. /evidence=ECO:0000250|UniProtKB:P51955 301..443 34/189 (18%)
Leucine-zipper 306..334 7/30 (23%)
Necessary for interaction with MAD1L1. /evidence=ECO:0000250 329..443 25/158 (16%)
Required for microtubule binding and for localization to the centrosomes. /evidence=ECO:0000250 333..370 3/38 (8%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 383..402 8/47 (17%)
Interaction with SAV1 and STK3/MST2. /evidence=ECO:0000250 402..437 10/54 (19%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000168
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R445
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
43.940

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