DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment niki and glo-4

DIOPT Version :9

Sequence 1:	NP_651293.1	Gene:	niki / 42959	FlyBaseID:	FBgn0045980	Length:	841	Species:	Drosophila melanogaster
Sequence 2:	NP_505392.3	Gene:	glo-4 / 179306	WormBaseID:	WBGene00017195	Length:	1386	Species:	Caenorhabditis elegans

Alignment Length:	944	Identity:	177/944 - (18%)
Similarity:	314/944 - (33%)	Gaps:	311/944 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    63 STSLAEAMSSSKAQMPNRQESLLQLSVPRETGVGVAGPELAN-YEKVRVVGQGSFGIAILYRRKS 126
            |.|:|:..::.:......|.:|:...:.......:...||:. |...:.:......:...:..:|
Worm   430 SKSVAQVANACRIDTAEFQSALIPNLLSTRKNRQLTNKELSQIYSIAKAINLSMSDLLKAFENES 494

  Fly   127 DGHQIVFKQINLSELSPPGRD-LAMNEVDVFSKLHHPNIVSYLGSFIKDNTLLIEMEYADGGTLA 190
            .|.|::.:.:|..:.:|...| |....|::|.|    ..:|..|:..|
Worm   495 IGEQLLPEVLNTIQTNPAKHDNLMQRVVEMFVK----RSLSAEGNMDK----------------- 538

  Fly   191 QIIAERQGKLHFPERYIIAVFEQISSAINYMHSENILHRDLKTANVFLNRRGIVKIGDFGISKIM 255
              |.|...:|.                 |::.....||            :|.|.....|:.|..
Worm   539 --IREYDAELS-----------------NFLARHEHLH------------KGSVDCAKAGMWKCT 572

  Fly   256 NTKIHAQTVLGTPYYFSPEMCEGKEYD-----------NKSDIW------------ALGCIL--- 294
            .|.:..            ::.|.|..|           |:..||            :|.|.|
Worm   573 QTLVRR------------DVHETKSIDTSTEVLLYIIKNRLQIWNEANSTDRLQIMSLVCHLDWS 625

  Fly   295 -------GEMCCL----KKTFAASNLSELVTKIMAGNYTPVPSGYTSGLRSLMSNLLQVEAPRRP 348
                   ..:|.:    ::..:..:..|:..:|...|....|.  ...:.||:|: :.:.:.::.
Worm   626 KLADADGARVCAILSAWQRDISLPSYHEMCLRIAITNSDRFPR--PCQILSLVSS-IHILSEKKI 687

  Fly   349 TASEVLVYWIPLIFRSLGKNKGYSYEDDVGGPGSDQLTAPVPAAAYSNVSMELELPTAQTETKQL 413
            :....|..::||   :.|.|.|.:..:|      |:|   :....::|....:|:|....::|:.
Worm   688 SNHANLPNFLPL---AGGNNCGATITED------DRL---MIWGNFTNAQQRMEMPQMNAKSKRS 740

  Fly   414 MIADTAAP-----------H--EILE-----KRSVLY------------QLKA-----FGTC--- 440
            ......||           |  .:||     .|::..            ||.|     ||.|
Worm   741 DSVTNGAPTLPPPAPKPEQHLPRVLEYPGGRPRAIACGAEHILVLSSSGQLSAWGGNRFGQCGVG 805

  Fly   441 --FSMAPI-----QLPPKAVIVDVAMSDSHFVVVNEDGSAYAWGEGTHGQLGLTALEAWKH---- 494
              |.:|.:     ..|   .|..:|....|...:..|||.:.:|.|..||||        |
Worm   806 HSFRIANLHQVDGDWP---AIEKIACGQFHSAFICSDGSLWTFGWGVWGQLG--------HGGRN 859

  Fly   495 -----YPSRMESVRNYHVVSACAGDGFTILVTQAGSLLSCGSNAHLALGQDEQRNYHSPKLIA-- 552
                 .|:|:..:.......|| |...|:::|..|.:|.|||.::..:|.|:.    ..|:.|
Worm   860 NSNQLVPTRVNGLICKVTQIAC-GRAHTVVLTDTGRVLVCGSGSYGQMGVDDD----IKKVFAFT 919

  Fly   553 --RLADVRVEQVAAGLQHVLALSREGAVYVWG-------------------------------TS 584
              .|..:||..:|....|.:.::.:..|:.||                               .|
Worm   920 PLPLGPLRVRDIATHYYHSICITEDNRVFEWGRNPQELKMRMFVMKKIRSAQLKNTEDPSSPSPS 984

  Fly   585 TCGALGLGNYQQQQKFPQKIL-LSHVK----TKPSKIYCGPDTSAVLFANGELHVCGSN-DYNKL 643
            |.|:....|.....:.|::.| |..||    .....:.||...||::.:.|.|:..|.. || :|
Worm   985 TNGSTPRVNLNLPAEIPREDLGLREVKHFLDGNIVSVACGLSHSALITSEGTLYTWGKGLDY-QL 1048

  Fly   644 GF-QRSAKITAFKKVQLPHKV--------TQACFSSTHSVFLVEGGYVYTMGRNAEGQRGI---R 696
            |. .::.::.       ||:|        ......:.|::...:.|.|:..|:|..||.|:   :
Worm  1049 GHGNKNERME-------PHQVFEPNGAKWVNVSLGNNHTIASTDDGSVFAWGKNDFGQCGVLTKK 1106

  Fly   697 HCNSVDHPTLVDSVKSRYIVKANCSDQCTIVASEDNIITVWGTRNG---LPGIGSTNC----GLG 754
            :.||.|       |..::..:|                     |:|   :|.:..:..    ||.
Worm  1107 NGNSAD-------VTKKFFFQA---------------------RDGRRFMPNVDESQFVQKPGLI 1143

  Fly   755 LQICTPNMELELGNN-----------TAAFTNFLASVYKSELILEPVDILALFSSKEQCDRGYYV 808
            ..:...|:. |.||.           .|:..|.:.:|  |:.:..|::.....|..|...|...:
Worm  1144 PDVRVRNLN-EDGNEGVDKEEIVDRLKASDVNVVQAV--SKHLYSPIEGKCNGSIIEDEPRNGKI 1205

  Fly   809 QVHDVY-----PLAHSVLVLVDTTTPLISSYEGD 837
            |..:.|     ||.        |||.|:....||
Worm  1206 QKQNKYDGEDGPLC--------TTTALVHLIAGD 1231

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
niki	NP_651293.1	STKc_Nek	104..359	CDD:270855	43/293 (15%)
		S_TKc	105..354	CDD:214567	42/286 (15%)
		ATS1	445..747	CDD:227511	77/371 (21%)
glo-4	NP_505392.3	RCC1_2	773..801	CDD:290274	5/27 (19%)
		RCC1_2	823..852	CDD:290274	8/28 (29%)
		RCC1	839..889	CDD:278826	16/58 (28%)
		RCC1_2	876..905	CDD:290274	10/29 (34%)
		RCC1	893..941	CDD:278826	14/51 (27%)
		RCC1_2	1018..1047	CDD:290274	9/29 (31%)
		RCC1	1034..1082	CDD:278826	11/55 (20%)
		RCC1_2	1070..1099	CDD:290274	5/28 (18%)
		VAD1-2	1303..>1371	CDD:291956
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1062377at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010