DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment niki and nekl-4

DIOPT Version :9

Sequence 1:	NP_651293.1	Gene:	niki / 42959	FlyBaseID:	FBgn0045980	Length:	841	Species:	Drosophila melanogaster
Sequence 2:	NP_498178.3	Gene:	nekl-4 / 175760	WormBaseID:	WBGene00017033	Length:	981	Species:	Caenorhabditis elegans

Alignment Length:	503	Identity:	125/503 - (24%)
Similarity:	211/503 - (41%)	Gaps:	106/503 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 TDATTLTTSSLQ------LPLGQNTQRKQSTCTRVLPT-VFT--ITDGTTGAASTSLAEAMSSSK 74
            ||.|..:...||      |.|....:|.:....:|||| :|.  :..|...:..|..
Worm   360 TDETIDSWDLLQCSIFRVLRLMYTFERSRQLLKKVLPTEIFEKFVDVGNYNSVLTDY-------- 416

  Fly    75 AQMPNRQESLLQLSV----------PRETGVGVAGPELANYEKVRVVGQGSFGIAILYRRKSDGH 129
            .|:....::|::.::          .|...||    |:..||.:..:|.|:||.....|:|:..|
Worm   417 DQIAKMYDNLIEENIEIMKDWETVNERRQAVG----EVGEYELLDQLGAGAFGCVYTVRKKAQSH 477

  Fly   130 Q------IVFKQINLSELSPPGRDLA----MNEVDVF-SKLHHPNIVSYLGSFIKDNTLLIEMEY 183
            .      :..|:|.::.|:....|.:    ::||.:. .:|.|||||.|...|::::.|.|.|:.
Worm   478 SENPAKLLALKEIFMTNLNDRESDKSFGDMISEVKIIKQQLRHPNIVRYRRIFVENHRLYIVMDL 542

  Fly   184 ADGGTLAQ-IIAERQGKLHFPERYIIAVFEQISSAINYMHSE-NILHRDLKTANVFLNRRGIVKI 246
            ..|.:|.. ||..::.|.:|.|:.|.|:..|:..|:.|:|.| .|:|||||..|:.:.....|.|
Worm   543 IQGCSLRDLIITMKEKKGNFEEKKIWAMVVQMMLALRYLHKEKQIVHRDLKPNNIMMTTDERVVI 607

  Fly   247 GDFGISKIMNTKIHAQTVLGTPYYFSPEMCEGKEYDNKSDIWALGCILGEMCCLKKTFAASNLSE 311
            .|||::|....: :.::..||..|..||:.:...|..|:|||:.||.:.|||.|:..|.::|:..
Worm   608 TDFGLAKQKGPE-YLKSAAGTIIYSCPEIVQNLPYGEKADIWSFGCCIYEMCQLQPVFHSTNMLT 671

  Fly   312 LVTKIMAGNYTPVPSGYTSGLRSLMSNLLQVEAPRRPTASEV-------LVYWIPLIFRS----- 364
            |..:|:...|.|:...::..||.|:::.|..:...||...:|       |:.::..:.|.
Worm   672 LAMQIVEAKYDPLNEMWSDDLRFLITSCLAPDPSARPDILKVSGMCGVRLLEYLDDVARQQASTS 736

  Fly   365 --LGKNKGYSYEDDVG------------GPGSDQLTA------PVPAAAYSNVSMELELPTAQTE 409
              ......|:.:.|..            .||....|:      |:..|...|.||.
Worm   737 DMTASQSSYNIKIDESPSSLNSSTSSYKRPGRSSKTSGSGKLPPINPAPRRNHSMS--------- 792

  Fly   410 TKQLMIADTAAPHEIL------EKRSVLYQLKAFGTCFSMAPIQLPPK 451
                 ..:|..|..|:      :|.||:         |..||..:|.:
Worm   793 -----AGETPRPSSIVCLPRITDKYSVM---------FPSAPSAIPSR 826

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
niki	NP_651293.1	STKc_Nek	104..359	CDD:270855	83/274 (30%)
		S_TKc	105..354	CDD:214567	82/268 (31%)
		ATS1	445..747	CDD:227511	2/7 (29%)
nekl-4	NP_498178.3	PKc_like	452..719	CDD:304357	82/267 (31%)
nekl-4	NP_498178.3	S_TKc	453..710	CDD:214567	81/257 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0589
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810