Protein Alignment niki and tbck-1

DIOPT Version :10

• Sequence 1: NP_651293.1
• Gene: niki / 42959
• FlyBaseID: FBgn0045980
• Length: 841
• Species: Drosophila melanogaster
• Sequence 2: NP_001364726.1
• Gene: tbck-1 / 173832
• WormBaseID: WBGene00016352
• Length: 839
• Species: Caenorhabditis elegans
• Alignment Length: 648
• Identity: 128/648 - (19%)
• Similarity: 243/648 - (37%)
• Gaps: 133/648 - (20%)

  Fly   115 SFGIAILYRRKSDGHQIVFKQINLSELSPPGRDLAMNEVDVFSKLHHPNIVSYL---GSFIKDNT 176
            :||..||..::.||...    ||...::.|.:.: :........|.|.|:..||   .:.|..:.
 Worm     6 NFGAFILRAQEKDGRTC----INGLPVASPAKQM-LGRFPYLQSLQHDNLSVYLHFSETVIARDL 65

  Fly   177 LLIEMEYADGGTLAQIIAERQGKLHFPERYIIAVFEQISSAINYMHSENILHRDLKTANVFL--- 238
            :::.||:.. ..|..|:  :.|.|. .|......:.:||||::|:|:.||:|..|...::::
 Worm    66 VIVVMEHYT-MNLEDIL--KTGNLK-DESLNNNFYSEISSALDYLHTRNIVHGFLHLNSIYITDR 126

  Fly   239 -NRRGIVKIGDFGISKIMNTKIHAQTVLGTPYYFSPEMCEGKEYDN------KSDIWALGCILGE 296
             |::..||:..:|:..:.|......:.:....:.:||.....| |:      :||:|.||.|:.:
 Worm   127 KNQKLSVKLSGYGLPFLTNYGKDTASSIKFGAFLAPERILNDE-DSLFAATYQSDVWELGFIILQ 190

  Fly   297 MCCLKKTFAASNLSELVTKIMAGNYTPVPSGYTSG----LRSLMSNLLQVEAPRRPTASEVLVYW 357
            :      :...:|...||:.   .|..:.:.|.:.    |.::|.:|:|:.|.::.........|
 Worm   191 I------YLGISLEAEVTET---EYLEILNKYYTDDQEKLSTVMEDLIQLLADKKRLPYHKKCEW 246

  Fly   358 IPLIFR---SLGKNKGYSYEDDVGGPGSDQLTAPVPAAAYSNVSMELELPTAQTETKQLMIADTA 419
            :..|.|   .:..:|..|..:...     ::...:.....:|...|.::.|.: |.:..:..:.|
 Worm   247 LEAIIRKCLQMCCSKRCSITEVAA-----EIEININGVKNNNNKYEYKVKTVE-EMRAAVRKEVA 305

  Fly   420 APHEILEKRSVLYQLKAFGTCFSMAPIQLPPKAVIVDVAMSDSHFVVVNED----------GSAY 474
            ..::..||.||......:.||.|...|.|..|.:|.:.|...|:..|..:|          .|.:
 Worm   306 DNNDGFEKLSVENSFYLWKTCGSTPEIILLKKGIIQNHAPISSYPTVRFDDFLRLDSGVDSQSTF 370

  Fly   475 AWGE-GTHGQLGLTALEAWKHYPSRMESVRNYHVVSACAGDGF---TILVTQAGSLLSCGS--NA 533
            .:|. ....:..||..|..:...:||     :|.:........   .||...|.::|:...  ||
 Worm   371 EYGVFDLPSKKTLTRKETGQRVSARM-----FHKIGILEDKDLLNGNILYETASNMLTVDHLLNA 430

  Fly   534 HLALGQDEQRNYHSPKLIARLADVRVEQVAAGLQHVLALSREGAVYVWGTSTCGALGLGNYQQQQ 598
            ....|        ...:|:||.::          .|:...|..   ||    |..|.:...:.:.
 Worm   431 SAVFG--------ISSIISRLTNI----------GVIPTQRAD---VW----CTLLDINETKWRD 470

  Fly   599 KFPQKILLSHVKTKPSKIYCGPDTSAVLFANGELHVCGSNDYNKLGFQRSAKI-TAFKKVQLPHK 662
            .....:|.||...:..::              ::..|...|    .:..:..| .:.:||.   |
 Worm   471 YLNLDVLASHSSDRQLEV--------------DIPRCHQYD----SYMTTPAIQESLRKVL---K 514

  Fly   663 VTQACFSSTHSVFLVEGGYVYTMGRNAEGQRGIRHCNSVDHPTLVDSVKSRYIVKANCSDQCT 725
            ..|....|.|        :||..|           |:|:..|.|:.::...::..| |..:.|
 Worm   515 GWQIVTESQH--------FVYWQG-----------CDSLATPFLLANMSKPHVAFA-CFKEFT 557

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
niki	NP_651293.1	STKc_Nek	104..359	CDD:270855	58/260 (22%)
		ATS1	433..749	CDD:444065	57/310 (18%)
tbck-1	NP_001364726.1	Protein Kinases, catalytic domain	<42..238	CDD:473864	48/209 (23%)
		TBC	444..654	CDD:214540	28/172 (16%)