Protein Alignment niki and STKLD1

DIOPT Version :9

• Sequence 1: NP_651293.1
• Gene: niki / 42959
• FlyBaseID: FBgn0045980
• Length: 841
• Species: Drosophila melanogaster
• Sequence 2: NP_714921.4
• Gene: STKLD1 / 169436
• HGNCID: 28669
• Length: 680
• Species: Homo sapiens
• Alignment Length: 792
• Identity: 172/792 - (21%)
• Similarity: 277/792 - (34%)
• Gaps: 244/792 - (30%)

  Fly    92 ETGVGVAGPELANYEKVRVVGQGSFGIAILYRRKSDGHQIVFKQIN----------LSELSPPGR 146
            |.|.|..|..:..|:.:..:..|:.|:.::........:.|.||:.          |.||.|
Human    15 ERGPGSPGEPMEKYQVLYQLNPGALGVNLVVEEMETKVKHVIKQVECMDDHYASQALEELMP--- 76

  Fly   147 DLAMNEVDVFSKLHHPNIVSYLGSFIKDN------TLLIEMEYADGGTLAQIIAERQGKLHFPER 205
                     ..||.|.:|..|...||..|      .|.:.||:.:......|..:|:.|......
Human    77 ---------LLKLRHAHISVYQELFITWNGEISSLYLCLVMEFNELSFQEVIEDKRKAKKIIDSE 132

  Fly   206 YIIAVFEQISSAINYMHSENILHRDLKTANVFLNRRGIVKIGDFGISKIMNTK----IHAQTVLG 266
            ::..|..|:..|:.|:|..:|:||:||.:|:.|......|:.|...:.:|..|    |.|:....
Human   133 WMQNVLGQVLDALEYLHHLDIIHRNLKPSNIILISSDHCKLQDLSSNVLMTDKAKWNIRAEEDPF 197

  Fly   267 TPYYFSPEMCEGKEYDNKSDIWALGCILGEM--CC---------LKKTFAASNLS-ELVTKIMAG 319
            ...:.:||.. ...:..|||||:||||:.:|  |.         |:|:...|..| :.|.|.|..
Human   198 RKSWMAPEAL-NFSFSQKSDIWSLGCIILDMTSCSFMDGTEAMHLRKSLRQSPGSLKAVLKTMEE 261

  Fly   320 NYTPVPSGYTSGLRSLMSNLLQVEAPRRPTASEVL-VYWIPLIFRSLGKNKGYSYEDDVGGPGSD 383
            ...|....:    |:|:..:||::...|.|..:|: :.::...|:|
Human   262 KQIPDVETF----RNLLPLMLQIDPSDRITIKDVVHITFLRGSFKS------------------- 303

  Fly   384 QLTAPVPAAAYSNVSMELE---LPTAQTETKQLMIADTAAPHEILEKRS--VLYQLKAFGTCFSM 443
                       |.||:.|.   :|.:.|:  .|:..:.|:..|:::|.|  ...||:|......|
Human   304 -----------SCVSLTLHRQMVPASITD--MLLEGNVASILEVMQKFSGWPEVQLRAMKRLLKM 355

  Fly   444 APIQL----PPKAVIVDVAMSDSHFVVVNEDGSAYAWGEGTHGQLGLTAL------EAWKHYP-- 496
            ...||    ||:.|.|.|...:.|..|::.             ||...:|      :|..|:|
Human   356 PADQLGLPWPPELVEVVVTTMELHDRVLDV-------------QLCACSLLLHLLGQALVHHPEA 407

  Fly   497 ---------SRMESVRNYH---------VVSACAGDGFTILVTQAGSLLSCGSNAHLALGQDEQR 543
                     |.:.|....|         |.|..|     |..||....||           :|.:
Human   408 KAPCNQAITSTLLSALQSHPEEEPLLVMVYSLLA-----ITTTQESESLS-----------EELQ 456

  Fly   544 NYHSPKLIARLADVRVEQV----------AAGLQHVLALSREGAV--------------YVWGT- 583
            |       |.|.:..:|.:          |:||..:.||..:|.:              .|..|
Human   457 N-------AGLLEHILEHLNSSLESRDVCASGLGLLWALLLDGIIVNKAPLEKVPDLISQVLATY 514

  Fly   584 --------STCGA---LGLGNYQQQQKFPQ--KILLSHVKTKPSKIYCGPDTSAVLFANGELHVC 635
                    ::||.   |.|....::|:|.|  .:||..::....:         .|..|
Human   515 PADGEMAEASCGVFWLLSLLGCIKEQQFEQVVALLLQSIRLCQDR---------ALLVN------ 564

  Fly   636 GSNDYNKL-GFQRSAKITAFK-KVQLPHKVTQACFSSTHSVFLVEGGYVYTMGRNAEGQRGIRHC 698
              |.|..| ...:.:::.||| .||.......:....|:.:...:...|..:|..      :.|.
Human   565 --NAYRGLASLVKVSELAAFKVVVQEEGGSGLSLIKETYQLHRDDPEVVENVGML------LVHL 621

  Fly   699 NSVDH--PTLVDS--------VKSRYIVKANCSDQCTIVASEDNIITVWGTRNGLPGIGSTNCGL 753
            .|.:.  |.||.|        :|.|: ..:..||....            ::.|||..||...|
Human   622 ASYEEILPELVSSSMKALLQEIKERF-TSSLVSDSSAF------------SKPGLPPGGSPQLG- 672

  Fly   754 GLQICTPNMELE 765
                ||.:..||
Human   673 ----CTTSGGLE 680

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
niki	NP_651293.1	STKc_Nek	104..359	CDD:270855	70/287 (24%)
		S_TKc	105..354	CDD:214567	69/280 (25%)
		ATS1	445..747	CDD:227511	74/381 (19%)
STKLD1	NP_714921.4	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..25		4/9 (44%)
		PKc	34..292	CDD:270622	68/274 (25%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	658..680		8/38 (21%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0589
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810