DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment niki and NEK10

DIOPT Version :9

Sequence 1:	NP_651293.1	Gene:	niki / 42959	FlyBaseID:	FBgn0045980	Length:	841	Species:	Drosophila melanogaster
Sequence 2:	NP_001381899.1	Gene:	NEK10 / 152110	HGNCID:	18592	Length:	1172	Species:	Homo sapiens

Alignment Length:	437	Identity:	117/437 - (26%)
Similarity:	194/437 - (44%)	Gaps:	71/437 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    76 QMPNRQESLLQLSVPRETGVGVAGPELANYEKVRVVGQGSFGIAILYRRKSDGHQIVFKQINLSE 140
            |:....||:.|...|.:        .:.||..:..:|.|:||.....|:.|..:.:..|::||.
Human   498 QIAENIESINQNKAPLK--------YIGNYAILDHLGSGAFGCVYKVRKHSGQNLLAMKEVNLH- 553

  Fly   141 LSPP-GRDL---------AMNEVDVF-SKLHHPNIVSYLGSFIKDNTLLIEMEYADGGTLAQIIA 194
             :|. |:|.         .::|:.:. .:|:|||||.|..:|::::.|.|.||..:|..|.:..:
Human   554 -NPAFGKDKKDRDSSVRNIVSELTIIKEQLYHPNIVRYYKTFLENDRLYIVMELIEGAPLGEHFS 617

  Fly   195 ERQGK-LHFPERYIIAVFEQISSAINYMHSE-NILHRDLKTANVFLNRRGIVKIGDFGISKIMNT 257
            ..:.| .||.|..:..:|.|:..|:.|:|.| .|:||||...|:.|..:..|.:.|||::|....
Human   618 SLKEKHHHFTEERLWKIFIQLCLALRYLHKEKRIVHRDLTPNNIMLGDKDKVTVTDFGLAKQKQE 682

  Fly   258 KIHAQTVLGTPYYFSPEMCEGKEYDNKSDIWALGCILGEMCCLKKTFAASNLSELVTKIMAGNYT 322
            .....:|:||..|..||:.:.:.|..|:|:||:||||.:|..|...|.::|:..|.|||:...|.
Human   683 NSKLTSVVGTILYSCPEVLKSEPYGEKADVWAVGCILYQMATLSPPFYSTNMLSLATKIVEAVYE 747

  Fly   323 PVPSG-YTSGLRSLMSNLLQVEAPRRPTASEVLVYWIPLIFRSLGKNKGYSYEDDVGGPGSDQLT 386
            |||.| |:..:...:|..|..:|..||...||         .|:..:....|.|::
Human   748 PVPEGIYSEKVTDTISRCLTPDAEARPDIVEV---------SSMISDVMMKYLDNL--------- 794

  Fly   387 APVPAAAYSNVSMELELPTAQTETKQ-LMIAD----------TAAPHEILEKRSVLYQLKAFGTC 440
                  :.|.:|:|.:|...:..|:: .|.|:          ....||..||.|:........:.
Human   795 ------STSQLSLEKKLERERRRTQRYFMEANRNTVTCHHELAVLSHETFEKASLSSSSSGAASL 853

  Fly   441 FS--MAPIQLPPKAV----------IVDVAMSDSHFVVVNEDGSAYA 475
            .|  .....|||:..          ..|..:||.:|.:.|.:...|:
Human   854 KSELSESADLPPEGFQASYGKDEDRACDEILSDDNFNLENAEKDTYS 900

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
niki	NP_651293.1	STKc_Nek	104..359	CDD:270855	87/268 (32%)
		S_TKc	105..354	CDD:214567	85/262 (32%)
		ATS1	445..747	CDD:227511	9/41 (22%)
NEK10	NP_001381899.1	ARM	209..251
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	855..875		4/19 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	898..954		1/3 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0589
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810