DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment niki and Herc2

DIOPT Version :9

Sequence 1:	NP_651293.1	Gene:	niki / 42959	FlyBaseID:	FBgn0045980	Length:	841	Species:	Drosophila melanogaster
Sequence 2:	NP_001347009.1	Gene:	Herc2 / 15204	MGIID:	103234	Length:	4836	Species:	Mus musculus

Alignment Length:	851	Identity:	176/851 - (20%)
Similarity:	291/851 - (34%)	Gaps:	256/851 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 KASSLPIF---NGRITDATTLTTSSLQLP----LGQNTQRKQSTCTRVLPTVFTITDGTTGAAST 64
            :.||.|:.   :...||.|: |:.::::|    |.....|:.||..|..|  .|:.||.....|.
Mouse  3608 RLSSQPVVVESSHPYTDDTS-TSGTVKIPGAEGLRVEFDRQCSTERRHDP--LTVMDGVNRIVSV 3669

  Fly    65 SLAEAMS--SSKAQMPNRQESLLQLSVPRETGVG----------VAGPELANYEKVRVVGQGSFG 117
            ......|  ||:.::|..:.....:|.....|.|          .|||
Mouse  3670 RSGREWSDWSSELRIPGDELKWKFISDGSVNGWGWRFTVYPIMPAAGP----------------- 3717

  Fly   118 IAILYRRKSDGHQIVFKQINLSE---LSPPGRDLAMNEVDVFSKLHH-----PNIVSYLGSFIKD 174
                            |.: ||:   ||.|..||....:|....|..     |.:.:.|.:..:.
Mouse  3718 ----------------KDL-LSDRCVLSCPSMDLVTCLLDFRLNLTSNRSIVPRLAASLAACAQL 3765

  Fly   175 NTL--------------LIEMEYADGGTLAQIIAERQGK---LHFPERYIIAVFEQISSAI--NY 220
            :.|              |:..|:.....:.:::.|..|:   |.|....:.|:.:.:..|:  .:
Mouse  3766 SALAASHRMWALQRLRRLLTTEFGQSININRLLGENDGESRALSFTGSALAALVKGLPEALQRQF 3830

  Fly   221 MHSENILHRDLKTANVFLNRRGIVKIGDFGISKIMNTKIHAQTVLGTPYYFSPEMCEGKEYDNKS 285
            .:.:.|:             ||                  .:.:|.:|::              .
Mouse  3831 EYEDPIV-------------RG------------------GKQLLHSPFF--------------K 3850

  Fly   286 DIWALGCILGEM----CC--------LKKTFAASNLSELVTKIMAGNYTPVPSGY----TSGLRS 334
            .:.||.|.| |:    ||        .::...||.::..:.|     .||:|..:    ...:|.
Mouse  3851 VLVALACDL-ELDTLPCCAETHKWAWFRRYCMASRVAVALDK-----RTPLPRLFLDEVAKKIRE 3909

  Fly   335 LMSN------LLQVEAPRRPTASEVLVYWIPLIFRSLGKNK------------------GYSYED 375
            ||::      |.:..:..:....|.||.|:         |:                  |:::..
Mouse  3910 LMADSESMDVLHESHSIFKREQDEQLVQWM---------NRRPDDWTLSAGGSGTIYGWGHNHRG 3965

  Fly   376 DVGGPGSDQLTAPVPAAAYSNVSMELELPTAQTETKQLMIADTAAPHEILEKRSVLYQLKAFGTC 440
            .:||....::..|.|..|.:                      |..|.:::.....|:.:.|.|..
Mouse  3966 QLGGIEGAKVKVPTPCEALA----------------------TLRPVQLIGGEQTLFAVTADGKL 4008

  Fly   441 FSMA-------------PIQLP------PKAVIVDVAMSD--SHFVVVNEDGSAYAWGEGTHGQL 484
            ::..             .:..|      ....|..||::.  .|.:.::.:|..|:|||...|:|
Mouse  4009 YATGYGAGGRLGIGGTESVSTPTLLESIQHVFIKKVAVNSGGKHCLALSSEGEVYSWGEAEDGKL 4073

  Fly   485 GLTALEAWKH-------YPSRMESVRNYHVVSACAGDGFTILVTQAGSLLSCGSNAHLALGQDEQ 542
            |        |       .|..:||:|...||...||...:..||.||.|.:.|...:..||..:.
Mouse  4074 G--------HGNRSPCDRPRVIESLRGIEVVDVAAGGAHSACVTAAGDLYTWGKGRYGRLGHSDS 4130

  Fly   543 RNYHSPKLIARLADVRVEQVAAGL--QHVLALSREGAVYVWGTSTCGALGLGNYQQQQKFPQKIL 605
            .:...|||:..|...||..:|.|.  ...|.|:.:..|:.||....|.||.|. ....|.|.||
Mouse  4131 EDQLKPKLVEALQGHRVIDIACGSGDAQTLCLTDDDTVWSWGDGDYGKLGRGG-SDGCKVPMKI- 4193

  Fly   606 LSHVKTKPSKIYCGPDTSAVLFANGELHVCGSNDYNKLGFQRSAKITAFKKVQ--LPHKVTQACF 668
            .|.......|:.||...|..|..:|.::..|..||::||......:...::||  ...||.....
Mouse  4194 DSLTGLGVVKVECGSQFSVALTKSGAVYTWGKGDYHRLGHGSDDHVRRPRQVQGLQGKKVIAIAT 4258

  Fly   669 SSTHSVFLVEGGYVYTMGRNAEGQRGIRHCNSVDHPTLVDSVKSRYIVKANCSDQCTIVASEDNI 733
            .|.|.|...|.|.|||.|.|.|||.|....|::..|.||.:::.:.:.:..|....|:
Mouse  4259 GSLHCVCCTEDGEVYTWGDNDEGQLGDGTTNAIQRPRLVAALQGKKVNRVACGSAHTL------- 4316

  Fly   734 ITVWGT 739
              .|.|
Mouse  4317 --AWST 4320

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
niki	NP_651293.1	STKc_Nek	104..359	CDD:270855	47/303 (16%)
		S_TKc	105..354	CDD:214567	44/297 (15%)
		ATS1	445..747	CDD:227511	89/314 (28%)
Herc2	NP_001347009.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	58..90
		RCC1 1-1	416..462
		RCC1 1-2	463..513
		ATS1	<494..787	CDD:227511
		RCC1 1-3	514..569
		RCC1 1-4	570..621
		RCC1 1-5	624..675
		RCC1 1-6	676..727
		RCC1 1-7	729..779
		Cyt-b5	1212..1283	CDD:365921
		MIB_HERC2	1871..1930	CDD:369043
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2351..2376
		UBA_HERC2	2461..2508	CDD:270585
		Cul7	2555..2632	CDD:371573
		SH3_15	2640..2697	CDD:375773
		ZZ_HERC2	2707..2751	CDD:239084
		APC10-HERC2	2766..2911	CDD:176485
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2928..2947
		ATS1	2957..3323	CDD:227511
		RCC1 2-1	2959..3010
		RCC1 2-2	3011..3065
		RCC1 2-3	3066..3117
		RCC1 2-4	3119..3169
		RCC1 2-5	3172..3223
		RCC1 2-6	3225..3275
		RCC1 2-7	3276..3327
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	3479..3499
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	3517..3537
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	3604..3632		7/24 (29%)
		RCC1 3-1	3953..4004		9/72 (13%)
		RCC1 3-2	4006..4058		6/51 (12%)
		ATS1	4025..4330	CDD:227511	89/315 (28%)
		RCC1 3-3	4060..4110		18/57 (32%)
		RCC1 3-4	4112..4164		15/51 (29%)
		RCC1 3-5	4166..4216		17/51 (33%)
		RCC1 3-6	4218..4268		13/49 (27%)
		RCC1 3-7	4270..4320		17/58 (29%)
		HECTc	4423..4794	CDD:238033
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	4806..4836
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1062377at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920