DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment niki and Nek8

DIOPT Version :9

Sequence 1:	NP_651293.1	Gene:	niki / 42959	FlyBaseID:	FBgn0045980	Length:	841	Species:	Drosophila melanogaster
Sequence 2:	XP_006532246.1	Gene:	Nek8 / 140859	MGIID:	1890646	Length:	702	Species:	Mus musculus

Alignment Length:	717	Identity:	236/717 - (32%)
Similarity:	344/717 - (47%)	Gaps:	130/717 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   102 LANYEKVRVVGQGSFGIAILYRRKSDGHQIVFKQINLSELSPPGRDLAMNEVDVFSKLHHPNIVS 166
            :..||::||||:|:|||..|..||:|...::.|||.:.:::...|..|.||..|...|:|||::.
Mouse     1 MEKYERIRVVGRGAFGIVHLCLRKADQKLVILKQIPVEQMTKEERQAAQNECQVLKLLNHPNVIE 65

  Fly   167 YLGSFIKDNTLLIEMEYADGGTLAQIIAERQGKLHFPERYIIAVFEQISSAINYMHSENILHRDL 231
            |..:|::|..|:|.||||.|||||:.|.:|...| ..|..|:..|.||..|::::|:..||||||
Mouse    66 YYENFLEDKALMIAMEYAPGGTLAEFIQKRCNSL-LEEETILHFFVQILLALHHVHTHLILHRDL 129

  Fly   232 KTANVFLNR-RGIVKIGDFGISKIMNTKIHAQTVLGTPYYFSPEMCEGKEYDNKSDIWALGCILG 295
            ||.|:.|:: |.:|||||||||||:::|..|.||:|||.|.|||:||||.|:.|||||||||:|.
Mouse   130 KTQNILLDKHRMVVKIGDFGISKILSSKSKAYTVVGTPCYISPELCEGKPYNQKSDIWALGCVLY 194

  Fly   296 EMCCLKKTFAASNLSELVTKIMAGNYTPVPSGYTSGLRSLMSNLLQVEAPRRPTASEVLVYWIPL 360
            |:..||:.|.|:||..||.|||:|.:.|:...|:..||.|:.:||.:|..:||..|.::..  ||
Mouse   195 ELASLKRAFEAANLPALVLKIMSGTFAPISDRYSPELRQLVLSLLSLEPAQRPPLSHIMAQ--PL 257

  Fly   361 IFRSLGKNKGYSYEDDVG-------------GP-------GSDQLTA--------------PVP- 390
            ..|:|     .:...|||             ||       ||...:|              |.|
Mouse   258 CIRAL-----LNIHTDVGSVRMRRAEKSLTPGPPIASGSTGSRATSARCRGVPRGPVRPAIPPPL 317

  Fly   391 AAAYS---NVSMELELPTAQTETKQLMIADTAAPHEILEKRSVLYQ---LKAFGTCFSMAPIQLP 449
            ::.|:   .:|..|.||...||..|:....|.........|.:|::   |.|.|.......::||
Mouse   318 SSVYAWGGGLSSPLRLPMLNTEVVQVAAGRTQKAGVTRSGRLILWEAPPLGAGGGTLLPGAVELP 382

  Fly   450 -PKAVIVDVAMSDSHFVVVNEDGSAYAWGEGTHGQLGLTALEAWKHYPSRMESVRNYHVVSACAG 513
             |:.|        |.|:               .||.|:|.    ||.              || |
Mouse   383 QPQFV--------SRFL---------------EGQSGVTI----KHV--------------AC-G 405

  Fly   514 DGFTILVTQAGSLLSCGSNAHLALGQDEQRNYHSPKLIARLADVRVEQVAAGLQHVLALSREGAV 578
            |.||..:|..|.:::.||.::..||.....:...|.::..|....:.|||.|..||||||.:|.:
Mouse   406 DLFTACLTDRGIIMTFGSGSNGCLGHGNLTDISQPTIVEALLGYEMVQVACGASHVLALSTDGEL 470

  Fly   579 YVWGTSTCGALGLGNYQQQQKFPQKILLSHVKTKPSKIYCGPDTSAVLFANGELHVCGSNDYNKL 643
            :.||....|.||||. ::....||::.::..: :..::.||.|:|.:|.:.|.:..||||.:|||
Mouse   471 FAWGRGDGGRLGLGT-RESHNCPQQVPVAPGQ-EAQRVVCGIDSSMILTSPGRVLACGSNRFNKL 533

  Fly   644 GFQRSAKITAFKKVQLPHKVTQACFSST--------------------HSVFLVEGGYVYTMGRN 688
            |...    .:..:..:|::..:...|.|                    ||..:...|..||.|.|
Mouse   534 GLDH----LSLDEEPVPYQQVEEALSFTPLGSAPLDQEPLLCVDLGTAHSAAITASGDCYTFGSN 594

  Fly   689 AEGQRGIRHCNSVDHPTLVDSVKSRYIVKANCSDQCTIVASEDNIITVW--GTRN---------G 742
            ..||.|.........|..|..::...:|...|.|..|:....:..:..|  |||.         |
Mouse   595 QHGQLGTSSRRVSRAPCRVQGLEGIKMVMVACGDAFTVAVGAEGEVYSWGKGTRGRLGRRDEDAG 659

  Fly   743 LP 744
            ||
Mouse   660 LP 661

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
niki	NP_651293.1	STKc_Nek	104..359	CDD:270855	122/255 (48%)
		S_TKc	105..354	CDD:214567	122/249 (49%)
		ATS1	445..747	CDD:227511	86/332 (26%)
Nek8	XP_006532246.1	STKc_Nek8	3..258	CDD:270859	123/257 (48%)
Nek8	XP_006532246.1	ATS1	318..663	CDD:227511	100/392 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	243	1.000	Domainoid score	I2211
eggNOG	1	0.900	-	-		E1_KOG0589
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H84442
Inparanoid	1	1.050	335	1.000	Inparanoid score	I2391
Isobase	1	0.950	-	0	Normalized mean entropy	S2769
OMA	1	1.010	-	-		QHG48158
OrthoDB	1	1.010	-	-		D1062377at2759
OrthoFinder	1	1.000	-	-		FOG0000168
OrthoInspector	1	1.000	-	-		otm43110
orthoMCL	1	0.900	-	-		OOG6_106447
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R445
SonicParanoid	1	1.000	-	-		X891
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	14	13.760