DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment niki and NEK7

DIOPT Version :9

Sequence 1:	NP_651293.1	Gene:	niki / 42959	FlyBaseID:	FBgn0045980	Length:	841	Species:	Drosophila melanogaster
Sequence 2:	XP_016855833.1	Gene:	NEK7 / 140609	HGNCID:	13386	Length:	310	Species:	Homo sapiens

Alignment Length:	297	Identity:	103/297 - (34%)
Similarity:	160/297 - (53%)	Gaps:	38/297 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    92 ETGVGVAGP------------------ELANYEKVRVVGQGSFGIAILYRRKS--DGHQIVFKQI 136
            |...|:.||                  .|||:...:.:|:|.|  :.:||...  ||..:..|::
Human     3 EQSQGMQGPPVPQFQPQKALRPDMGYNTLANFRIEKKIGRGQF--SEVYRAACLLDGVPVALKKV 65

  Fly   137 NLSEL-SPPGRDLAMNEVDVFSKLHHPNIVSYLGSFIKDNTLLIEMEYADGGTLAQIIA------ 194
            .:.:| ....|...:.|:|:..:|:|||::.|..|||:||.|.|.:|.||.|.|:::|.
Human    66 QIFDLMDAKARADCIKEIDLLKQLNHPNVIKYYASFIEDNELNIVLELADAGDLSRMIKFLFLIF 130

  Fly   195 ----ERQGKLHFPERYIIAVFEQISSAINYMHSENILHRDLKTANVFLNRRGIVKIGDFGISKIM 255
                ::|.:| .|||.:...|.|:.||:.:|||..::|||:|.||||:...|:||:||.|:.:..
Human   131 KKHFKKQKRL-IPERTVWKYFVQLCSALEHMHSRRVMHRDIKPANVFITATGVVKLGDLGLGRFF 194

  Fly   256 NTK-IHAQTVLGTPYYFSPEMCEGKEYDNKSDIWALGCILGEMCCLKKTFAAS--NLSELVTKIM 317
            ::| ..|.:::|||||.|||......|:.|||||:|||:|.||..|:..|...  ||..|..||.
Human   195 SSKTTAAHSLVGTPYYMSPERIHENGYNFKSDIWSLGCLLYEMAALQSPFYGDKMNLYSLCKKIE 259

  Fly   318 AGNYTPVPSG-YTSGLRSLMSNLLQVEAPRRPTASEV 353
            ..:|.|:||. |:..||.|::..:..:..:||..:.|
Human   260 QCDYPPLPSDHYSEELRQLVNMCINPDPEKRPDVTYV 296

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
niki	NP_651293.1	STKc_Nek	104..359	CDD:270855	97/267 (36%)
		S_TKc	105..354	CDD:214567	96/266 (36%)
		ATS1	445..747	CDD:227511
NEK7	XP_016855833.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000168
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R445
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.940