DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment niki and RCBTB2

DIOPT Version :9

Sequence 1:	NP_651293.1	Gene:	niki / 42959	FlyBaseID:	FBgn0045980	Length:	841	Species:	Drosophila melanogaster
Sequence 2:	XP_016875858.1	Gene:	RCBTB2 / 1102	HGNCID:	1914	Length:	561	Species:	Homo sapiens

Alignment Length:	435	Identity:	106/435 - (24%)
Similarity:	176/435 - (40%)	Gaps:	61/435 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   437 FGTCFSMAPIQLPPKAVIVDVAMSDSHFVVVNEDGSAYAWGEGTHGQLGLTALEAWKHYPSRMES 501
            |..| |...:||..:|.:...|.::..:..||::  .:..|....|.|||..:::... |.|::|
Human    44 FSLC-SEEELQLIRQACVFGSAGNEVLYTTVNDE--IFVLGTNCCGCLGLGDVQSTIE-PRRLDS 104

  Fly   502 VRNYHVVSACAGDG-FTILVTQAGSLLSCGSNAHLALGQDEQRNYHSP-KLIARLADVRVEQVAA 564
            :....:.....|.| ..:|.|..|.:.:.|.||:..||.....:...| .:...|::.:|.:||.
Human   105 LNGKKIACLSYGSGPHIVLATTEGEVFTWGHNAYSQLGNGTTNHGLVPCHISTNLSNKQVIEVAC 169

  Fly   565 GLQHVLALSREGAVYVWGTSTCGALGLGNYQQQQKFPQKILLSHVKTKPSKIYCGPDTSAVLFAN 629
            |..|.|.|:.:|.|:.||.:..|.:|.|: ...|..|:::...........|.||......:...
Human   170 GSYHSLVLTSDGEVFAWGYNNSGQVGSGS-TVNQPIPRRVTGCLQNKVVVTIACGQMCCMAVVDT 233

  Fly   630 GELHVCGSNDYNKLGFQRS------AKITAFKKVQLPHKVTQACFSSTHSVFLVEGGYVYTMGRN 688
            ||::|.|.|...:||...|      .::.|.:.:    :|.:......|::.|.:.|.||..|.|
Human   234 GEVYVWGYNGNGQLGLGNSGNQPTPCRVAALQGI----RVQRVACGYAHTLVLTDEGQVYAWGAN 294

  Fly   689 AEGQRGIRHCNSVDHPTLVDSVKSRYIVKANCSDQCTIVA-SEDNIITVWGTRNG----LPGIGS 748
            :.||.|..:.::..:||.|...|.|.|..|.|....|..| ::...:.:||...|    ||.:..
Human   295 SYGQLGTGNKSNQSYPTPVTVEKDRIIEIAACHSTHTSAAKTQGGHVYMWGQCRGQSVILPHLTH 359

  Fly   749 TNCGLGLQIC--TPNMELELGNNTAAFTNFLASVYKSELILEPVDILAL-------FSSKEQCDR 804
            .:|...:..|  ||.:...|                  |.:||.|.|.:       |.:.:..|.
Human   360 FSCTDDVFACFATPAVTWRL------------------LSVEPDDHLTVAESLKREFDNPDTADL 406

  Fly   805 GYYVQVHDVYPLAHSVLV----------LVDTTTPLISSYEGDYP 839
            .:.|....:|  ||.||:          |.|....::...|..||
Human   407 KFLVDGKYIY--AHKVLLKIRCEHFRSSLEDNEDDIVEMSEFSYP 449

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
niki	NP_651293.1	STKc_Nek	104..359	CDD:270855
		S_TKc	105..354	CDD:214567
		ATS1	445..747	CDD:227511	80/314 (25%)
RCBTB2	XP_016875858.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1062377at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920