DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment niki and NEK6

DIOPT Version :9

Sequence 1:	NP_651293.1	Gene:	niki / 42959	FlyBaseID:	FBgn0045980	Length:	841	Species:	Drosophila melanogaster
Sequence 2:	NP_001138473.1	Gene:	NEK6 / 10783	HGNCID:	7749	Length:	347	Species:	Homo sapiens

Alignment Length:	300	Identity:	103/300 - (34%)
Similarity:	161/300 - (53%)	Gaps:	27/300 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    60 GAASTSLAEAMSSSKAQMPNRQESLLQLSVPRETGVGVAGPELANYEKVRVVGQGSFG----IAI 120
            |.:|.:|...:.......|.|..:.|....           .||:::..:.:|:|.|.    ...
Human    45 GGSSNNLCHTLGPVHPPDPQRHPNTLSFRC-----------SLADFQIEKKIGRGQFSEVYKATC 98

  Fly   121 LYRRKSDGHQIVFKQINLSE-LSPPGRDLAMNEVDVFSKLHHPNIVSYLGSFIKDNTLLIEMEYA 184
            |..||:    :..|::.:.| :....|...:.|:.:..:|:||||:.||.|||:||.|.|.:|.|
Human    99 LLDRKT----VALKKVQIFEMMDAKARQDCVKEIGLLKQLNHPNIIKYLDSFIEDNELNIVLELA 159

  Fly   185 DGGTLAQIIA--ERQGKLHFPERYIIAVFEQISSAINYMHSENILHRDLKTANVFLNRRGIVKIG 247
            |.|.|:|:|.  ::|.:| .|||.:...|.|:.||:.:|||..::|||:|.||||:...|:||:|
Human   160 DAGDLSQMIKYFKKQKRL-IPERTVWKYFVQLCSAVEHMHSRRVMHRDIKPANVFITATGVVKLG 223

  Fly   248 DFGISKIMNTK-IHAQTVLGTPYYFSPEMCEGKEYDNKSDIWALGCILGEMCCLKKTFAAS--NL 309
            |.|:.:..::: ..|.:::|||||.|||......|:.|||||:|||:|.||..|:..|...  ||
Human   224 DLGLGRFFSSETTAAHSLVGTPYYMSPERIHENGYNFKSDIWSLGCLLYEMAALQSPFYGDKMNL 288

  Fly   310 SELVTKIMAGNYTPVP-SGYTSGLRSLMSNLLQVEAPRRP 348
            ..|..||...:|.|:| ..|:..||.|:|..:..:..:||
Human   289 FSLCQKIEQCDYPPLPGEHYSEKLRELVSMCICPDPHQRP 328

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
niki	NP_651293.1	STKc_Nek	104..359	CDD:270855	94/255 (37%)
		S_TKc	105..354	CDD:214567	94/254 (37%)
		ATS1	445..747	CDD:227511
NEK6	NP_001138473.1	STKc_Nek6	76..343	CDD:270865	96/257 (37%)
NEK6	NP_001138473.1	S_TKc	79..344	CDD:214567	94/254 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000168
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R445
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.940