DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment niki and rcc2

DIOPT Version :9

Sequence 1:	NP_651293.1	Gene:	niki / 42959	FlyBaseID:	FBgn0045980	Length:	841	Species:	Drosophila melanogaster
Sequence 2:	XP_031761501.1	Gene:	rcc2 / 100494942	XenbaseID:	XB-GENE-996297	Length:	513	Species:	Xenopus tropicalis

Alignment Length:	536	Identity:	127/536 - (23%)
Similarity:	179/536 - (33%)	Gaps:	159/536 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   372 SYEDDV-GGPGSD-------QLTAPVPAAAYSNVSMELELPTAQTETKQLMIADTAAPHE----I 424
            |.:||: |.||||       ....|...||        :.|||        :..|...|.    .
Frog    39 SDDDDLDGSPGSDGGFQGNNNKRGPAKGAA--------KAPTA--------VIVTEPEHSKEKIK 87

  Fly   425 LEKRSVLYQLKAFG-TCFSMAPIQLPPKAVIVDVAMSDSHFVVVNEDGSAY------AWGEGTHG 482
            ||......||..|| |.:.:...:..||                  ..:||      .||
Frog    88 LEGSKAKGQLLIFGATNWDLIGRKEVPK------------------QQAAYRNLGQNLWG----- 129

  Fly   483 QLGLTALEAWKHYPSRMESVRNYHVVSACAGD--GFTILVTQAGSLLSCGSNAHLALGQDEQRNY 545
                         |.|...:....|.:..||.  ..::|:|..|.|.|.|.|....||..:.:..
Frog   130 -------------PHRYGCLTGVQVRTVAAGPCAAHSLLITVEGKLWSWGRNDKGQLGHGDVKRI 181

  Fly   546 HSPKLIARLADVRVEQVAAGLQHVLALSREGAVYVWGTSTCGALGLGNYQQQQKFPQKILLSHVK 610
            ..||||..|........|.|..|.|||:..|:||.:|.:..|.|||||.......|.:||.:
Frog   182 DVPKLIESLKGEVFVHGACGRNHTLALTENGSVYAFGENKMGQLGLGNKTDAVPSPAQILYN--- 243

  Fly   611 TKP-SKIYCGPDTSAVLFANGELHVCGSNDYNKLGFQRSAKITA-------------------FK 655
            .:| :|:.||.:.|.::...|.|:..|..:|.:||.....|..|                   .:
Frog   244 GQPITKVACGAEFSMIMDCKGNLYSFGCPEYGQLGHNSDGKYIARAQRIEYDCELIARRIAIFIE 308

  Fly   656 KVQ------LPHKVTQ--ACFSSTHSVFLVEGGYVYTMGRNAEGQRGIRHCNSVDH--PTLVD-- 708
            |.:      :|:.|.:  || ...||:.|.....|::.|....|:.|  |....|.  |.||.
Frog   309 KTKDGQVLPVPNVVVRDIAC-GINHSLVLDSQKRVFSWGFGGYGRLG--HSEQRDEMVPRLVKLF 370

  Fly   709 SVKSRYIVKANCSDQCTIVASEDNIITVWGTRN-------------GLPG--IGSTNCGLGLQIC 758
            ....|...:......|:...||...:..||..|             .|.|  :.:..||....|.
Frog   371 DFPGRGASQIYAGATCSFAVSEMGGLFFWGATNTSRDSTMYPKTVQDLCGWKVRNLACGKSSIIL 435

  Fly   759 -----------TPNM-ELELGNNTAAFTNFLASVYKSELILEPVDILALFSSKEQCDRGYYVQVH 811
                       :|.. ||..|:|.|          ||....:.|..|....|.:.| .||
Frog   436 AADESTISWGPSPTFGELGYGDNKA----------KSSTTAQEVKTLDGIYSDQVC-MGY----- 484

  Fly   812 DVYPLAHSVLVLVDTT 827
                 :|:::|..|.|
Frog   485 -----SHTLVVARDET 495

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
niki	NP_651293.1	STKc_Nek	104..359	CDD:270855
		S_TKc	105..354	CDD:214567
		ATS1	445..747	CDD:227511	83/356 (23%)
rcc2	XP_031761501.1	ATS1	122..472	CDD:227511	91/383 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1062377at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920