DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment niki and stkld1

DIOPT Version :9

Sequence 1:	NP_651293.1	Gene:	niki / 42959	FlyBaseID:	FBgn0045980	Length:	841	Species:	Drosophila melanogaster
Sequence 2:	XP_031746904.1	Gene:	stkld1 / 100491915	XenbaseID:	XB-GENE-996507	Length:	608	Species:	Xenopus tropicalis

Alignment Length:	539	Identity:	139/539 - (25%)
Similarity:	224/539 - (41%)	Gaps:	96/539 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   104 NYEKVRVVGQGSFGIAILYRRKSDGHQIVFKQINLSELSPPGRDLAMNEVDVFSKLHHPNIVSYL 168
            ||..:...|.|:||.|.|........|.|.|::..  :.....:||..|.....:|.||||.:|.
Frog    21 NYRILEEWGPGTFGDACLVEELKGNTQYVIKKVEC--MDEREANLAAGEAAPLLRLRHPNICAYR 83

  Fly   169 GSFIK-DNTL-----LIEMEY-ADGGTLAQIIAERQGKLHFPERYIIAVFEQISSAINYMHSENI 226
            ..|:. ||.:     .:..:| |.|...|.:...||...:..|:.|..:..|..:|:.|:|.:|:
Frog    84 EFFVTWDNKISALFFCLATDYCAHGDVAAMVRRNRQRVQNTEEKVIQVLLGQSINALIYIHQQNL 148

  Fly   227 LHRDLKTANVFLNRRGIVKIGDFGISKIMNTKIHAQTVLGTPY--YFSPEMCEGKEYDNKSDIWA 289
            |||:||.:|:||.......|||....::::.::..:..||..:  :.:||... ..|..|||:|:
Frog   149 LHRNLKPSNIFLKDESTFLIGDLLPERLLSDEMRIEKRLGDEWRLWAAPEAMT-LTYSEKSDVWS 212

  Fly   290 LGCILGE-MCCLKKT--FAASNLSEL-VTKIMAGNYTP---VPSGYTSGLRSLMSNLLQVEAPRR 347
            |||:|.| |.|...|  ..||.|.|: ...:..|...|   ...||.:||..|:..:||:|..:|
Frog   213 LGCVLLEVMSCSLYTGEMVASLLREIRAEPLCVGKLVPTLQAIGGYPAGLCQLLPLMLQIEPEKR 277

  Fly   348 PTASEVLVYWIPLIFRSLGKNKGYSYEDDVGGPGSDQ-LTAPVPAAA---YSNVSMELELPTAQT 408
            .||.|::  .:|.:.:.|..         :|...|.| .|.|..|.|   .:.|...||.....:
Frog   278 CTAIELV--GVPYVKQCLAL---------IGSTLSGQKKTLPSGAIAELEEAGVEKTLEFMQRHS 331

  Fly   409 ETKQLMIADTAAPHEILEKRSVLYQLKAF-----GTCFSMAPIQLPPKAV-----IVDVAMSDSH 463
            :.:.   |.|||          :..|.|:     |.......|.|..:|:     .:|:.:..|.
Frog   332 DFED---AQTAA----------ISHLSAYARHPDGLGHIEEIIALVVQAMRLHCSSLDILLDGSK 383

  Fly   464 FVVVNEDGSAYAWGEGTHGQ------LGLTALEAWKHYPSRME--SVRNYHVVSACAGDGFTILV 520
            .:   :|....|...|..|:      |.:|.:.|.:.:|..|.  ||....::..|..:..|.::
Frog   384 LL---QDLLTQALEHGYEGESFTSNDLVVTLVAAARSFPHNMSLLSVIYRVIIILCTNEAATEML 445

  Fly   521 TQAGSLLS--------------CGSNAHL--ALGQDE---QR---NYHSPKLIARLA----DVRV 559
            .:||.|..              |.|...|  ::|..|   ||   ...:|:::..|:    |..|
Frog   446 GKAGFLEGVAKIMGRVLQSREMCVSCCRLLWSIGTAEGSPQRVWLELAAPRILPLLSGYMGDPPV 510

  Fly   560 EQVAAGLQHVLALSREGAV 578
            .:||.|...::.|  :|.|
Frog   511 VEVACGALWIMCL--KGCV 527

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
niki	NP_651293.1	STKc_Nek	104..359	CDD:270855	82/270 (30%)
		S_TKc	105..354	CDD:214567	81/264 (31%)
		ATS1	445..747	CDD:227511	38/173 (22%)
stkld1	XP_031746904.1	PKc_like	21..289	CDD:419665	83/272 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910