DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment niki and herc3

DIOPT Version :9

Sequence 1:	NP_651293.1	Gene:	niki / 42959	FlyBaseID:	FBgn0045980	Length:	841	Species:	Drosophila melanogaster
Sequence 2:	XP_002938676.3	Gene:	herc3 / 100488790	XenbaseID:	XB-GENE-968537	Length:	1050	Species:	Xenopus tropicalis

Alignment Length:	479	Identity:	115/479 - (24%)
Similarity:	181/479 - (37%)	Gaps:	112/479 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   445 PIQLP--PKAVIVDVAMSDSHFVVVNEDGSAYAWGEGTHGQLGLTALEAWKHYPSRMESVRNYHV 507
            |:|:.  .:..|..:|...||.:.::..|..|:||.|..||||...:|.....|..::.:....:
Frog    75 PVQVTTLTEEHITHIACGQSHNLALSYQGQLYSWGSGNDGQLGHATVEHSSRIPRIIKKLNQQKI 139

  Fly   508 VSACAGDGFTILVTQAGSLLSCGSNAHLALGQDEQ-RNYHSPKLIARLADVRVEQVAAGLQHVLA 571
            .....|:...:.:...|.|.:.|.|.|..||.... .:..||:.:..|..:.:.||.||..|..|
Frog   140 QQVSCGNDHCMALGDDGQLFTWGQNLHGQLGLGNGFLSQSSPQRVKSLEGIPLAQVTAGGSHSFA 204

  Fly   572 LSREGAVYVWGTSTCGALGLGNYQQQQKFPQKILLSHVKT----KPSKIYCGPDTSAVLFANGEL 632
            ||..|||:.||.::.|.||| |.::.::.|     .|||.    |...|.||.:.:|:|...|.|
Frog   205 LSLSGAVFGWGNNSAGQLGL-NDEKVRETP-----CHVKPLRTHKVIYISCGEEHTAILTKAGGL 263

  Fly   633 HVCGSNDYNKLGFQR-SAKITAFKKVQL-PHKVTQACFSSTHSV-FLVEGGYVYTMGRNAEGQRG 694
            ...|:....:||... :.:|...:.::| ..:|:|......|:: |:...|.:|..|....||.|
Frog   264 FTFGAGGSGQLGHDSLNNEINPRRVLELMGSEVSQIACGRQHTLAFVPSSGTLYAFGCGDLGQLG 328

  Fly   695 IRHCNSVDHPTLV-------------DSVKSRY-IVK-----AN--------------------C 720
            ..|.|:|..|.:|             .:.::.| |||     .|                    |
Frog   329 TGHKNNVKCPAVVKGKWAAHSGQISMHADRAAYNIVKQIFSGGNKTFVLCSKLESSQPADDFRFC 393

  Fly   721 SDQCTIVASEDNIITVW-------GTRNGLPGIGSTNCGL-----------------------GL 755
            |.:.......:..|.||       ...|.:.||..|...|                       |:
Frog   394 SQRNHTSVINEETIDVWRQKVLENSNTNSMNGIVQTLSSLACWNGSFLEKRNDEHFRTSPKIPGI 458

  Fly   756 QICTPNMELE----------LGNNTAAFTNFLASVYKSELILEPVDILAL--------FSSKEQC 802
            .:|:..:..|          |......|.:||.    .:|...|.|:.|:        |...:
Frog   459 NMCSIKVLFEKLMNVHHSRLLEQILKGFESFLI----PQLSSSPPDVEAMRIYIILPEFPLLQ-- 517

  Fly   803 DRGYYVQVHDVYPLAHSVLVLVDT 826
            |..||:.:  ..|||.::|.| ||
Frog   518 DSKYYITL--TLPLAMAILRL-DT 538

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
niki	NP_651293.1	STKc_Nek	104..359	CDD:270855
		S_TKc	105..354	CDD:214567
		ATS1	445..747	CDD:227511	90/357 (25%)
herc3	XP_002938676.3	RCC1	3..49	CDD:395335
		ATS1	44..353	CDD:227511	78/283 (28%)
		HECTc	702..1048	CDD:238033
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1062377at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010