DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment niki and herc6

DIOPT Version :9

Sequence 1:	NP_651293.1	Gene:	niki / 42959	FlyBaseID:	FBgn0045980	Length:	841	Species:	Drosophila melanogaster
Sequence 2:	XP_031759089.1	Gene:	herc6 / 100487734	XenbaseID:	XB-GENE-968556	Length:	1030	Species:	Xenopus tropicalis

Alignment Length:	396	Identity:	106/396 - (26%)
Similarity:	164/396 - (41%)	Gaps:	61/396 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   457 VAMSDSHFVVVNEDGSAYAWGEGTHGQLGLTALEAWKHYPSRMESVRNYH---VVSACAGDGFTI 518
            |:..:.|.:.:.|||:..:.|:..:||||.      |...|.:|.:.:..   :|....|...::
Frog    39 VSCGEKHTLYLLEDGTLLSCGQNPYGQLGR------KSNNSSIEQISSLEAQTIVDISCGTNHSV 97

  Fly   519 LVTQAGSLLSC--GSNAHLALGQDEQRNYHSPKLIARLADVRVEQVAAGLQHVLALSREGAVYVW 581
            .|:..||:.|.  ||...|..|....||: :||.|..|.:.::.|::.|..|.||||.:|.|:.|
Frog    98 AVSDEGSIYSWGDGSEGQLGTGNLSSRNF-TPKKITGLFNTKIIQISCGNFHSLALSEDGRVFSW 161

  Fly   582 GTSTCGALGLGNYQQQQKFPQKILLSHVKTKP-SKIYCGPDTSAVLFANGELHVCGSNDYNKLGF 645
            |.:.||.||||:....|..||  |:..:|..| .::..|...|..|..:|.:...|.|:..:|||
Frog   162 GQNKCGQLGLGSQIINQATPQ--LVKSLKGIPLVQVTAGGSQSFALSMSGTVFAWGKNNAGQLGF 224

  Fly   646 QRS-AKITAFKKVQLPHKVTQ---------ACFSSTHSVFLVEGGYVYTMGRNAEGQRGIRHCNS 700
            :.. .|...||    ||.|..         :| ...|:..|.:.|.|||.|.:..||.|....|.
Frog   225 KSDPMKAGTFK----PHAVNSLRNLGVAYISC-GEEHTAVLSKDGSVYTFGDDTHGQLGQNSGNQ 284

  Fly   701 VDHPTLVDSVKSRYIVKANCSDQCTI--VASEDNIITVWGTRNGLPGIGSTNCGLGLQICTPNME 763
            ...|..::....: :.:..|....|:  |.|.:.|::.        |.||.......: |:...|
Frog   285 TSVPQKIEDYAGQ-VSQVACGRYHTLLYVFSCNRIVSF--------GKGSLRPQDNTE-CSDEAE 339

  Fly   764 L--ELGNNTAAFTNFLASVYKSELIL-EPVDILALFSSKEQCDRGYYVQVHDVYPLAHSVLVLVD 825
            |  |...::...||.|..||...:.. ..|.....||.:|...|                .:|.|
Frog   340 LPSEFDISSLVPTNDLRDVYVKWIFAGNNVGFAVPFSQQEATKR----------------TLLSD 388

  Fly   826 TTTPLI 831
            |..|::
Frog   389 TFKPIL 394

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
niki	NP_651293.1	STKc_Nek	104..359	CDD:270855
		S_TKc	105..354	CDD:214567
		ATS1	445..747	CDD:227511	86/307 (28%)
herc6	XP_031759089.1	ATS1	2..373	CDD:227511	98/357 (27%)
		HUL4	324..1021	CDD:227354	20/88 (23%)
		HECTc	684..1028	CDD:238033
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1062377at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010