DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment niki and nek9

DIOPT Version :9

Sequence 1:	NP_651293.1	Gene:	niki / 42959	FlyBaseID:	FBgn0045980	Length:	841	Species:	Drosophila melanogaster
Sequence 2:	XP_021323186.1	Gene:	nek9 / 100334361	-ID:	-	Length:	921	Species:	Danio rerio

Alignment Length:	717	Identity:	224/717 - (31%)
Similarity:	346/717 - (48%)	Gaps:	115/717 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    96 GVAGPE-LANYEKVRVVGQGSFGIAILYRRKSDGHQIVFKQINLSELSPPGRDLAMNEVDVFSKL 159
            |::|.| ..:|..:||:|:|:||.|.||||..|...:|:|:|:|:.||...|...|||:.:.|.|
Zfish    31 GLSGEEDKLHYIPIRVLGKGAFGEATLYRRTEDNSLVVWKEIDLNCLSDKKRRDVMNEISILSIL 95

  Fly   160 HHPNIVSYLGSFIKDNTLLIEMEYADGGTLAQIIAERQGKLHFPERYIIAVFEQISSAINYMHSE 224
            ||.||::|...|:..||||||:||.:||.|...|.:::|.| |.|..::....||::|:.::|..
Zfish    96 HHNNIIAYFNHFLDKNTLLIELEYCNGGNLYDKINQQKGAL-FKEEVVVWYLYQIAAAVAHIHKA 159

  Fly   225 NILHRDLKTANVFLNRRGIVKIGDFGISKIMNTKIH-AQTVLGTPYYFSPEMCEGKEYDNKSDIW 288
            .|||||:||.|:||.:..::|:||:|::|.::::.. |:|.:|||||.|||:|:|.:|:.|||||
Zfish   160 GILHRDIKTLNIFLTKTNLIKLGDYGLAKKLDSQYSMAETCVGTPYYMSPELCQGVKYNFKSDIW 224

  Fly   289 ALGCILGEMCCLKKTFAASNLSELVTKIMAGNYTPVPSG--YTSGLRSLMSNLLQVEAPRRPTAS 351
            |:||:|.|:..|.:||.|:|...|..||:.||:|...:.  |||.|..|:...|..:..:||||.
Zfish   225 AMGCVLFELLTLTRTFDATNPLNLCVKIVQGNWTMEINSDVYTSELIKLVYECLDQDPEKRPTAE 289

  Fly   352 EVLVYWIPLIFRSLGKNKGYSYEDDVGGPGSDQLTAPVPAAAYSNVSMELE-----LPTAQTETK 411
            ::|..  |:|                                 |:|.:|||     |.:|..:.|
Zfish   290 QILEQ--PVI---------------------------------SHVRVELEERVAALNSAIRKPK 319

  Fly   412 QLMIADTAAPHEILEKRSVLYQLKAFGTCFSMAPIQLPPK-------AVIVDVAMSDSHFVVVNE 469
            ...:.:|:........|.|.:.   .|..|:      |.|       :....|...::||.||..
Zfish   320 LSTVTETSVAVVTTRSREVYFW---GGGKFT------PQKLDMFKGGSSAQHVCAGETHFAVVTV 375

  Fly   470 DGSAYAW-----GEGTHGQLGLTALEAWKHYPSRMESVRNYHVVSACAGDGFTILVTQAGSLLSC 529
            :...|.|     |....||||.....:::. |.|:|.::...:.....|..||..||....:...
Zfish   376 EKELYTWASVQGGAKMVGQLGHGDQASYRQ-PRRVERLQGKAIRQVSXGADFTACVTDEDQIYMF 439

  Fly   530 GSNAHLALGQDEQRNYH--SPKLIARLADVRVEQVAAGLQHVLALSREGAVYVWGTSTCGALGLG 592
            ||:.:..:|.:.:....  .|.|:....:..|.||:.|..|||||::...:|.||....|.|||.
Zfish   440 GSDYYGCVGVENELGMEVLEPVLLEFFTERAVRQVSCGDNHVLALTQSRELYAWGCGEHGRLGLD 504

  Fly   593 -----NYQQQQKFPQKILLSHVKTKPSKIYCGPDTSAVLFANGELHVCGSNDYNKLGFQRSAKIT 652
                 :...|.:.||..::       ..:|||.|.:..|..:|::..||:|::||||..:.  ||
Zfish   505 CEDDFSSPMQVEVPQGAVI-------DSVYCGSDGTFFLTESGKVLACGNNEFNKLGLNQG--IT 560

  Fly   653 AFK-------------------KVQLPHKVTQACFSSTHSVFLVEGGYVYTMGRNAEGQRGIRHC 698
            ..|                   |:....|:.......||:..:.|.|.:.|.|.|..||.|::..
Zfish   561 GIKNHPGEGYQGIPYTTTLTLVKLLSRFKIQFLAPGKTHTAAIDERGRLMTFGCNKFGQLGVKDF 625

  Fly   699 NSVDH---PTLVDSVKSRYIVKANCSDQCTIVASEDNIITVWGT----RNGLPGIGSTNCGLGLQ 756
            ..  |   ..||.....:.:.|.:|.|..||.|:|||.|..||.    |.|:|    .:.|.|.:
Zfish   626 KK--HQGVQILVGPFGGKIVTKVSCGDGFTIAATEDNQIFAWGNAGNGRLGMP----ADKGFGSE 684

  Fly   757 IC 758
            :|
Zfish   685 VC 686

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
niki	NP_651293.1	STKc_Nek	104..359	CDD:270855	111/257 (43%)
		S_TKc	105..354	CDD:214567	110/251 (44%)
		ATS1	445..747	CDD:227511	92/346 (27%)
nek9	XP_021323186.1	STKc_Nek9	40..297	CDD:270860	112/259 (43%)
nek9	XP_021323186.1	RCC1	<347..657	CDD:332518	82/327 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1062377at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.010