DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment niki and nek9

DIOPT Version :9

Sequence 1:	NP_651293.1	Gene:	niki / 42959	FlyBaseID:	FBgn0045980	Length:	841	Species:	Drosophila melanogaster
Sequence 2:	XP_012823572.1	Gene:	nek9 / 100216232	XenbaseID:	XB-GENE-974101	Length:	942	Species:	Xenopus tropicalis

Alignment Length:	726	Identity:	226/726 - (31%)
Similarity:	347/726 - (47%)	Gaps:	121/726 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    88 SVPRETGVGV--AGPEL--ANYEKVRVVGQGSFGIAILYRRKSDGHQIVFKQINLSELSPPGRDL 148
            |:..:.|..|  .|||.  .:|..:||:|.|::|.|.||||..|...:|:|::.|:.||...|..
Frog    13 SINSDFGDSVRSCGPEQEELHYIPIRVLGHGAYGEATLYRRTEDDSLVVWKEVGLARLSEKERRD 77

  Fly   149 AMNEVDVFSKLHHPNIVSYLGSFIKDNTLLIEMEYADGGTLAQIIAERQGKLHFPERYIIAVFEQ 213
            |:||:.:.|.|.|.||::|...|:..||||||:||.:||.|...|..::.:| |.|..::....|
Frog    78 ALNEIVILSLLQHDNIIAYYNHFLDSNTLLIELEYCNGGNLFDKIVRQKAQL-FQEEMVLWYLFQ 141

  Fly   214 ISSAINYMHSENILHRDLKTANVFLNRRGIVKIGDFGISKIMNTKIH-AQTVLGTPYYFSPEMCE 277
            |.||::.:|...|||||:||.|:||.:..::|:||:|::|.::::.. |:|.:||.||.|||:|:
Frog   142 IVSAVSCIHRAGILHRDIKTLNIFLTKANLIKLGDYGLAKQLSSEYSMAETCVGTLYYMSPELCQ 206

  Fly   278 GKEYDNKSDIWALGCILGEMCCLKKTFAASNLSELVTKIMAGNYTP--VPSGYTSGLRSLMSNLL 340
            |.:|..||||||:||:|.|:..|.:||.|:|...|..||:.||:..  ..|.|:..|..::...|
Frog   207 GVKYSFKSDIWAVGCVLYELLTLTRTFDATNPLNLCVKIVQGNWAMGLDNSVYSQDLIEVVHACL 271

  Fly   341 QVEAPRRPTASEVLVYWIPLIFRSLGKNKGYSYEDDVGGPGSDQLTAPVPAAAYSNVSMELELPT 405
            :.:..:||||.|:|                                 .:|..::....||.::..
Frog   272 EQDPEKRPTADEIL---------------------------------KMPILSWRRRDMEEKVSM 303

  Fly   406 AQTETKQLMIAD-TAAPHEILEKR-SVLY----------QLKAF-GTCFSMAPIQLPPKAVIVDV 457
            .....|:..... |.||..::..| |.:|          :|..| |.|.:.            .|
Frog   304 LNRSNKKPRTGTVTEAPIAVVTSRSSEVYVWGGGKTTPQKLDVFKGGCRAR------------QV 356

  Fly   458 AMSDSHFVVVNEDGSAYAW-----GEGTHGQLGLTALEAWKHYPSRMESVRNYHVVSACAGDGFT 517
            ...|:||.||..:...|.|     |...|||||.....:::. |..:|.::...|.....|..||
Frog   357 CAGDAHFAVVTVEKELYTWVNMQGGSKLHGQLGHGDRASYRQ-PKHVEKLQGKSVQQVSCGSDFT 420

  Fly   518 ILVTQAGSLLSCGSNAHLALGQDEQRNYH--SPKLIARLADVRVEQVAAGLQHVLALSREGAVYV 580
            :.::..|.|.|.||:.:..||.::.....  .|.|:....:..||||:.|..|::||:|...||.
Frog   421 VCISDEGQLYSFGSDYYGCLGVNQSAGAEVLEPLLVDFFLNEPVEQVSCGDSHIIALTRSKCVYS 485

  Fly   581 WGTSTCGALGLGNYQQQQKFPQKILLSH----VKTKPSKIYCGPDTSAVLFANGELHVCGSNDYN 641
            ||....|.|||.: :.....|||:.:..    |     .:.||.|.|.:|...|::..||.|::|
Frog   486 WGCGEYGRLGLDS-EDDVYSPQKVEVQRDLCIV-----NVCCGSDGSFLLTLTGKVLACGLNEHN 544

  Fly   642 KLGF-QRSAKI---TAFKKV----------QLP-HKVTQACFSSTHSVFLVEGGYVYTMGRNAEG 691
            |||. |.:|.|   .||::|          ||. :|:.......||:..:.|.|.:.|.|.|..|
Frog   545 KLGLNQYTAGIINHEAFQEVPYTTSLTLAKQLSFYKIRSISPGRTHTAAIDERGRLLTFGSNKCG 609

  Fly   692 QRGI----RH--CNSVDHPTLVDSVKSRYIVKANCSDQCTIVASEDNIITVWGTRNGLPGIGSTN 750
            |.|:    :|  .|.:..|     :..:.:::.:|.|:.||.|:.||.|..||           |
Frog   610 QLGVGDYRKHLGINLLGGP-----LGGKQVIRVSCGDEFTIAATADNHIFAWG-----------N 658

  Fly   751 CGLGLQICTPN 761
            .|.|....|||
Frog   659 GGNGRLAMTPN 669

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
niki	NP_651293.1	STKc_Nek	104..359	CDD:270855	105/257 (41%)
		S_TKc	105..354	CDD:214567	104/251 (41%)
		ATS1	445..747	CDD:227511	95/333 (29%)
nek9	XP_012823572.1	STKc_Nek9	33..290	CDD:270860	106/290 (37%)
nek9	XP_012823572.1	ATS1	370..708	CDD:227511	95/323 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48158
OrthoDB	1	1.010	-	-		D1062377at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm48243
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.930