DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment niki and herc5.4

DIOPT Version :9

Sequence 1:	NP_651293.1	Gene:	niki / 42959	FlyBaseID:	FBgn0045980	Length:	841	Species:	Drosophila melanogaster
Sequence 2:	XP_005160166.1	Gene:	herc5.4 / 100148091	ZFINID:	ZDB-GENE-090311-7	Length:	995	Species:	Danio rerio

Alignment Length:	377	Identity:	86/377 - (22%)
Similarity:	154/377 - (40%)	Gaps:	66/377 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   445 PIQLPPKAVIVDVAMSDSHFVVVNEDGSAYAWGEGTHGQLGLTALEAWKHYPSRMESVRNYHVVS 509
            |::......::.:|..|.|.:.::.||..:.|||.|||||||...:|....|..::|:....|..
Zfish   108 PLKSLENRQVIQIACGDQHSMALSNDGQLFVWGENTHGQLGLRKEQAGTQSPQHLQSLCEIPVAQ 172

  Fly   510 ACAGDGFTILVTQAGSLLSCGSNAHLALGQDEQRNYHSPKLIARLADVRVEQVAAGLQHVLALSR 574
            ..||...:.:::.:|.:...|||:...||..:.::...|.::..|...:...::.|.:|...||:
Zfish   173 ISAGGNHSFVLSLSGVVFGWGSNSAGQLGLGDTKDRFVPTIVKSLCGKKTVSISCGGEHTATLSK 237

  Fly   575 EGAVYVWGTSTCGALGLGNYQQQQKFPQKILLSHVKTKPSKIYCG-------PDTSAVLFANGEL 632
            .|.|:.:|:...|.|| .|..:.:..| :::.....:|.|::.||       .::|.::::.|
Zfish   238 GGTVFTFGSGGFGQLG-HNSLKDEHHP-RLIAELWGSKVSQVTCGRHHTLVFEESSKLIYSFG-- 298

  Fly   633 HVCGSNDYNKLGFQRSAKITAFKKVQLPHKVT----QACFSSTHSVFLVEGGYVYTMGRNAEGQR 693
              ||..  .:||.....|.:....|.||.:.|    :...:..|..|.:   :....|..:|..:
Zfish   299 --CGMQ--GQLGNGEQVKQSVPLPVLLPTECTEFTMEKLITGEHHSFAL---FFKNPGNESEKPK 356

  Fly   694 -----GIRHCNSVDHPTLVDSVKSRYIVKANCSDQCTIVASEDNIITVWGTRNGLPG-------- 745
                 ||.        ||.|.:..|::.:   ||....|.:|.|  ||:.:...|.|
Zfish   357 SGSNGGIL--------TLNDRMIDRWVSE---SDPWPTVKNEIN--TVFSSAASLNGSFLKTSRD 408

  Fly   746 ----IGSTNCGLGLQICTPNMELELGNNTAAFTNFLASVYKSELILEPVDIL 793
                ....:|||...:.           ..:|....||   ..||.|.|.::
Zfish   409 EHYQTSVEHCGLDFDLV-----------KTSFAKLFAS---KSLISEVVKVV 446

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
niki	NP_651293.1	STKc_Nek	104..359	CDD:270855
		S_TKc	105..354	CDD:214567
		ATS1	445..747	CDD:227511	76/329 (23%)
herc5.4	XP_005160166.1	RCC1_2	117..146	CDD:290274	10/28 (36%)
		RCC1	133..183	CDD:278826	18/49 (37%)
		RCC1	186..235	CDD:278826	10/48 (21%)
		RCC1	239..286	CDD:278826	12/48 (25%)
		RCC1	294..343	CDD:278826	12/54 (22%)
		HECTc	658..993	CDD:294058
		HECTc	682..992	CDD:214523
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1062377at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.920