DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Saf-B and SAFB2

DIOPT Version :9

Sequence 1:NP_733041.2 Gene:Saf-B / 42958 FlyBaseID:FBgn0039229 Length:928 Species:Drosophila melanogaster
Sequence 2:NP_055464.1 Gene:SAFB2 / 9667 HGNCID:21605 Length:953 Species:Homo sapiens


Alignment Length:1106 Identity:293/1106 - (26%)
Similarity:431/1106 - (38%) Gaps:403/1106 - (36%)


- Green bases have known domain annotations that are detailed below.


  Fly     3 EAG-KKIAELRVCDLKSELEKRELETVGPKAVLIERLEKSLRAEGLDPATHLIVPGAKAKKPFAM 66
            |.| ::::||||.||::||:||.|:|.|.|:||:|||:|:::.||.||....|...|.:||....
Human    24 ETGTRRLSELRVIDLRAELKKRNLDTGGNKSVLMERLKKAVKEEGQDPDEIGIELEATSKKSAKR 88

  Fly    67 PMKDLQSEVVIKEEPIDAN--EEEVKVEQQD------DYQN--------------GNDYSHHADD 109
            .:|.|:.|    ||..:.|  |::.:..|:|      :.||              .|..:....:
Human    89 CVKGLKME----EEGTEDNGLEDDSRDGQEDMEASLENLQNMGMMDMSVLDETEVANSSAPDFGE 149

  Fly   110 DG----------------------------HEIDQVG----------------DVDDECVILDDD 130
            ||                            |.:|..|                |:::.  :|:.:
Human   150 DGTDGLLDSFCDSKEYVAAQLRQLPAQPPEHAVDGEGFKNTLETSSLNFKVTPDIEES--LLEPE 212

  Fly   131 DEE---------------------------------------DEDHVYDD-EPQSGDGDAEGKAQ 155
            :|:                                       :|:.::|. .|:.||.|...::.
Human   213 NEKILDILGETCKSEPVKEESSELEQPFAQDTSSVGPDRKLAEEEDLFDSAHPEEGDLDLASEST 277

  Fly   156 DDGAENNGDD-KAIIHGE-EENTGDTGNMDNDESINLTIGEDEQKLLHD--EASDDKSIKSVKPA 216
            .....:..|. .|::..| .|..|| |...:.|.:.|....::.....:  |||.::..::...|
Human   278 AHAQSSKADSLLAVVKREPAEQPGD-GERTDCEPVGLEPAVEQSSAASELAEASSEELAEAPTEA 341

  Fly   217 NKSEKSNSKDADKKND-DGARSKKRDEKSGDKKDSSEQKSSGKSSNQ------KDDKEKSTAAPG 274
            ...|..:||:..:|.| |.........|.....:.::||.|.....:      ||:|        
Human   342 PSPEARDSKEDGRKFDFDACNEVPPAPKESSTSEGADQKMSSFKEEKDIKPIIKDEK-------- 398

  Fly   275 GATSSTASSAAGSKSGSGSSAGNGTGANSNNKQATLSRNLWVSGLSTLTRASDLKAIFSKFGKVI 339
                        .:.||||                 .|||||||||:.|||:|||.:|||:|||:
Human   399 ------------GRVGSGS-----------------GRNLWVSGLSSTTRATDLKNLFSKYGKVV 434

  Fly   340 GAKVVTNTRTPGTRCYGYVTMSSSADASRCIENLHRTELHGRIISVERTKNEIGG---------- 394
            |||||||.|:||.||||:||||:|.:|::||.:|||||||||:||||:.|||..|          
Human   435 GAKVVTNARSPGARCYGFVTMSTSDEATKCISHLHRTELHGRMISVEKAKNEPAGKKLSDRKECE 499

  Fly   395 ----SLNS-----------------KEGK-----GKAPGDAGNKKKEDDSGKKSGSGKGSSSNSG 433
                .|:|                 ||.|     .|.|.|...::|:.|..|...:.:...:.||
Human   500 VKKEKLSSVDRHHSVEIKIEKTVIKKEEKIEKKEEKKPEDIKKEEKDQDELKPGPTNRSRVTKSG 564

  Fly   434 DDKKGGDGNGDSKSVGGDLKRDGKESNRARSRRNDDRGKSLASQDRPRHDRERSAKGSQDHRSGR 498
                   ..|..::|..|                ..:|:.:.|.......:|||:| |||.:|  
Human   565 -------SRGMERTVVMD----------------KSKGEPVISVKTTSRSKERSSK-SQDRKS-- 603

  Fly   499 NPRDVDREIQQRQRERERRQREMLSYQKIREERERQRLRERERELREEERRR-REARER------ 556
                           ..:.:|::||:.||:|:|||:|.|:||||:||.|||| ||.|||      
Human   604 ---------------ESKEKRDILSFDKIKEQRERERQRQREREIRETERRREREQREREQRLEA 653

  Fly   557 --QRIEEERLQEERRKLAVERERLEREKAELLRMERERQKLER------EKIELERLELKRQQMK 613
              :|.|:.|||.||.:|..:|:|||||:.|..|:||||.::||      |:|..||.||:|||.:
Human   654 FHERKEKARLQRERLQLECQRQRLERERMERERLERERMRVERERRKEQERIHREREELRRQQEQ 718

  Fly   614 I-MESRDDPGKRGVS-KRADDRYGDVTDRKRTAIFD------APPPPRFDTNLVSSRSTYDKKHD 670
            : .|....||:|... .|.||.|.  .:.||.|:.|      ..|..||          :|..|.
Human   719 LRYEQERRPGRRPYDLDRRDDAYW--PEGKRVAMEDRYRADFPRPDHRF----------HDFDHR 771

  Fly   671 DYGSSSSTKRVLDDYSSSSKRLDYSSKRNDYSSSSGSKRGAVDDYTAVPTKRSNDYSASSSSKRD 735
            |.|...                |::..|.:     ||:                           
Human   772 DRGQYQ----------------DHAIDRRE-----GSR--------------------------- 788

  Fly   736 DYKRDEVRHLPLSGTVGGGSSSSYLHKNNTAGGGAGSYVHKNNTSGTGGRYNDSDRSNTSSYRRD 800
                      |:.|.                        |::     |..|.            |
Human   789 ----------PMMGD------------------------HRD-----GQHYG------------D 802

  Fly   801 DSHSLGN--KRYD-NSSGGGGAYGSS---SNSVNIWAPSSGGSSSHLGSGGGGGNQIKSYGNNGM 859
            |.|..|.  :|:. :|..|.|.|||.   |....:..|..||               :.:|.:..
Human   803 DRHGHGGPPERHGRDSRDGWGGYGSDKRLSEGRGLPPPPRGG---------------RDWGEHNQ 852

  Fly   860 SSNMHSTNSWQKSAPVDDNGWRQVPARFDRGYNERSTGYQGQSGGG---GAGGMYGASRPAQDRY 921
            ....|...:||  ..:|.....:..||:..|  ||  |..|.||.|   ..||:.|....||..:
Human   853 RLEEHQARAWQ--GAMDAGAASREHARWQGG--ER--GLSGPSGPGHMASRGGVAGRGGFAQGGH 911

  Fly   922 S 922
            |
Human   912 S 912

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Saf-BNP_733041.2 SAP 11..42 CDD:280251 19/30 (63%)
RRM 205..>394 CDD:223796 78/195 (40%)
RRM_SAFB_like 313..386 CDD:240863 53/72 (74%)
SWIRM-assoc_1 <588..618 CDD:293104 16/36 (44%)
SAFB2NP_055464.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..29 2/4 (50%)
SAP 30..64 CDD:128789 20/33 (61%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 91..114 7/26 (27%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 219..404 33/205 (16%)
RRM 336..>512 CDD:223796 80/212 (38%)
RRM_SAFB1_SAFB2 406..481 CDD:241123 54/74 (73%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 525..665 54/180 (30%)
Interaction with SAFB1 600..953 123/462 (27%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 684..953 80/361 (22%)
Nuclear localization signal. /evidence=ECO:0000255 713..730 6/16 (38%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165143757
Domainoid 1 1.000 114 1.000 Domainoid score I6072
eggNOG 1 0.900 - - E1_KOG4661
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 298 1.000 Inparanoid score I2724
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG46608
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0005622
OrthoInspector 1 1.000 - - otm41150
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR15683
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R1765
SonicParanoid 1 1.000 - - X1802
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1211.890

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