Protein Alignment Saf-B and SLTM

DIOPT Version :10

• Sequence 1: NP_733041.2
• Gene: Saf-B / 42958
• FlyBaseID: FBgn0039229
• Length: 928
• Species: Drosophila melanogaster
• Sequence 2: XP_011520324.2
• Gene: SLTM / 79811
• HGNCID: 20709
• Length: 1041
• Species: Homo sapiens
• Alignment Length: 1078
• Identity: 300/1078 - (27%)
• Similarity: 472/1078 - (43%)
• Gaps: 250/1078 - (23%)

  Fly     5 GKKIAELRVCDLKSELEKRELETVGPKAVLIERLEKSLRAEGLDP-------------------A 50
            ||||.:|||.||||||::|.|:..|.|.|||.||::::..||.||                   .
Human    19 GKKITDLRVIDLKSELKRRNLDITGVKTVLISRLKQAIEEEGGDPDNIELTVSTDTPNKKPTKGK 83

  Fly    51 THLIVPGAKAKKPFAMPMKDLQSEVVIKEEPIDANEEEVKVEQQDDY-QNGNDYSHHADDDG--- 111
            .|.  |....||..|   .:|..:..:::   ||..::.::|.|:.: |:|||....:::.|
Human    84 AHF--PSFAGKKHEA---DELSGDASVED---DAFIKDCELENQEAHEQDGNDELKDSEEFGENE 140

  Fly   112 ------------------HEIDQVGDVDDECVILDDDDEEDEDHVYDDEPQSGDGDAEGKAQDDG 158
                              ||:.:...::|    ::.:|.|.:    :.|.|.|:.|....|||..
Human   141 EENVHSKELLSAEENKRAHELIEAEGIED----IEKEDIESQ----EIEAQEGEDDTFLTAQDGE 197

  Fly   159 AENNGDDKAIIHGEEENT----------GDTGNMDN----------------DESINLTI----- 192
            .|.|..|   |.|..:.|          |.....|:                |::|::||
Human   198 EEENEKD---IAGSGDGTQEVSKPLPSEGSLAEADHTAHEEMEAHTTVKEAEDDNISVTIQAEDA 259

  Fly   193 ------GED------EQKLLHDEASDDKSIKSVKPANKSEKSNSKDADKKNDDGARSKKRDEKSG 245
                  |:|      ..|:...|||..|..:.....:..::|...:.:..:.||   ||.|...|
Human   260 ITLDFDGDDLLETGKNVKITDSEASKPKDGQDAIAQSPEKESKDYEMNANHKDG---KKEDCVKG 321

  Fly   246 DKKDSSEQKSSGKSSNQKDDKEKSTAAPG----GATSSTASSAAGSKSGSGSSAGN-GTGANSNN 305
            |..:...::||.|:  :..||||.|...|    ||:....||:..||....||..: |:.::::.
Human   322 DPVEKEARESSKKA--ESGDKEKDTLKKGPSSTGASGQAKSSSKESKDSKTSSKDDKGSTSSTSG 384

  Fly   306 KQATLSRNLWVSGLSTLTRASDLKAIFSKFGKVIGAKVVTNTRTPGTRCYGYVTMSSSADASRCI 370
            ...:.::|:||||||:.|:|:|||.:|.|:|||:.||||||.|:||.:|||.||||||.:.||||
Human   385 SSGSSTKNIWVSGLSSNTKAADLKNLFGKYGKVLSAKVVTNARSPGAKCYGIVTMSSSTEVSRCI 449

  Fly   371 ENLHRTELHGRIISVERTKNEIGGSLNSKEGKGKAPG-DAGNKKKEDD-SGKKSGSGKGSSSNSG 433
            .:||||||||::||||:.|.:.......||...|:.. .:|:||...| |.|...|.|.....|.
Human   450 AHLHRTELHGQLISVEKVKGDPSKKEMKKENDEKSSSRSSGDKKNTSDRSSKTQASVKKEEKRSS 514

  Fly   434 DDKKGGDGNGDSKSVGGDLKRD-GKESNRARSRRNDDRGKSLASQ--------DRPRHDRER-SA 488
            :..:..:.....|..|.|.|.| |.....:.|.:..:..|.::|:        |:.:.|..| |.
Human   515 EKSEKKESKDTKKIEGKDEKNDNGASGQTSESIKKSEEKKRISSKSPGHMVILDQTKGDHCRPSR 579

  Fly   489 KGSQDHRSGRNPRDVDREIQQRQRERERRQREMLSYQKIREERER------QRLR-----ERERE 542
            :|..:...||: ::.:|....::|:::.|::|:|.::|::|:|.|      :|||     .|.||
Human   580 RGRYEKIHGRS-KEKERASLDKKRDKDYRRKEILPFEKMKEQRLREHLVRFERLRRAMELRRRRE 643

  Fly   543 LREEERRRREARE--RQRIEEERLQEERRKLAVERERLEREKAELLRMERERQKLER------EK 599
            :.|.|||.||...  |:|.|.||||.||.:|.:||::||||:.|..|:||||.::|:      |:
Human   644 IAERERRERERIRIIREREERERLQRERERLEIERQKLERERMERERLERERIRIEQERRKEAER 708

  Fly   600 IELERLELKRQQMKIM----------------ESRDDP---GKRGVSKRADDRYGDVTD----RK 641
            |..||.||:|||.::.                ..||||   ..:.:|...|.|:|..:|    :.
Human   709 IAREREELRRQQQQLRYEQEKRNSLKRPRDVDHRRDDPYWSENKKLSLDTDARFGHGSDYSRQQN 773

  Fly   642 RTAIFDAPPPPRFDTNLVSSRSTYDKKHDDYGSSSSTK-------------RVLDDYSSSSKRLD 693
            |...||.....||..:.....|:::::....|.|...|             |...:: |.|:|.:
Human   774 RFNDFDHRERGRFPESSAVQSSSFERRDRFVGQSEGKKARPTARREDPSFERYPKNF-SDSRRNE 837

  Fly   694 YSSKRNDYSSSSGSK-RGAVDDYTAV-----------------------PTKRSNDYSASSSSKR 734
            ....||:...|...: ||..|:...|                       ||...::.|.|:..:.
Human   838 PPPPRNELRESDRREVRGERDERRTVIIHDRPDITHPRHPREAGPNPSRPTSWKSEGSMSTDKRE 902

  Fly   735 DDYKRDEVRHLPLSGTVGGGSSSSYLHKNNTAGGGAGSYVHKNNTSGTGGRYND----SDRSNTS 795
            ...:|.|.....:||             ::..|...|   ::::.||.|.|..|    :||...|
Human   903 TRVERPERSGREVSG-------------HSVRGAPPG---NRSSASGYGSREGDRGVITDRGGGS 951

  Fly   796 SYRRDDSHSLGNKRYDNSSGGGGAYGSSSNSVNIWAPSSGGSSSH----LGSGGGGGNQIKSYGN 856
            .:..::.|.:.....|.|......:|          |.|.|.|.|    :|.|..|...|..:.:
Human   952 QHYPEERHVVERHGRDTSGPRKEWHG----------PPSQGPSYHDTRRMGDGRAGAGMITQHSS 1006

  Fly   857 NGMSSN---MHSTNSWQKSAPVDDNGWRQV----PARF 887
            |....|   ..|.||..:.:   .:|::..    |.||
Human  1007 NASPINRIVQISGNSMPRGS---GSGFKPFKGGPPRRF 1041

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Saf-B	NP_733041.2	SAP	11..42	CDD:460424	18/30 (60%)
		2A1904	<16..>270	CDD:273344	79/337 (23%)
		RRM_SF	311..386	CDD:473069	49/74 (66%)
		SWIRM-assoc_1	<588..618	CDD:465142	14/51 (27%)
SLTM	XP_011520324.2	SAP	22..56	CDD:128789	19/33 (58%)
		PTZ00121	<87..730	CDD:173412	204/665 (31%)
		RRM_SLTM	392..465	CDD:410079	49/72 (68%)
		PHA03307	805..>1040	CDD:223039	52/264 (20%)