DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Saf-B and SLTM

DIOPT Version :9

Sequence 1:	NP_733041.2	Gene:	Saf-B / 42958	FlyBaseID:	FBgn0039229	Length:	928	Species:	Drosophila melanogaster
Sequence 2:	XP_011520324.1	Gene:	SLTM / 79811	HGNCID:	20709	Length:	1176	Species:	Homo sapiens

Alignment Length:	1078	Identity:	300/1078 - (27%)
Similarity:	472/1078 - (43%)	Gaps:	250/1078 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 GKKIAELRVCDLKSELEKRELETVGPKAVLIERLEKSLRAEGLDP-------------------A 50
            ||||.:|||.||||||::|.|:..|.|.|||.||::::..||.||                   .
Human   154 GKKITDLRVIDLKSELKRRNLDITGVKTVLISRLKQAIEEEGGDPDNIELTVSTDTPNKKPTKGK 218

  Fly    51 THLIVPGAKAKKPFAMPMKDLQSEVVIKEEPIDANEEEVKVEQQDDY-QNGNDYSHHADDDG--- 111
            .|.  |....||..|   .:|..:..:::   ||..::.::|.|:.: |:|||....:::.|
Human   219 AHF--PSFAGKKHEA---DELSGDASVED---DAFIKDCELENQEAHEQDGNDELKDSEEFGENE 275

  Fly   112 ------------------HEIDQVGDVDDECVILDDDDEEDEDHVYDDEPQSGDGDAEGKAQDDG 158
                              ||:.:...::|    ::.:|.|.:    :.|.|.|:.|....|||..
Human   276 EENVHSKELLSAEENKRAHELIEAEGIED----IEKEDIESQ----EIEAQEGEDDTFLTAQDGE 332

  Fly   159 AENNGDDKAIIHGEEENT----------GDTGNMDN----------------DESINLTI----- 192
            .|.|..|   |.|..:.|          |.....|:                |::|::||
Human   333 EEENEKD---IAGSGDGTQEVSKPLPSEGSLAEADHTAHEEMEAHTTVKEAEDDNISVTIQAEDA 394

  Fly   193 ------GED------EQKLLHDEASDDKSIKSVKPANKSEKSNSKDADKKNDDGARSKKRDEKSG 245
                  |:|      ..|:...|||..|..:.....:..::|...:.:..:.||   ||.|...|
Human   395 ITLDFDGDDLLETGKNVKITDSEASKPKDGQDAIAQSPEKESKDYEMNANHKDG---KKEDCVKG 456

  Fly   246 DKKDSSEQKSSGKSSNQKDDKEKSTAAPG----GATSSTASSAAGSKSGSGSSAGN-GTGANSNN 305
            |..:...::||.|:  :..||||.|...|    ||:....||:..||....||..: |:.::::.
Human   457 DPVEKEARESSKKA--ESGDKEKDTLKKGPSSTGASGQAKSSSKESKDSKTSSKDDKGSTSSTSG 519

  Fly   306 KQATLSRNLWVSGLSTLTRASDLKAIFSKFGKVIGAKVVTNTRTPGTRCYGYVTMSSSADASRCI 370
            ...:.::|:||||||:.|:|:|||.:|.|:|||:.||||||.|:||.:|||.||||||.:.||||
Human   520 SSGSSTKNIWVSGLSSNTKAADLKNLFGKYGKVLSAKVVTNARSPGAKCYGIVTMSSSTEVSRCI 584

  Fly   371 ENLHRTELHGRIISVERTKNEIGGSLNSKEGKGKAPG-DAGNKKKEDD-SGKKSGSGKGSSSNSG 433
            .:||||||||::||||:.|.:.......||...|:.. .:|:||...| |.|...|.|.....|.
Human   585 AHLHRTELHGQLISVEKVKGDPSKKEMKKENDEKSSSRSSGDKKNTSDRSSKTQASVKKEEKRSS 649

  Fly   434 DDKKGGDGNGDSKSVGGDLKRD-GKESNRARSRRNDDRGKSLASQ--------DRPRHDRER-SA 488
            :..:..:.....|..|.|.|.| |.....:.|.:..:..|.::|:        |:.:.|..| |.
Human   650 EKSEKKESKDTKKIEGKDEKNDNGASGQTSESIKKSEEKKRISSKSPGHMVILDQTKGDHCRPSR 714

  Fly   489 KGSQDHRSGRNPRDVDREIQQRQRERERRQREMLSYQKIREERER------QRLR-----ERERE 542
            :|..:...||: ::.:|....::|:::.|::|:|.::|::|:|.|      :|||     .|.||
Human   715 RGRYEKIHGRS-KEKERASLDKKRDKDYRRKEILPFEKMKEQRLREHLVRFERLRRAMELRRRRE 778

  Fly   543 LREEERRRREARE--RQRIEEERLQEERRKLAVERERLEREKAELLRMERERQKLER------EK 599
            :.|.|||.||...  |:|.|.||||.||.:|.:||::||||:.|..|:||||.::|:      |:
Human   779 IAERERRERERIRIIREREERERLQRERERLEIERQKLERERMERERLERERIRIEQERRKEAER 843

  Fly   600 IELERLELKRQQMKIM----------------ESRDDP---GKRGVSKRADDRYGDVTD----RK 641
            |..||.||:|||.::.                ..||||   ..:.:|...|.|:|..:|    :.
Human   844 IAREREELRRQQQQLRYEQEKRNSLKRPRDVDHRRDDPYWSENKKLSLDTDARFGHGSDYSRQQN 908

  Fly   642 RTAIFDAPPPPRFDTNLVSSRSTYDKKHDDYGSSSSTK-------------RVLDDYSSSSKRLD 693
            |...||.....||..:.....|:::::....|.|...|             |...:: |.|:|.:
Human   909 RFNDFDHRERGRFPESSAVQSSSFERRDRFVGQSEGKKARPTARREDPSFERYPKNF-SDSRRNE 972

  Fly   694 YSSKRNDYSSSSGSK-RGAVDDYTAV-----------------------PTKRSNDYSASSSSKR 734
            ....||:...|...: ||..|:...|                       ||...::.|.|:..:.
Human   973 PPPPRNELRESDRREVRGERDERRTVIIHDRPDITHPRHPREAGPNPSRPTSWKSEGSMSTDKRE 1037

  Fly   735 DDYKRDEVRHLPLSGTVGGGSSSSYLHKNNTAGGGAGSYVHKNNTSGTGGRYND----SDRSNTS 795
            ...:|.|.....:||             ::..|...|   ::::.||.|.|..|    :||...|
Human  1038 TRVERPERSGREVSG-------------HSVRGAPPG---NRSSASGYGSREGDRGVITDRGGGS 1086

  Fly   796 SYRRDDSHSLGNKRYDNSSGGGGAYGSSSNSVNIWAPSSGGSSSH----LGSGGGGGNQIKSYGN 856
            .:..::.|.:.....|.|......:|          |.|.|.|.|    :|.|..|...|..:.:
Human  1087 QHYPEERHVVERHGRDTSGPRKEWHG----------PPSQGPSYHDTRRMGDGRAGAGMITQHSS 1141

  Fly   857 NGMSSN---MHSTNSWQKSAPVDDNGWRQV----PARF 887
            |....|   ..|.||..:.:   .:|::..    |.||
Human  1142 NASPINRIVQISGNSMPRGS---GSGFKPFKGGPPRRF 1176

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Saf-B	NP_733041.2	SAP	11..42	CDD:280251	18/30 (60%)
		RRM	205..>394	CDD:223796	80/193 (41%)
		RRM_SAFB_like	313..386	CDD:240863	49/72 (68%)
		SWIRM-assoc_1	<588..618	CDD:293104	14/51 (27%)
SLTM	XP_011520324.1	SAP	157..191	CDD:128789	19/33 (58%)
		RRM	431..>638	CDD:223796	87/211 (41%)
		RRM_SF	527..600	CDD:302621	49/72 (68%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165143758
Domainoid	1	1.000	114	1.000	Domainoid score	I6072
eggNOG	1	0.900	-	-		E1_KOG4661
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	298	1.000	Inparanoid score	I2724
Isobase	1	0.950	-	0	Normalized mean entropy	S4174
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm41150
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR15683
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1765
SonicParanoid	1	1.000	-	-		X1802
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	13	12.830