DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Saf-B and Sltm

DIOPT Version :9

Sequence 1:	NP_733041.2	Gene:	Saf-B / 42958	FlyBaseID:	FBgn0039229	Length:	928	Species:	Drosophila melanogaster
Sequence 2:	XP_006511412.1	Gene:	Sltm / 66660	MGIID:	1913910	Length:	1053	Species:	Mus musculus

Alignment Length:	1031	Identity:	292/1031 - (28%)
Similarity:	452/1031 - (43%)	Gaps:	226/1031 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 PEAGKKIAELRVCDLKSELEKRELETVGPKAVLIERLEKSLRAEGLDPATHLIVPGAKAKKPFAM 66
            |..||||.||||.||:|||::|.|:..|.|.||:.||::::..||.||..  |........|...
Mouse   104 PAEGKKITELRVIDLRSELKRRNLDINGVKTVLVSRLKQAIEEEGGDPDN--IELTVSTDTPNKK 166

  Fly    67 PMKDLQSEVVIKEEPIDANEEEVKVEQQDDYQNGNDYSHHADDDGHEIDQVGDVDDECVILDDDD 131
            |.|....:....|...||:.|:....::.:.|.|.|.:.....||.|
Mouse   167 PTKGKGKKQEADELSGDASVEDDSFVKETEAQEGEDDTFLTAQDGEE------------------ 213

  Fly   132 EEDEDHVYDDEPQSGDGDAE--GKAQDDGAENNGDDKAIIHGEEENTGDTGNMDNDESINLTI-- 192
            ||:|    .|...||||..|  .....:|:....|..|  | ||.....||....|::|::||
Mouse   214 EENE----KDIAGSGDGTQEVSKPLPSEGSLAEADHTA--H-EEMEANATGKEAEDDNISVTIQA 271

  Fly   193 ---------GED------EQKLLHDEASDDKSIKSVKPANKSEKSNSKDADKKNDDGARSKKRDE 242
                     |:|      ..|:...|||..|.::.....:..:::...:.:..:.||   ||.|.
Mouse   272 EDAITLDFDGDDLLETGKNVKITDSEASKPKDVQDAIAQSPEKEAKDYEMNPNHKDG---KKEDS 333

  Fly   243 KSGDKKDSSEQKSSGKSSNQKDDKEKSTAAPG----GATSSTASSAAGSK---------SGSGSS 294
            ..|:..:...::|:.|:  :..||||.|...|    ||:....||:..||         .||..|
Mouse   334 VKGEPVEKEARESAKKA--ESGDKEKDTLKKGPSSTGASGQAKSSSKESKDSKTSSKDDKGSTGS 396

  Fly   295 AGNGTGANSNNKQATLSRNLWVSGLSTLTRASDLKAIFSKFGKVIGAKVVTNTRTPGTRCYGYVT 359
            ||..:|::        ::|:||||||:.|:|:|||.:|.|:|||:.||||||.|:||.:|||.||
Mouse   397 AGGSSGSS--------TKNIWVSGLSSNTKAADLKNLFGKYGKVLSAKVVTNARSPGAKCYGIVT 453

  Fly   360 MSSSADASRCIENLHRTELHGRIISVERTKNEIGGSLNSKEGKGKAPG-DAGNKKKEDDSGKKSG 423
            ||||.:.|||:.:||||||||::||||:.|.:.......||...|:.. .||:||...|...|:.
Mouse   454 MSSSTEVSRCVAHLHRTELHGQLISVEKVKGDPSKKEMKKENDEKSSSRSAGDKKNASDRSAKTQ 518

  Fly   424 SGKGSSSNSGDDKKGGDGNGDSKSVGGDLKR-DGKESNRARSRRNDDRGKSLASQDRPRH----- 482
            :..........:|.....:.|:|.:..|.|. ||.....:.|.:..:..|.::|:. |.|
Mouse   519 ASIKKEEKRSSEKSEKKESKDTKKIEKDEKNDDGPSGQTSESLKKSEEKKRISSKS-PGHMVILN 582

  Fly   483 ----DRER-SAKGSQDHRSGRNPRDVDREIQQRQRERERRQREMLSYQKIREERER------QRL 536
                |..| |.:|..:...||: ::.:|....::|:::.|::|:|.::|::|:|.|      :||
Mouse   583 QTKGDHCRPSRRGRYEKGHGRS-KEKERASLDKKRDKDYRRKEILPFEKMKEQRLREHLVRFERL 646

  Fly   537 RE-----RERELREEERRRREARE--RQRIEEERLQEERRKLAVERERLEREKAELLRMERERQK 594
            ::     |.:|:.|.|||.||...  |:|.|.||||.||.:|.:||::||||:.|..|:||||.:
Mouse   647 KQAVEFRRRKEIAERERRERERIRIIREREERERLQRERERLEIERQKLERERMERERLERERIR 711

  Fly   595 LER------EKIELERLELKRQQMKI---MESRDDPGK-RGVSKRADDRY--------------- 634
            :|:      |:|..||.||:|||.::   .|.|:...: |.|..|.||.|
Mouse   712 IEQERRREAERIAREREELRRQQQQLRYEQEKRNSLKRPRDVDHRRDDPYWSENKKLSLDTEARF 776

  Fly   635 ---GDVTDRKRTAIFDAPPPPRF-DTNLVSSRSTYDKKHDDYGSSSSTK-------------RVL 682
               .|...:.|...|......|| ||  .|.:|:::::....|.|...|             |..
Mouse   777 GHGSDYRQQSRFLDFSHRERARFPDT--ASVQSSFERRERFVGQSEGKKPRPAARREEPSFERYP 839

  Fly   683 DDYSSSSKRLDYSSKRNDYSSSSGSK-RGAVDDYTAV-----------------------PTKRS 723
            .:: |.|:|.:....||:...:...: ||..|:...|                       ||...
Mouse   840 KNF-SDSRRNEPPPPRNELRETDRREVRGERDERRTVILHDRPEVAHPRHPRETVPNPSRPTSWK 903

  Fly   724 NDYSASSSSKRDDYKRDEVRHLPLSG-TVGGGSSSSYLHKNNTAGGGAGSYVHKNNTSGTGGRYN 787
            ::.:.|:..:....:|.|.....:|| ||.|....                 ::::.||.|.|..
Mouse   904 SEANMSTEKRESRVERPERSGREVSGHTVRGAPPG-----------------NRSSASGYGTREG 951

  Fly   788 D----SDRSNTSSYRRDDSHSLGNKRYDNSSGGGGAYGSSSNSVNIWAPSSGGSSSH----LGSG 844
            :    :||.:.:.:..::.|.:.....|.|......:|          |.|.|.|.|    :|.|
Mouse   952 ERGVIADRGSGTQHYPEERHVVERHGRDTSGPRKEWHG----------PPSQGPSYHDTRRMGDG 1006

  Fly   845 GGGGNQIKSYGNNG--------MSSN---MHSTNSWQ--KSAPVDDNGWRQVPARF 887
            ..|...|..:.:..        ||.|   ..|::.::  ||.|         |.||
Mouse  1007 RAGAGMITQHSSTASPVNRIVQMSGNSLPRGSSSGFKPFKSGP---------PRRF 1053

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Saf-B	NP_733041.2	SAP	11..42	CDD:280251	16/30 (53%)
		RRM	205..>394	CDD:223796	79/201 (39%)
		RRM_SAFB_like	313..386	CDD:240863	48/72 (67%)
		SWIRM-assoc_1	<588..618	CDD:293104	15/38 (39%)
Sltm	XP_006511412.1	SAP	110..144	CDD:128789	18/33 (55%)
		PLN03124	113..>278	CDD:215591	55/191 (29%)
		RRM	348..>514	CDD:223796	78/175 (45%)
		RRM_SF	407..480	CDD:388407	48/72 (67%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167833986
Domainoid	1	1.000	114	1.000	Domainoid score	I6053
eggNOG	1	0.900	-	-		E1_KOG4661
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	297	1.000	Inparanoid score	I2702
Isobase	1	0.950	-	0	Normalized mean entropy	S4174
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm43219
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR15683
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1765
SonicParanoid	1	1.000	-	-		X1802
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	12	11.830