DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Saf-B and TRA2B

DIOPT Version :9

Sequence 1:	NP_733041.2	Gene:	Saf-B / 42958	FlyBaseID:	FBgn0039229	Length:	928	Species:	Drosophila melanogaster
Sequence 2:	NP_004584.1	Gene:	TRA2B / 6434	HGNCID:	10781	Length:	288	Species:	Homo sapiens

Alignment Length:	320	Identity:	70/320 - (21%)
Similarity:	116/320 - (36%)	Gaps:	73/320 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   220 EKSNSKDADKKNDDGARSKKRDEKSGDKKDSSEQKSSGKS-SNQKDDKEKSTAAPGGATSSTASS 283
            |..::..:...:..|..::....:|..|:||...:|..:| |..:....:|:......:.|.:.|
Human    13 ESRSASRSGSAHGSGKSARHTPARSRSKEDSRRSRSKSRSRSESRSRSRRSSRRHYTRSRSRSRS 77

  Fly   284 AAGSKSGSGSSAGNGTGANSNNKQATLSRN------------LWVSGLSTLTRASDLKAIFSKFG 336
            ...|:|.|.|.......::|::..:|..|:            |.|.|||..|...||:.:|||:|
Human    78 HRRSRSRSYSRDYRRRHSHSHSPMSTRRRHVGNRANPDPNCCLGVFGLSLYTTERDLREVFSKYG 142

  Fly   337 KVIGAKVVTNTRTPGTRCYGYVTMSSSADASRCIENLHRTELHGRIISVERTKNEIGGSLNSKEG 401
            .:....:|.:.::..:|.:.:|...:..||....|..:..||.||.|.|:.:        .:|..
Human   143 PIADVSIVYDQQSRRSRGFAFVYFENVDDAKEAKERANGMELDGRRIRVDFS--------ITKRP 199

  Fly   402 KGKAPG------DAGNKKKED--DSGKKSGSGKGSSSNSGDDK-------KGGDGNGDSKSVGGD 451
            ....||      ..|:.::.|  |.|...|.         ||:       :||.|.|
Human   200 HTPTPGIYMGRPTYGSSRRRDYYDRGYDRGY---------DDRDYYSRSYRGGGGGG-------- 247

  Fly   452 LKRDGKESNRARSRRNDDRGKSLASQDRPRHDRERSAKGSQDHRSGRNPRDVDREIQQRQ 511
                               |...|:|||.:..|.||...... |.|...|...|....|:
Human   248 -------------------GGWRAAQDRDQIYRRRSPSPYYS-RGGYRSRSRSRSYSPRR 287

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Saf-B	NP_733041.2	SAP	11..42	CDD:280251
		RRM	205..>394	CDD:223796	43/186 (23%)
		RRM_SAFB_like	313..386	CDD:240863	23/84 (27%)
		SWIRM-assoc_1	<588..618	CDD:293104
TRA2B	NP_004584.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..114		19/100 (19%)
		RRM_TRA2	117..196	CDD:409798	24/86 (28%)
		Linker	193..230		7/44 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	196..225		6/28 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	242..288		17/74 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1765
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.030