Protein Alignment Saf-B and Safb

DIOPT Version :10

• Sequence 1: NP_733041.2
• Gene: Saf-B / 42958
• FlyBaseID: FBgn0039229
• Length: 928
• Species: Drosophila melanogaster
• Sequence 2: XP_017452111.1
• Gene: Safb / 64196
• RGDID: 620613
• Length: 942
• Species: Rattus norvegicus
• Alignment Length: 1041
• Identity: 286/1041 - (27%)
• Similarity: 442/1041 - (42%)
• Gaps: 275/1041 - (26%)

  Fly     3 EAG-KKIAELRVCDLKSELEKRELETVGPKAVLIERLEKSLRAEGLDPATHLIVPGAKAKKPFAM 66
            |.| :::::|||.||::||.||.|::.|.|:||:|||:|::..||.:|....::.....|.| ..
  Rat    25 ETGTRRLSDLRVIDLRAELRKRNLDSSGNKSVLMERLKKAIEEEGGNPDEIEVISEGNKKMP-KR 88

  Fly    67 PMKDLQSEVVIKEEPIDANE-EEVKVEQQDDYQNGNDYSHHADDDGHEIDQVGDVD-DECVILDD 129
            |.|..:.|    :|.::.|. ||...:.|:|.:  ....:..|.|..:|..:.:.| |...:.|.
  Rat    89 PSKGKKPE----DEGVEDNGLEENSGDGQEDVE--TSLENLQDMDMMDISVLDEADIDNGSVADC 147

  Fly   130 DDEEDEDHVYD---DEPQSGDGDAEGKAQDDGAENNGDDKAIIHGEEENTGDTGNMDNDESINL- 190
            .:||:|..:.:   |..:..:||::| ..:...|:..|||..|:..:.::.|...:...|..:|
  Rat   148 VEEEEEATLPEGLGDSTELVEGDSKG-LPEQLQEHAIDDKEAINNVDTSSSDFTILQEMEEASLE 211

  Fly   191 --------TIGED-EQKLLHDEASD-----DKSIKSVKPANK-------SEKSNSKDADKKNDDG 234
                    .:||. :.:.:.:|.|:     .::..||.|..|       .|.....:.:::.::.
  Rat   212 PENEKILDILGETCKSEPVKEEGSELEQPFAQATSSVGPDRKLAEEEDLFESCGHPEEEEEEEEE 276

  Fly   235 ARSKKRDEKSGDKKDSSEQKSSGKSS----NQKDD-----KEKSTAAPGGAT------------- 277
            ...::..|:.||...:|..||...|:    ::.|.     |.:...||||.|
  Rat   277 EEQEEEQEEEGDLALASSSKSESSSTRCQWSEADALLAVVKREPAEAPGGGTGMDREPVGLEEPV 341

  Fly   278 --SSTAS--------------SAAGS----------------------KSGSGSSAGNGTGA--- 301
              ||||:              :||.|                      .:...|||..|...
  Rat   342 EQSSTAAQLPETTSQELVRAPTAAPSPEPRDSKDDVKKFAFDACNDVPAAPKESSASEGADQKMS 406

  Fly   302 ----NSNNK--------QATLSRNLWVSGLSTLTRASDLKAIFSKFGKVIGAKVVTNTRTPGTRC 354
                :|:.|        :::..||.||||||:.|||:|||.:||::|||:|||||||.|:||.||
  Rat   407 SVEDDSDTKRLSREEKGRSSCGRNFWVSGLSSTTRATDLKNLFSRYGKVVGAKVVTNARSPGARC 471

  Fly   355 YGYVTMSSSADASRCIENLHRTELHGRIISVERTKNEIGGSL-------NSKEGKGKAPGDAGNK 412
            ||:||||::.:|::||.:||:|||||::||||:.|:|..|..       :||:.|......:.|.
  Rat   472 YGFVTMSTAEEATKCINHLHKTELHGKMISVEKAKSEPAGKRVPDRRDGDSKKEKTSTSDRSANL 536

  Fly   413 KKED-----DSGKKSGSGKGSSSNSGDDKKGGDGNGDSKSVGGDLKRDGKESNRARSRRNDDRG- 471
            |:|:     |..||:..|....|...||:|.|                  .|.|:|:.::..||
  Rat   537 KREEKGDRKDDAKKTDDGSTEKSKDADDQKPG------------------PSERSRTTKSGSRGT 583

  Fly   472 KSLASQDRPR----------HDRERSAKGSQDHRSGRNPRDVDREIQQRQRERERRQREMLSYQK 526
            :.....|:.:          ..:||::| |||.:|      |.||           :|.::|:.|
  Rat   584 ERTVVMDKSKGVPVISVKTSGSKERASK-SQDRKS------VSRE-----------KRSVVSFDK 630

  Fly   527 IRE---ERERQRLRERERELREEERRRREARERQRIEEERLQEERRKLAVERERLEREKAELLRM 588
            ::|   .|:.:..||||||..|.|:|.:...||:  |.|||:..|.:||..|.|||||:.|..|:
  Rat   631 VKESRKSRDSESRRERERERSEREQRLQAQWERE--ERERLEIARERLAFHRHRLERERMERERL 693

  Fly   589 ERER------QKLEREKIELERLELKRQQMKIMESRDDPGKR---GVSKRADDRYGDVTDRKRTA 644
            ||||      ::.|:|:|..||.||:|||....|....|..|   .|..|.||.|.  .:.||.|
  Rat   694 ERERMHVEQERRREQERIHREREELRRQQELRYEQERRPAVRRPYEVDGRRDDAYW--PEAKRAA 756

  Fly   645 IFDAPPPPRFDTNLVSSRSTYDKKHDDYGSSSSTKRVLDDYSSSSKRLDYSSKRNDYS-SSSGSK 708
            :.|     |:.::.    |..|:.||            .|:....:..::|..|.:.| |..|.:
  Rat   757 LDD-----RYHSDF----SRQDRFHD------------FDHRDRGRYPNHSVDRREGSRSMMGDR 800

  Fly   709 RGA-VDDYTAVPTKRSNDYSASSSSKRDDYKRDEVRHLPLSGTVGGGSSSSYLHKNNTAGGGAGS 772
            .|. ..:....|.:...|       .||.:              |.||     :|..:.|.|...
  Rat   801 EGQHYPERHGGPERHGRD-------SRDGW--------------GYGS-----NKRLSEGRGLPP 839

  Fly   773 YVHKNNTSGTGGRYNDSDR-----SNTSSYRRDDSHSLGNKRYDNSSGG-------GGAYGSSSN 825
            ........|..||..:.||     ::.....||.....|.:|..:...|       ||..|..|
  Rat   840 PPRGRRDWGEHGRRLEDDRAWQGTADGGMMERDHKRWQGGERSMSGHSGPGHMMNRGGMSGRGS- 903

  Fly   826 SVNIWAPSSGGSSSHLGSGGGGGNQIKSYGNNGMSSNMHSTNSWQKSAPVDDNGWRQVPARFDRG 890
                :|| .|.|..|:...||     ...|..|.|                 .|.|...|||.|.
  Rat   904 ----FAP-GGASRGHVIPRGG-----MQAGFGGQS-----------------RGSRPSDARFTRR 941

  Fly   891 Y 891
            |
  Rat   942 Y 942

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Saf-B	NP_733041.2	SAP	11..42	CDD:460424	18/30 (60%)
		2A1904	<16..>270	CDD:273344	67/289 (23%)
		RRM_SF	311..386	CDD:473069	49/74 (66%)
		SWIRM-assoc_1	<588..618	CDD:465142	15/35 (43%)
Safb	XP_017452111.1	SAP	31..65	CDD:460424	18/33 (55%)
		PLN03124	32..>183	CDD:215591	46/158 (29%)
		RRM_SAFB1_SAFB2	428..503	CDD:410080	49/74 (66%)
		RcnB	<758..>847	CDD:444206	23/135 (17%)