Protein Alignment Saf-B and Srsf4

DIOPT Version :10

• Sequence 1: NP_733041.2
• Gene: Saf-B / 42958
• FlyBaseID: FBgn0039229
• Length: 928
• Species: Drosophila melanogaster
• Sequence 2: NP_001356237.1
• Gene: Srsf4 / 57317
• MGIID: 1890577
• Length: 496
• Species: Mus musculus
• Alignment Length: 529
• Identity: 127/529 - (24%)
• Similarity: 197/529 - (37%)
• Gaps: 133/529 - (25%)

  Fly   290 GSGSSAGNGTGANSNNKQATLSR---NLWVSGLSTLTRASDLKAIFSKFGKVIGAKVVTNTRTPG 351
            |||.| |.|...:..:|....:|   .|.|..||:.....|||....:.|:|..|..     ..|
Mouse    85 GSGRS-GYGYRRSGRDKYGPPTRTEYRLIVENLSSRCSWQDLKDYMRQAGEVTYADA-----HKG 143

  Fly   352 TRCYGYVTMSSSADASRCIENLHRTELHGRIISVERTKNEIGGSLNSKEGKGKAPGDAGNKKKED 416
            .:..|.:...|.:|..|.:|.|..||::||.|.:...|                   .|::::.
Mouse   144 RKNEGVIEFVSYSDMKRALEKLDGTEVNGRKIRLVEDK-------------------PGSRRRR- 188

  Fly   417 DSGKKSGSGKGSSSNSGDDKKGGDGNGDSKSVGGDLKRDGKESNRARSRR-NDDRGKSLA-SQDR 479
             |..:|.|...|.|.|...:|....:|.|||        ....:|:|||. :..|.||.: ||.|
Mouse   189 -SYSRSRSHSRSRSRSRHSRKSRSRSGSSKS--------SHSKSRSRSRSGSHSRSKSRSRSQSR 244

  Fly   480 PRHDRERSAKGSQDHRSGRNPRDVDREIQQRQRERERRQREMLSYQKIREERERQRLRERERELR 544
            .|..:|:|...|:|::|....|..|:   .|.:.::..:             ::.:..:...:.:
Mouse   245 SRSKKEKSRSPSKDNKSRSRSRSPDK---SRSKSKDHAE-------------DKLQNNDSAGKAK 293

  Fly   545 EEERRRREARERQRIEEERLQEERRKLAVERERLEREKAELLRMERERQKLEREKIELERLELKR 609
            .....|.:::.|.|.:|.|.:||||: :|.|.|.:         |:.|.:        |:..||.
Mouse   294 SHSPSRHDSKSRSRSQERRAEEERRR-SVSRARSQ---------EKSRSQ--------EKSLLKS 340

  Fly   610 QQMKIMESRDDPGKRGVSKRADDRYGDVTDRKRTAIFDAPPPPRFDTNLVSSRS------TYDKK 668
            :.    .||...|.|..|:..|.|.|    |||:.          |.:...|||      .:..|
Mouse   341 RS----RSRSKVGSRSRSRSKDKRKG----RKRSR----------DESRSRSRSKSERSRKHSSK 387

  Fly   669 HDDYGSSSSTKRVLD-DYSSSSKRLDYSSKRNDYSSSSGSKRGAVDDYTAVPTKRSNDYSASSSS 732
            .|...||||:|:..| |:|.|..| ..|.:|....:.||.:....:..:..|.......|.|:|.
Mouse   388 RDSKVSSSSSKKKKDTDHSRSPSR-SVSKEREHAKAESGQRESRAEGESEAPNPEPRARSRSTSK 451

  Fly   733 KRDDYKRDEVRHLPLSGTVGGGSSSSYLHKNNTAGGGAGSYVHKNNTSGTGGRYNDSDR--SNTS 795
            .:.        ::|                       |.|.....:.|.|..|.....|  |.:.
Mouse   452 SKP--------NVP-----------------------AESRSRSKSASKTRSRSKSPSRSASRSP 485

  Fly   796 SYRRDDSHS 804
            |..|..|||
Mouse   486 SRSRSRSHS 494

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Saf-B	NP_733041.2	SAP	11..42	CDD:460424
		2A1904	<16..>270	CDD:273344
		RRM_SF	311..386	CDD:473069	23/77 (30%)
		SWIRM-assoc_1	<588..618	CDD:465142	5/29 (17%)
Srsf4	NP_001356237.1	RRM_SF	<42..92	CDD:473069	5/7 (71%)
		RRM2_SRSF4_like	109..180	CDD:410012	22/75 (29%)
		U2AF_lg	250..>361	CDD:273727	31/148 (21%)