DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Saf-B and safb

DIOPT Version :9

Sequence 1:	NP_733041.2	Gene:	Saf-B / 42958	FlyBaseID:	FBgn0039229	Length:	928	Species:	Drosophila melanogaster
Sequence 2:	NP_999848.1	Gene:	safb / 321979	ZFINID:	ZDB-GENE-030131-698	Length:	855	Species:	Danio rerio

Alignment Length:	1022	Identity:	297/1022 - (29%)
Similarity:	435/1022 - (42%)	Gaps:	301/1022 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 KKIAELRVCDLKSELEKRELETVGPKAVLIERLEKSLRAEGLDP---ATHL-IVPGAKAKKPFAM 66
            :||:||||.|||:||::|.|:..|.|::|.|||:|::..||.:|   ..|| |.|   .|.|...
Zfish    17 RKISELRVIDLKAELKRRNLDISGNKSLLSERLKKAIEEEGGNPDEIVVHLDITP---KKTPRRT 78

  Fly    67 PM------KDLQSEVVIKEEPIDANEE--------------EVKVEQQDDYQNGND--------- 102
            |.      .|...:..::|:.:|..|:              ::.|..:.|..||.|
Zfish    79 PKGKRQDDHDGPEDSTLEEDSVDGQEDPDAVPENLHEMDIMDMNVLDEADMGNGGDPDEDEYDEE 143

  Fly   103 ----YSHHADDDGHEIDQVGD------VD--------DECVILDDDDEEDEDHVYDDEPQSGDGD 149
                ||:..:..|.:.|...:      ||        :|.|..||.|.::...:...|.....|:
Zfish   144 VLDTYSNEENTGGLKEDATNNCGTEDGVDIVMSKPEVEEAVEKDDADMDENQEMACQEDVGEHGN 208

  Fly   150 AEGKAQDDGAENNG--------DDKAIIHGEEE------------------NTGDTGNMDNDES- 187
            .|.|::::..:..|        ||......|||                  ||.:..|:|.:.|
Zfish   209 KEAKSEEESEKVAGSCISEPLKDDSTEELTEEEKSSVWDSHQEADNGHDLANTDEAANLDPESST 273

  Fly   188 ------------INLTIGEDEQKLLHDEASDDKSIKSVKPANKSEKSNSKDADKKNDDGARSK-- 238
                        :.||  ..:|:.:.|...|.::..:  .|:.:.::..:|.:...|....||
Zfish   274 CKLDIVASKESEVELT--NKDQENIQDSLVDAENTSA--QADNASETGLRDIESAVDSEMASKGE 334

  Fly   239 -KRDEKSGDKKDSSEQKSSGKSSNQKDDKEKSTAAPGGATSSTASSAAGSKSGSGSSAGNGTGAN 302
             ..:.||.|..:|||.|   :||.|.||::||       ....||:...||...|       ||:
Zfish   335 AVEECKSTDPAESSEVK---ESSVQGDDQKKS-------EEEDASTKPESKDDKG-------GAS 382

  Fly   303 SNNKQATLSRNLWVSGLSTLTRASDLKAIFSKFGKVIGAKVVTNTRTPGTRCYGYVTMSSSADAS 367
            |       .|||||||||:.|||:|||.:|||:|||:|||||||.|:||.||||:|||.|..:|:
Zfish   383 S-------GRNLWVSGLSSTTRATDLKNLFSKYGKVVGAKVVTNARSPGARCYGFVTMCSIEEAT 440

  Fly   368 RCIENLHRTELHGRIISVERTKNEIGGSLNSKEGKGKAPGDAGNKKKEDDSGKKSGSGKGSSSNS 432
            :||.:|||||||||:|||||.||         |..||.|.|..:.||.....:.|...|...|.:
Zfish   441 KCISHLHRTELHGRMISVERAKN---------EPAGKKPADKNDAKKSVSDRRLSSDSKTDKSEN 496

  Fly   433 GDDKKGGDGNGDSKSVGGDLKRDGKESNRARSRRNDDRGKSLASQDRPRHDRERSAKGSQDHRSG 497
            .|:|..|||.|..::|..| |..|:.....:::                 .:|||:| |:|..|
Zfish   497 KDEKTEGDGKGGERTVVMD-KSKGEPVISLKTK-----------------SKERSSK-SRDRNS- 541

  Fly   498 RNPRDVDREIQQRQRERERRQREMLSYQKIREERERQRLRERERELREEERR-----------RR 551
                            ..:.::::||:.:|:|:|||:|.|:||||:||.|||           ||
Zfish   542 ----------------LSKERKDILSFDQIKEQRERERQRQREREIREVERRRNSGERDRDRDRR 590

  Fly   552 EARERQRI---EEERLQEERRKLAVERERLEREKAELLRMERER------QKLEREKIELERLEL 607
            ..|||.|:   :||||..:|:.|.||::||:.::.|...:||||      ::.|:|:|..||.||
Zfish   591 SERERIRLFREKEERLMRKRKMLEVEKQRLDADRMEREFLERERLRVEYERRREQERIHREREEL 655

  Fly   608 KRQQMKIMESRDDPGKRGVSKRADDRYGDVTDRKRTAIFDAPPPPRFDTNLVSSRSTYDKKHDDY 672
            :|||.::...:|        :|...|..|:..||     |..|..|.:.:            |.|
Zfish   656 RRQQEQLRFEQD--------RRPVKRPYDMDGRK-----DDWPLKRMNMD------------DRY 695

  Fly   673 GSSSSTKRVLDDYSSSSKRLDYSSK-RNDYSSSSGSKRGAVDDYTAVPTKRSNDYSASSSSKRDD 736
            |.|        |:....:..|:..: ||.|.......|.  |:...:|..|.|.:    .|.||.
Zfish   696 GRS--------DFGRQDRYQDFDHRDRNRYQDDMMMDRR--DNRGGMPGDRDNQH----FSDRDR 746

  Fly   737 YKRDEVRHLPLSGTVGGGSSSSYLHKN-NTAGGGAGSYVHKNNTSGTGGRYNDSDRSNTSSYRRD 800
            :.||         ..|||   ||..:. |.|..|.|.   :.:.....||..|.||
Zfish   747 HGRD---------NWGGG---SYDKRGINPARPGPGG---RGDRDWEPGRKMDGDR--------- 787

  Fly   801 DSHSLGNKRYDNSSGGGGAYGSSSNSVNIWAPSSGGSSSHLGSGGGGGNQIKSYGNNGMSSNMHS 865
                         :..||..|         .|..|    |:..||..|.  ..|...|.|.::
Zfish   788 -------------NWQGGERG---------VPGQG----HMARGGMAGR--GGYMQAGASQSI-- 822

  Fly   866 TNSWQKSAPVDDNGWRQVPARFDRGYNERSTGYQGQSGGGGAGGMYG 912
                  |.|::.      |.:..:|     :|.||..|.|..||.:|
Zfish   823 ------SGPINR------PNQMMQG-----SGMQGGGGAGAGGGAFG 852

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Saf-B	NP_733041.2	SAP	11..42	CDD:280251	17/30 (57%)
		RRM	205..>394	CDD:223796	86/191 (45%)
		RRM_SAFB_like	313..386	CDD:240863	52/72 (72%)
		SWIRM-assoc_1	<588..618	CDD:293104	14/35 (40%)
safb	NP_999848.1	SAP	19..53	CDD:128789	19/33 (58%)
safb	NP_999848.1	RRM_SAFB1_SAFB2	384..459	CDD:241123	53/74 (72%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170576700
Domainoid	1	1.000	112	1.000	Domainoid score	I6160
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	276	1.000	Inparanoid score	I2922
OMA	1	1.010	-	-		QHG46608
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0005622
OrthoInspector	1	1.000	-	-		otm26258
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR15683
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1765
SonicParanoid	1	1.000	-	-		X1802
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	11	10.990