DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Saf-B and Safb

DIOPT Version :9

Sequence 1:NP_733041.2 Gene:Saf-B / 42958 FlyBaseID:FBgn0039229 Length:928 Species:Drosophila melanogaster
Sequence 2:NP_001361548.1 Gene:Safb / 224903 MGIID:2146974 Length:939 Species:Mus musculus


Alignment Length:1041 Identity:280/1041 - (26%)
Similarity:433/1041 - (41%) Gaps:278/1041 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly     3 EAG-KKIAELRVCDLKSELEKRELETVGPKAVLIERLEKSLRAEGLDPATHLIVPGAKAKKPFAM 66
            |.| :::::|||.||::||:||.|::.|.|:||:|||:|::..||.:|....:......|.| ..
Mouse    25 ETGTRRLSDLRVIDLRAELKKRNLDSSGNKSVLMERLKKAIEDEGGNPDEIEVTSECNKKMP-KR 88

  Fly    67 PMKDLQSEVVIKEEPIDANE-EEVKVEQQDDYQNGNDYSHHADDDGHEIDQVGDVD-DECVILDD 129
            |.|..:.|    :|.::.|. ||...:.|:|.:  ....:..|.|..:|..:.:.| |...:.|.
Mouse    89 PSKGRKPE----DEGVEDNGLEENSGDGQEDVE--TSLENLQDMDMMDISVLDEADIDNGSVADC 147

  Fly   130 DDEEDEDHVYD---DEPQSGDGDAEGKAQDDGAENNGDDKAIIHGEEENTGDTGNMDNDESINLT 191
            .:||:|..:.:   |..:..:||.:| ..:...|:..|||..::..:.::.|...:...|..:| 
Mouse   148 VEEEEEATLPEGLADSTELVEGDLKG-LPEQLQEHAIDDKDTVNNVDTSSSDFTMLQEMEEASL- 210

  Fly   192 IGEDEQKLLHDEASDDKSIKSVKPANK------SEKSNSKDADKK---NDD-----GARSKKRDE 242
              |.|.:.:.|...:....:.||....      ::.::|...|:|   .:|     |...::.:|
Mouse   211 --EPENEKILDILGETCKSEPVKEEGSELEQPFAQATSSVGPDRKLAEEEDLFESCGHPEEEEEE 273

  Fly   243 KSGDKKDSSEQK------SSGKSSNQKDD-------------KEKSTAAPGGAT----------- 277
            :..|:::..|::      ||.||.:....             |.:...||||.|           
Mouse   274 EEEDQEEEQEEEGDLALASSSKSESPSTRCQWSEADAPLAVVKREPADAPGGGTGMDREPVGLEE 338

  Fly   278 ----SSTASSAAGSKS------------------------------------GSGSSAGNGTG-- 300
                ||||:....:.|                                    ...|||..|..  
Mouse   339 PVEQSSTAAQLPEATSQELVRAPTAALSPEPQDSKEDVKKFAFDACNDVPAPPKESSASEGADQK 403

  Fly   301 -----ANSNNK--------QATLSRNLWVSGLSTLTRASDLKAIFSKFGKVIGAKVVTNTRTPGT 352
                 .:|:.|        :::..||.||||||:.|||:|||.:||::|||:|||||||.|:||.
Mouse   404 MSSVEEDSDTKRLSREEKGRSSCGRNFWVSGLSSTTRATDLKNLFSRYGKVVGAKVVTNARSPGA 468

  Fly   353 RCYGYVTMSSSADASRCIENLHRTELHGRIISVERTKNEIGGSL-------NSKEGKGKAPGDAG 410
            ||||:||||::.:|::||.:||:|||||::||||:.|:|..|..       :||:.|......:.
Mouse   469 RCYGFVTMSTAEEATKCISHLHKTELHGKMISVEKAKSEPTGKRVPDRRDGDSKKEKASTSDRSA 533

  Fly   411 NKKKED-----DSGKKSGSGKGSSSNSGDDKKGGDGNGDSKSVGGDLKRDGKESNRARSRRNDDR 470
            |.|:|:     |..||:..|....|...||:|.|                  .|.|:|:.::..|
Mouse   534 NLKREEKGERKDDAKKTDDGSTEKSKDADDQKPG------------------PSERSRTTKSGSR 580

  Fly   471 G-KSLASQDRPR----------HDRERSAKGSQDHRSGRNPRDVDREIQQRQRERERRQREMLSY 524
            | :.....|:.:          ..:||::| |||.:|.                 .|.:|.::|:
Mouse   581 GTERTVVMDKSKGVPVISVKTSGSKERASK-SQDRKSA-----------------SREKRSVVSF 627

  Fly   525 QKIREERE-RQRLRERERELREEERRRREARERQRIEEERLQEERRKLAVERERLEREKAELLRM 588
            .|::|.|: |.....||||..|.|:|.:...||:  |.|||:..|.:||..|.|||||:.|..|:
Mouse   628 DKVKESRKSRDSESRRERERSEREQRLQAQWERE--ERERLEIARERLAFHRHRLERERMERERL 690

  Fly   589 ERER------QKLEREKIELERLELKRQQMKIMESRDDPGKR---GVSKRADDRYGDVTDRKRTA 644
            ||||      ::.|:|:|..||.||:|||....|....|..|   .|..|.||.|.  .:.||.|
Mouse   691 ERERMHVEQERRREQERIHREREELRRQQELRYEQERRPAVRRPYEVDGRRDDAYW--PEAKRAA 753

  Fly   645 IFDAPPPPRFDTNLVSSRSTYDKKHDDYGSSSSTKRVLDDYSSSSKRLDYSSKRNDYS-SSSGSK 708
            :.|     |:.::.    |..|:.||            .|:....:..::|..|.:.| |..|.:
Mouse   754 LDD-----RYHSDF----SRQDRFHD------------FDHRDRGRYPNHSVDRREGSRSMMGDR 797

  Fly   709 RGA-VDDYTAVPTKRSNDYSASSSSKRDDYKRDEVRHLPLSGTVGGGSSSSYLHKNNTAGGGAGS 772
            .|. ..:....|.:...|       .||.:              |.||     :|..:.|.|...
Mouse   798 EGQHYPERHGGPERHGRD-------SRDGW--------------GYGS-----NKRLSEGRGLPP 836

  Fly   773 YVHKNNTSGTGGRYNDSDR-----SNTSSYRRDDSHSLGNKRYDNSSGG-------GGAYGSSSN 825
            ........|..||..:.||     ::.....||.....|.:|..:...|       ||..|..| 
Mouse   837 PPRGRRDWGEHGRRLEDDRAWQGTADGGMMERDHKRWQGGERSMSGHSGPGHMMNRGGMSGRGS- 900

  Fly   826 SVNIWAPSSGGSSSHLGSGGGGGNQIKSYGNNGMSSNMHSTNSWQKSAPVDDNGWRQVPARFDRG 890
                :|| .|.|..|:...||     ...|..|.|                 .|.|...|||.|.
Mouse   901 ----FAP-GGASRGHVIPRGG-----MQAGFGGQS-----------------RGSRPSDARFTRR 938

  Fly   891 Y 891
            |
Mouse   939 Y 939

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Saf-BNP_733041.2 SAP 11..42 CDD:280251 18/30 (60%)
RRM 205..>394 CDD:223796 84/287 (29%)
RRM_SAFB_like 313..386 CDD:240863 48/72 (67%)
SWIRM-assoc_1 <588..618 CDD:293104 15/35 (43%)
SafbNP_001361548.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..35 2/9 (22%)
SAP 31..65 CDD:128789 18/33 (55%)
PLN03124 32..>183 CDD:215591 46/158 (29%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 64..117 14/57 (25%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 222..429 31/206 (15%)
RRM 368..>527 CDD:223796 63/158 (40%)
RRM_SAFB1_SAFB2 427..502 CDD:241123 49/74 (66%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 499..661 50/197 (25%)
Interaction with POLR2A, SFRS1, SFRS9 and SFRS10. /evidence=ECO:0000250|UniProtKB:O88453 550..814 89/324 (27%)
Nuclear localization signal. /evidence=ECO:0000255 621..638 5/16 (31%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 684..738 19/53 (36%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C167833984
Domainoid 1 1.000 114 1.000 Domainoid score I6053
eggNOG 1 0.900 - - E1_KOG4661
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 297 1.000 Inparanoid score I2702
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG46608
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0005622
OrthoInspector 1 1.000 - - otm43219
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - LDO PTHR15683
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R1765
SonicParanoid 1 1.000 - - X1802
SwiftOrtho 1 1.000 - -
TreeFam 1 0.960 - -
1312.890

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