Protein Alignment Saf-B and Safb2

DIOPT Version :10

• Sequence 1: NP_733041.2
• Gene: Saf-B / 42958
• FlyBaseID: FBgn0039229
• Length: 928
• Species: Drosophila melanogaster
• Sequence 2: XP_006524220.1
• Gene: Safb2 / 224902
• MGIID: 2146808
• Length: 1017
• Species: Mus musculus
• Alignment Length: 988
• Identity: 285/988 - (28%)
• Similarity: 411/988 - (41%)
• Gaps: 270/988 - (27%)

  Fly     3 EAG-KKIAELRVCDLKSELEKRELETVGPKAVLIERLEKSLRAEGLDPATHLIVPGAKAKKPFAM 66
            |:| :::::|||.||::||:||.|:|.|.|:||:|||.|:.:.||.:|....|..||.:|:....
Mouse    91 ESGTRRLSDLRVIDLRAELKKRNLDTGGNKSVLMERLRKAFKEEGQEPEEVGISWGAVSKRAVKR 155

  Fly    67 PMKDLQSEVVIKEEPIDAN--EEEVKVEQ---------QD---------DYQNGNDYS------- 104
            ..|..:.|    ||..:.|  ||:.:..|         ||         |.....|.|
Mouse   156 NTKGSKME----EEGSEDNGLEEDSRYGQDGVVILQSSQDRDTMDTGVPDGMEAEDLSVPCLGKA 216

  Fly   105 ------HHADDDG-----------------HEIDQ-------VGDVDDECVILDDDD---EEDED 136
                  .||.||.                 |.:|:       ...|.|..|.|.|::   |.:.:
Mouse   217 DTVNQILHAFDDSKEYVAAQLGQLPAQLLKHAVDEEVFKNTLEASVSDLKVTLADEEAPMEPENE 281

  Fly   137 HVYD-------DEPQSGDGDAEGKAQDDGAENNGDDKAIIHGEE--ENTGDTGNMDNDESINLTI 192
            .:.|       .||...:|....:.......:.|.|:.:...|:  |:.|.....:.:|
Mouse   282 KILDILGETCKSEPVKEEGSELEQPFAQATSSVGPDRKLAEEEDLFESCGHPEEEEEEE------ 340

  Fly   193 GEDEQKLLHDEASD---DKSIKSVKPANKSEKSNS---------KDADKKNDDGARSKKRDEKSG 245
             |::|:...:|..|   ..|.||..|:.:.:.|.:         :.||.....|....:|..|..
Mouse   341 -EEDQEEEQEEEGDLALASSSKSESPSTRCQWSEADAPLAVVKRELADAPGGGGGTRHRRKRKRR 404

  Fly   246 DK-----------------------KDSSEQKS---------------------SGKSSNQKDDK 266
            .|                       ::..||.|                     |.:..:.|:|.
Mouse   405 RKHQAQAEALGTGGGAGMNCEPVGLEEPVEQSSTAAQLPEATSQELVRAPTAALSPEPQDSKEDV 469

  Fly   267 EK-----STAAPGGATSSTASSAAGSKSGSGSSAGNGTGANSNNK-QATLS--RNLWVSGLSTLT 323
            :|     ....|.....|:||..|..|..|.....:......:.| :|:.|  |||||||||:.|
Mouse   470 KKFAFDACNDVPAPPKESSASEGADQKMSSVKEEQDIKPVIKDEKGRASCSSGRNLWVSGLSSST 534

  Fly   324 RASDLKAIFSKFGKVIGAKVVTNTRTPGTRCYGYVTMSSSADASRCIENLHRTELHGRIISVERT 388
            ||:|||::|||.|||||||||||.|:||.||||:||||:|.:|::||.:|||||||||:||||:.
Mouse   535 RAADLKSLFSKHGKVIGAKVVTNARSPGARCYGFVTMSTSDEATKCISHLHRTELHGRMISVEKA 599

  Fly   389 KNEIGGSLNSK----EGKGKAPG-DAGNK----------KKEDDSGKKSGSGKGSSSNSGDDKKG 438
            |||.....:|.    :.|.|.|| |..:.          |||:...:|...|      ..|.||.
Mouse   600 KNEPSEKKSSDRRACDQKEKVPGPDRPHPVKIKTEKTVIKKEEKLERKEEKG------PEDIKKE 658

  Fly   439 GDGNGDSKSVGGDLKRDGKESNRARSR---RNDDRGKSLASQDRPRHDRERSAKGSQDHRS-GRN 499
            .|.:..:....|. .|..|..:|...|   .:..:|:.:.|.......::|.:..|||.:| ||.
Mouse   659 KDQDELTPGAAGH-SRVTKSGSRGMERTVVMDKSKGEPVISVKATSRSKDRQSSKSQDRKSEGRE 722

  Fly   500 PRDVDREIQQRQRERERRQREMLSYQKIREERERQRLRERERELREEERRR-REARER------- 556
            .||:                  ||:.||:|:|||:|.|:||||:||.|||| ||.|||
Mouse   723 KRDI------------------LSFDKIKEQRERERQRQREREIRETERRREREQREREQRLDAF 769

  Fly   557 -QRIEEERLQEERRKLAVERERLEREKAELLRMERERQKLERE------KIELERLELKRQQMKI 614
             :|.|:.|||.||.:|..:|:|||||:.|..|:||||.::|||      :|..||.||:|||.::
Mouse   770 QERREKARLQRERMQLQCQRQRLERERLERERLERERMRVERERRKEQQRIMREREELRRQQEQL 834

  Fly   615 --------------MESRDDPGKRGVSKRA--DDRYGDVTDRKRTAIFDAPPPPRFDTNLVSSRS 663
                          :::|.|.|.....|||  :|||.|.              ||.|...
Mouse   835 RAEQERRALRRPYDLDARRDDGYWPEGKRAALEDRYRDF--------------PRPDHRF----- 880

  Fly   664 TYDKKHDDYG---------SSSSTKRV--------LDDYSSSSKRL-----DYSSKRNDYSSSSG 706
             :|..|.|.|         ...|..||        .||..|..:.|     |.....:.|||...
Mouse   881 -HDFDHRDRGHYQEHVIDRRDGSRTRVEERDGQYYPDDQHSHGRLLEHHAWDSGDGWHGYSSDKK 944

  Fly   707 SKRGAVDDYTAVPTKRSNDYSASSSSKRDDYKRDEVRHLPLSGTVGGGSSSSYLHKNNTAGGGAG 771
            ...|   .....|.:.|.:::..||...:  ::..|.|..:...:.|.....:........||.|
Mouse   945 LNEG---QGLPPPPRVSREWAEHSSQLEE--QQVPVWHSAVDTNMTGHEHIRWRGAERGLAGGPG 1004

  Fly   772 SYVHKNNTSGTGG 784
               |.:..:|.||
Mouse  1005 ---HGHVAAGRGG 1014

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Saf-B	NP_733041.2	SAP	11..42	CDD:460424	19/30 (63%)
		2A1904	<16..>270	CDD:273344	79/383 (21%)
		RRM_SF	311..386	CDD:473069	56/76 (74%)
		SWIRM-assoc_1	<588..618	CDD:465142	15/49 (31%)
Safb2	XP_006524220.1	SAP	97..131	CDD:460424	19/33 (58%)
		RRM_SAFB1_SAFB2	522..597	CDD:410080	55/74 (74%)