DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5808 and PPIL4

DIOPT Version :9

Sequence 1:	NP_651291.1	Gene:	CG5808 / 42957	FlyBaseID:	FBgn0027617	Length:	653	Species:	Drosophila melanogaster
Sequence 2:	NP_624311.1	Gene:	PPIL4 / 85313	HGNCID:	15702	Length:	492	Species:	Homo sapiens

Alignment Length:	519	Identity:	256/519 - (49%)
Similarity:	343/519 - (66%)	Gaps:	33/519 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSVVIETTMGDLTVDLFISERPIACLNFLKLCRLKYYNFNLFHTVQQGFIAQTGDPSGAGDGGSS 65
            |:|::|||:||:.:||:..|||.|||||||||::||||:.|.|.||:.||.|||||:|.|.||.|
Human     1 MAVLLETTLGDVVIDLYTEERPRACLNFLKLCKIKYYNYCLIHNVQRDFIIQTGDPTGTGRGGES 65

  Fly    66 IWGVVEGPQKRFFEAEFLPKINHSSAGMLSLVSAGKNLVGSQFFLTLGENLTSLDGNHCVIGEVV 130
            |:|.:.|.|..|||||.:|:|.|...|.:|:|:.|.:..||||.:|.||||..|||.|.|.|||.
Human    66 IFGQLYGDQASFFEAEKVPRIKHKKKGTVSMVNNGSDQHGSQFLITTGENLDYLDGVHTVFGEVT 130

  Fly   131 EGHEVLRKLNDAIVDDSFRPYQDIRITHTVVLEDPFPNPRGLQAPSRSPSPSAERLKNGRIAADE 195
            ||.::::|:|:..||..|.|||||||.|||:|:|||.:|..|..|.|||.|:.|:|.:|||.|||
Human   131 EGMDIIKKINETFVDKDFVPYQDIRINHTVILDDPFDDPPDLLIPDRSPEPTREQLDSGRIGADE 195

  Fly   196 DIDDTDGMTAEEMQEMLAEREAKARATILEIVGDLPDADMAPPENVLFVCKLNPVTTDDDLEIIF 260
            :|||..|.:|||::|:.||:|||.:|.:||:||||||||:.|||||||||||||||||:||||||
Human   196 EIDDFKGRSAEEVEEIKAEKEAKTQAILLEMVGDLPDADIKPPENVLFVCKLNPVTTDEDLEIIF 260

  Fly   261 SSFGVLKGCEVIRDRKTGDSLQYAFVEFEDQKSCEAAYFKMDNVLIDDRRIHVDFSQSVSKVTWR 325
            |.||.::.||||||.|||:||.|||:|||.::.||.|:|||||||||||||||||||||:||.|:
Human   261 SRFGPIRSCEVIRDWKTGESLCYAFIEFEKEEDCEKAFFKMDNVLIDDRRIHVDFSQSVAKVKWK 325

  Fly   326 GKGRGIEGDYRKLDFNNLRDDKDHRKPNNGRSRTEDHKERNRTEDFRNRMSSAERRKAREQRHQE 390
            |||    |.|.|.||.....::|  ||.|...:.:...:    :|.:..:...|:.:..:..|..
Human   326 GKG----GKYTKSDFKEYEKEQD--KPPNLVLKDKVKPK----QDTKYDLILDEQAEDSKSSHSH 380

  Fly   391 QSERDVRKNLQRRTRSKEKDEKSVYRSKKSQNESVRE----NSNRERNRNEKRSSRSRDATHRRY 451
            .|::..:|.   ...|:||:::.....|.:..:..||    :...|.:..||:.|..||.|..|
Human   381 TSKKHKKKT---HHCSEEKEDEDYMPIKNTNQDIYREMGFGHYEEEESCWEKQKSEKRDRTQNR- 441

  Fly   452 SRSRDREERRPSRPRDQLGRRSRSRDQKERRRSRPREQNERRRSRSRDQTGKRPTQNRDRNDSR 515
            ||||.||       ||  |..|.|...|.:     .:..||.||:.||:: :.|.:::|:..|:
Human   442 SRSRSRE-------RD--GHYSNSHKSKYQ-----TDLYERERSKKRDRS-RSPKKSKDKEKSK 490

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5808	NP_651291.1	cyclophilin_RRM	4..169	CDD:238902	93/164 (57%)
		RRM	<237..445	CDD:223796	97/211 (46%)
		RRM_PPIL4	237..319	CDD:240681	65/81 (80%)
PPIL4	NP_624311.1	cyclophilin_RRM	4..161	CDD:238902	88/156 (56%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	167..188		9/20 (45%)
		RRM_PPIL4	237..319	CDD:240681	65/81 (80%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	368..406		7/40 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	423..492		29/84 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165156296
Domainoid	1	1.000	193	1.000	Domainoid score	I3204
eggNOG	1	0.900	-	-		E1_COG0652
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H12126
Inparanoid	1	1.050	470	1.000	Inparanoid score	I1529
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1436035at2759
OrthoFinder	1	1.000	-	-		FOG0005630
OrthoInspector	1	1.000	-	-		oto89592
orthoMCL	1	0.900	-	-		OOG6_102469
Panther	1	1.100	-	-	LDO	PTHR45843
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R965
SonicParanoid	1	1.000	-	-		X4034
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.790