DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5808 and Ppig

DIOPT Version :9

Sequence 1:	NP_651291.1	Gene:	CG5808 / 42957	FlyBaseID:	FBgn0027617	Length:	653	Species:	Drosophila melanogaster
Sequence 2:	NP_113981.2	Gene:	Ppig / 83624	RGDID:	620315	Length:	752	Species:	Rattus norvegicus

Alignment Length:	778	Identity:	193/778 - (24%)
Similarity:	324/778 - (41%)	Gaps:	201/778 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 GDLTVDLFISERPIACLNFLKLC-----------RLKYYNFNLFHTVQQGFIAQTGDPS-GAGDG 62
            |.:..:||....|..|.||..||           :..:|...|||.|.:.|:.|.||.| |.|.|
  Rat    22 GRVVFELFSDVCPKTCENFRCLCTGEKGTGKSTQKPLHYKSCLFHRVVKDFMVQGGDFSEGNGRG 86

  Fly    63 GSSIWGVVEGPQKRFFEAEFLPKINHSSAGMLSLVSAGKNLVGSQFFLTLGENLTSLDGNHCVIG 127
            |.||:|       .|||.|.. .:.|:...:||:.:.||:..|||||:|. :....|||:|.|.|
  Rat    87 GESIYG-------GFFEDESF-AVKHNKEFLLSMANRGKDTNGSQFFITT-KPTPHLDGHHVVFG 142

  Fly   128 EVVEGHEVLRKLNDAIVDDSFRPYQDIRITH--TVVLEDPFPNPRGLQAPSRSPSPSAERLKNGR 190
            :|:.|.||:|::.:...|.:.:|:.::||..  .:|.:.........:..|.|.|.|::...:..
  Rat   143 QVISGQEVVREIENQKTDAASKPFAEVRILSCGELVPKSKVKKEEKKRHKSSSSSSSSDSDSSSD 207

  Fly   191 IAADEDIDDTDGMTAE------------------EMQEMLAEREAKARATILEIVGDLPDADMAP 237
            ..:..|..|::..:.|                  |.::....:::.:..:..:.|...|.:.:.|
  Rat   208 SQSSSDSSDSESASEEKSRKRKKKHRKNSRKHKKEKKKRKKSKKSPSSESEADNVDAQPQSTVRP 272

  Fly   238 ------PENVLFVCKLNPVTTDDDLEIIFSSFGVLKGCEVIRDRKTGDSLQYAFVEFEDQKSCE- 295
                  ||| .|:.:.:|...||                  ::||..        |.|.::.|.
  Rat   273 EEIPPIPEN-RFLMRKSPPKADD------------------KERKNR--------ERERERECNP 310

  Fly   296 -----AAYFKMDNVLIDDRRI----------------HVDFSQSVSKVTWRGK------------ 327
                 |:|.:...|....|:|                ...|.:|.:...||.:
  Rat   311 PNSQPASYQRRFLVTRSGRKIKGRGPRRYRTPSRSRSRDRFRRSETPPHWRQEMQRAQRMRVSSG 375

  Fly   328 GRGIEGDYRKLDFNNLRDDK------------DHR----KPN---NGRSRTEDHKERNRTEDFR- 372
            .|.|:||  |.:.|.:::::            |||    .||   ....:.:|||..::..|.|
  Rat   376 ERWIKGD--KSELNEIKENQRSPVRVKEKKITDHRHMSESPNRKIEKEKKVKDHKSESKERDIRR 438

  Fly   373 --------------------NRMSSAERRKAREQ--RHQEQSERDVRKNLQRRTRSKEKDEKSVY 415
                                :|..|.||.|::|:  :|....::.|      |:||||:|.::.
  Rat   439 NSEKDDKYNKNKVKKRGKSKSRSKSKERSKSKERDSKHSRHEDKRV------RSRSKERDHETT- 496

  Fly   416 RSKKSQNESVRENSNRERNRNEKRSSRSRDATHRRYSRSRDREERRPSRPRDQ-LGRRSRSRDQK 479
            :.|:.|.:|..::..|.|::...:...|:...| .:|:|::::.|..||.|:: |.:...|.:.:
  Rat   497 KEKEKQLDSKGKDQERSRSKENSKQVESKSNEH-DHSKSKEKDRRAQSRSRERDLTKSKHSYNSR 560

  Fly   480 ERRRSRPREQNERRRSRSRDQTGKRPTQNRDRNDSRRFHSPQEGRRNDERSHRETSRNQRRSPER 544
            .|.|||.|:::.|.||||.|         |||:.|:.:|.    .|..|...|..||::.|....
  Rat   561 TRERSRSRDRSRRVRSRSHD---------RDRSRSKEYHR----YREQEYRRRGRSRSRDRRTPG 612

  Fly   545 RQQSRNREDHRMDTHSSPNKSHEKKRKLSVEKSKKQAKKS----------KRAASSSSD--SSES 597
            |.:|::|...|.|:.||..:..:.:.|   ||.:.|..||          ||..|.|.|  ||.:
  Rat   613 RSRSKDRRRRRRDSRSSEREESQSRNK---EKYRSQDSKSSHRKENSEGEKRMYSKSRDHSSSNN 674

  Fly   598 SSESESD------STSSDSSEDS---SSSSSSSDDRSKRKKSTKSKQKKSKSKSSH---KSKK 648
            :.|.::|      |.:..||:|:   ||:..:.:|...|....|..||....::.|   |:||
  Rat   675 NREKKADIDQSPVSKTKQSSQDNEVKSSTLKNQEDEKTRSPVEKENQKSKGQENDHVHDKNKK 737

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5808	NP_651291.1	cyclophilin_RRM	4..169	CDD:238902	57/172 (33%)
		RRM	<237..445	CDD:223796	58/289 (20%)
		RRM_PPIL4	237..319	CDD:240681	19/109 (17%)
Ppig	NP_113981.2	cyclophilin	8..175	CDD:412213	56/161 (35%)
Ppig	NP_113981.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	182..752		136/609 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0652
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810