DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5808 and Ppil4

DIOPT Version :9

Sequence 1:	NP_651291.1	Gene:	CG5808 / 42957	FlyBaseID:	FBgn0027617	Length:	653	Species:	Drosophila melanogaster
Sequence 2:	NP_080417.2	Gene:	Ppil4 / 67418	MGIID:	1914668	Length:	492	Species:	Mus musculus

Alignment Length:	543	Identity:	263/543 - (48%)
Similarity:	346/543 - (63%)	Gaps:	62/543 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSVVIETTMGDLTVDLFISERPIACLNFLKLCRLKYYNFNLFHTVQQGFIAQTGDPSGAGDGGSS 65
            |:|::|||:||:.:||:..|||.|||||||||::||||:.|.|.||:.||.|||||:|.|.||.|
Mouse     1 MAVLLETTLGDVVIDLYTEERPRACLNFLKLCKIKYYNYCLIHNVQRDFIIQTGDPTGTGRGGES 65

  Fly    66 IWGVVEGPQKRFFEAEFLPKINHSSAGMLSLVSAGKNLVGSQFFLTLGENLTSLDGNHCVIGEVV 130
            |:|.:.|.|..|||||.:|:|.|...|.:|:|:.|.:..||||.:|.||||..|||.|.|.|||.
Mouse    66 IFGQLYGDQASFFEAEKVPRIKHKKKGTVSMVNNGSDQHGSQFLITTGENLDYLDGVHTVFGEVT 130

  Fly   131 EGHEVLRKLNDAIVDDSFRPYQDIRITHTVVLEDPFPNPRGLQAPSRSPSPSAERLKNGRIAADE 195
            ||.::::|:|:..||..|.|||||||.|||:|:|||.:|..|..|.|||.|:.|:|.:|||.|||
Mouse   131 EGMDIVKKINETFVDKDFVPYQDIRINHTVILDDPFDDPPDLLIPDRSPEPTKEQLDSGRIGADE 195

  Fly   196 DIDDTDGMTAEEMQEMLAEREAKARATILEIVGDLPDADMAPPENVLFVCKLNPVTTDDDLEIIF 260
            :|||..|.:|||::|:.||:|||.:|.:||:||||||||:.|||||||||||||||||:||||||
Mouse   196 EIDDFKGRSAEEVEEIKAEKEAKTQAILLEMVGDLPDADIKPPENVLFVCKLNPVTTDEDLEIIF 260

  Fly   261 SSFGVLKGCEVIRDRKTGDSLQYAFVEFEDQKSCEAAYFKMDNVLIDDRRIHVDFSQSVSKVTWR 325
            |.||.::.||||||.|||:||.|||:|||.::.||.|:|||||||||||||||||||||:||.|:
Mouse   261 SRFGPIRSCEVIRDWKTGESLCYAFIEFEKEEDCEKAFFKMDNVLIDDRRIHVDFSQSVAKVKWK 325

  Fly   326 GKGRGIEGDYRKLDFNNLRDDKDHRKPNNGRSRTEDHKERNR-TEDFRNRMSSAERRKAREQRHQ 389
            |||    |.|.|.||.....::|  ||.|     ...||:.: .:|.:..:...|:.:..:..|.
Mouse   326 GKG----GKYTKSDFKEYEKEQD--KPAN-----LVLKEKVKPKQDAKYDLILDEQGEDSKSSHS 379

  Fly   390 EQSERDVRKNLQRRTRSKEKDEKSVYRSKKSQNESV----------RENSNRERNRNEKRSSRSR 444
            ..|::..:|.   |..|:||:::. |...|:.|:.:          .|.|..|:.:||||.
Mouse   380 HTSKKHKKKT---RHCSEEKEDEE-YMPIKNPNQDIYREMGFGHYEEEESCWEKQKNEKRD---- 436

  Fly   445 DATHRRYSRSRDREERRPSRPRDQLGRRSRSRDQKERRRSRPREQNERRRSRSRDQTGKRPTQNR 509
                ||.:|||.|     ||.||  |..|.|...|.:     .|..||.|||.||
Mouse   437 ----RRQNRSRSR-----SRERD--GHYSNSHKPKYQ-----TEPYERERSRKRD---------- 475

  Fly   510 DRNDSRRFHSPQEGRRNDERSHR 532
                  |..||::.:..::..:|
Mouse   476 ------RSRSPKKSKAKEKSKYR 492

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5808	NP_651291.1	cyclophilin_RRM	4..169	CDD:238902	93/164 (57%)
		RRM	<237..445	CDD:223796	103/218 (47%)
		RRM_PPIL4	237..319	CDD:240681	65/81 (80%)
Ppil4	NP_080417.2	cyclophilin_RRM	4..161	CDD:238902	88/156 (56%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	167..188		9/20 (45%)
		RRM	<193..>320	CDD:223796	93/126 (74%)
		RRM_PPIL4	237..319	CDD:240681	65/81 (80%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	368..409		10/44 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	423..492		32/104 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167846702
Domainoid	1	1.000	193	1.000	Domainoid score	I3187
eggNOG	1	0.900	-	-		E1_COG0652
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H12126
Inparanoid	1	1.050	473	1.000	Inparanoid score	I1487
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0005630
OrthoInspector	1	1.000	-	-		oto93161
orthoMCL	1	0.900	-	-		OOG6_102469
Panther	1	1.100	-	-	LDO	PTHR45843
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R965
SonicParanoid	1	1.000	-	-		X4034
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	14	13.780