DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5808 and NKTR

DIOPT Version :9

Sequence 1:	NP_651291.1	Gene:	CG5808 / 42957	FlyBaseID:	FBgn0027617	Length:	653	Species:	Drosophila melanogaster
Sequence 2:	NP_001336053.1	Gene:	NKTR / 4820	HGNCID:	7833	Length:	1463	Species:	Homo sapiens

Alignment Length:	862	Identity:	198/862 - (22%)
Similarity:	311/862 - (36%)	Gaps:	252/862 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 MGDLTVDLFISERPIACLNFLKLC-----------RLKYYNFNLFHTVQQGFIAQTGDPS-GAGD 61
            :|.:...||....|..|.|||.||           :...|..:.||.|.:.|:.|.||.| |.|.
Human    20 VGRIMFQLFSDICPKTCKNFLCLCSGEKGLGKTTGKKLCYKGSTFHRVVKNFMIQGGDFSEGNGK 84

  Fly    62 GGSSIWGVVEGPQKRFFEAE-FLPKINHSSAGMLSLVSAGKNLVGSQFFLTLGENLTSLDGNHCV 125
            ||.||:|       .:|:.| |:  :.|..|.:||:.:.||:..|||||:|. :....|||.|.|
Human    85 GGESIYG-------GYFKDENFI--LKHDRAFLLSMANRGKHTNGSQFFITT-KPAPHLDGVHVV 139

  Fly   126 IGEVVEGHEVLRKLNDAIVDDSFRPYQDIRITHTVVL-----EDPFPNPR-------GLQAPSRS 178
            .|.|:.|.||:.::.:...|.:.|||.|:|:....||     :|.|...|       |..:.|.|
Human   140 FGLVISGFEVIEQIENLKTDAASRPYADVRVIDCGVLATKSIKDVFEKKRKKPTHSEGSDSSSNS 204

  Fly   179 PS-----------------------PSAERLKNGR--IAADEDIDDTDGMT-------AEEMQEM 211
            .|                       |..:|.|..|  .::.|:..:...|.       ::..::.
Human   205 SSSSESSSESELEHERSRRRKHKRRPKVKRSKKRRKEASSSEEPRNKHAMNPKGHSERSDTNEKR 269

  Fly   212 LAEREAKARATILEIVGDLPDADMAPPENVLFVCKLNPVTTDD------DLEIIFSSF--GVLKG 268
            ..:..||....::.     |:.....|||...:.:..||.|.:      |:..|.|..  .|.|.
Human   270 SVDSSAKREKPVVR-----PEEIPPVPENRFLLRRDMPVVTAEPEPKIPDVAPIVSDQKPSVSKS 329

  Fly   269 CEVIRDRKTGDSLQY-------AFVEFEDQKSCEA------------AY-------FKMDNVLID 307
            ...|:.|.|   ::|       :..|.:|..|.|.            ||       :...:.|.|
Human   330 GRKIKGRGT---IRYHTPPRSRSCSESDDDDSSETPPHWKEEMQRLRAYRPPSGEKWSKGDKLSD 391

  Fly   308 DRRIHVDFSQSVSKVTWRGKGRGIEGDYRKLD-------FNNLRDDK--DHRKPNNGRSRTEDHK 363
            ......| .:|:|:   |.:.....|.|..|.       ....|.:|  .|:|....:.....||
Human   392 PCSSRWD-ERSLSQ---RSRSWSYNGYYSDLSTARHSGHHKKRRKEKKVKHKKKGKKQKHCRRHK 452

  Fly   364 ERNR-----TEDFRNRMSSAERRKA---RE--------------QRHQEQSERDVRKNLQRRTRS 406
            :..:     ..|..:..||..|.|:   ||              :|...:|::||:.:|...:|.
Human   453 QTKKRRILIPSDIESSKSSTRRMKSSCDRERSSRSSSLSSHHSSKRDWSKSDKDVQSSLTHSSRD 517

  Fly   407 KEKDEKSVYRSKKSQNESVRENSNRERNRNEKRSSRSRDATHRRYSRSRDREERRPSRPRDQLGR 471
            .       ||| ||.::|....|:|.|..: |.||.||..:..|.|......:|....||....:
Human   518 S-------YRS-KSHSQSYSRGSSRSRTAS-KSSSHSRSRSKSRSSSKSGHRKRASKSPRKTASQ 573

  Fly   472 RSRSRDQKERRRSRPREQNER--------------------------------RRSRSRDQTGKR 504
            .|.::..|.........|||.                                :.|..|.|..|.
Human   574 LSENKPVKTEPLRATMAQNENVVVQPVVAENIPVIPLSDSPPPSRWKPGQKPWKPSYERIQEMKA 638

  Fly   505 PTQN-------------RDRNDSRRFHSPQEGRRND------------ERSHRETSRNQR----- 539
            .|.:             ::...|..:|..::...:|            |.|.|..||:.|
Human   639 KTTHLLPIQSTYSLANIKETGSSSSYHKREKNSESDQSTYSKYSDRSSESSPRSRSRSSRSRSYS 703

  Fly   540 ----------------RSPERRQQSRNR-EDH----RMDTHSSPNKSHEKKRKLSVEKSKKQAKK 583
                            |||..|..|||: .||    |..:::|.:....::.|..:..|.|:...
Human   704 RSYTRSRSLASSHSRSRSPSSRSHSRNKYSDHSQCSRSSSYTSISSDDGRRAKRRLRSSGKKNSV 768

  Fly   584 SKRAASSSSDSSESS---------------SESESD-STSSDSSEDSSSSSSSSDDRSKRKKSTK 632
            |.:..||||:.:..|               |||.|. ..||||.:.|..::.|:.::.|:.:..:
Human   769 SHKKHSSSSEKTLHSKYVKGRDRSSCVRKYSESRSSLDYSSDSEQSSVQATQSAQEKEKQGQMER 833

  Fly   633 SKQKKSKSKSSHKSKKK 649
            :..|:.|::...|||.:
Human   834 THNKQEKNRGEEKSKSE 850

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5808	NP_651291.1	cyclophilin_RRM	4..169	CDD:238902	61/177 (34%)
		RRM	<237..445	CDD:223796	62/272 (23%)
		RRM_PPIL4	237..319	CDD:240681	24/115 (21%)
NKTR	NP_001336053.1	cyclophilin	7..174	CDD:320812	57/163 (35%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	187..591		84/424 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	607..627		0/19 (0%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	658..1072		45/193 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1129..1156
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1169..1215
		Arg/Ser tandem repeat-rich	1311..1348
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0652
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810