DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5808 and ppid

DIOPT Version :9

Sequence 1:	NP_651291.1	Gene:	CG5808 / 42957	FlyBaseID:	FBgn0027617	Length:	653	Species:	Drosophila melanogaster
Sequence 2:	NP_001002065.1	Gene:	ppid / 415155	ZFINID:	ZDB-GENE-040625-34	Length:	371	Species:	Danio rerio

Alignment Length:	443	Identity:	90/443 - (20%)
Similarity:	155/443 - (34%)	Gaps:	141/443 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 MGDLTVDLFISERPIACLNFLKLC-----------RLKYYNFNLFHTVQQGFIAQTGDPSGA-GD 61
            :|.:..:||....|....||..||           :..::....||.:.:.|:.|.||.|.. |.
Zfish    29 VGRVVFELFADVVPKTAENFRALCTGEKGVGKSTGKPLHFKGCPFHRIIKSFMIQGGDFSNQNGT 93

  Fly    62 GGSSIWGVVEGPQKRFFEAEFLPKINHSSAGMLSLVSAGKNLVGSQFFLTLGENLTSLDGNHCVI 126
            ||.||:|      .:|.:..|..|  |...|:||:.:||.|..|||||:|.... ..|||.|.|.
Zfish    94 GGESIYG------DKFEDENFHYK--HDREGLLSMANAGPNTNGSQFFITTVPT-PHLDGKHVVF 149

  Fly   127 GEVVEGHEVLRKLNDAIVDDSFRPYQDIRITHTVVLEDPFPNPRGLQAPSRSPSPSAERLKNGRI 191
            |:|::|..|::.|      ::....:|..:...|:.|                        .|..
Zfish   150 GQVLKGMGVVKML------EAMETKEDNPVKPCVIAE------------------------CGEH 184

  Fly   192 AADED----IDDTDGMTAEEMQEMLAEREAKARATILEIVGDLP---DADMAPPENVLFVCKLNP 249
            .|.:|    ::|..|                      :...|.|   :.|....:.||.|.
Zfish   185 KAGDDWSIALNDGSG----------------------DAYPDFPEDSEVDFKDVDKVLSVA---- 223

  Fly   250 VTTDDDLEIIFSSFGVLKGCEVIRDRKTGDSLQYAFVEFEDQKSCEAAYFKMDNVLIDDRRIHVD 314
                :||:.|.::|            ....:.|.|..::    |....|.:|...::||     |
Zfish   224 ----EDLKNIGNNF------------FKAQNWQSAIKKY----SKALRYLEMCGNIVDD-----D 263

  Fly   315 FSQSVSKVT-----------------WRGKGRGIEGDYRKLDFNNLRDDKDHRKPNNGRSRTEDH 362
            .||...:.|                 |:   ..||.....|:.|........|:....:...|.:
Zfish   264 SSQKKLEPTALSCILNTAACKLKLKLWQ---EAIESCDEVLELNQTNTKALFRRAQAWQGLKEFN 325

  Fly   363 KERNRTEDFRNRMSSAERRKAREQRHQEQSERDVRKNLQRRTRSKEKDEKSVY 415
            |            :..:.:||.|...::::..:....::::.:.:::.||.:|
Zfish   326 K------------AMVDLKKAHEIAPEDKAIGNEMNKVKQQVKEEKEKEKKIY 366

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5808	NP_651291.1	cyclophilin_RRM	4..169	CDD:238902	50/171 (29%)
		RRM	<237..445	CDD:223796	32/196 (16%)
		RRM_PPIL4	237..319	CDD:240681	17/81 (21%)
ppid	NP_001002065.1	cyclophilin_ABH_like	16..182	CDD:238907	50/191 (26%)
		TPR_11	223..304	CDD:290150	19/112 (17%)
		TPR repeat	223..268	CDD:276809	14/73 (19%)
		TPR_12	271..340	CDD:290160	12/83 (14%)
		TPR repeat	273..303	CDD:276809	4/32 (13%)
		TPR repeat	308..336	CDD:276809	5/39 (13%)
		TPR_1	309..341	CDD:278916	6/43 (14%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0652
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.900