DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5808 and RBMY1B

DIOPT Version :9

Sequence 1:	NP_651291.1	Gene:	CG5808 / 42957	FlyBaseID:	FBgn0027617	Length:	653	Species:	Drosophila melanogaster
Sequence 2:	NP_001006121.1	Gene:	RBMY1B / 378948	HGNCID:	23914	Length:	496	Species:	Homo sapiens

Alignment Length:	494	Identity:	111/494 - (22%)
Similarity:	160/494 - (32%)	Gaps:	140/494 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   242 LFVCKLNPVTTDDDLEIIFSSFGVLKGCEVIRDRKTGDSLQYAFVEFEDQKSCEAAYFKMDNVLI 306
            ||:..||..|.:..|:.:|...|.:....:|:|| |..|..:||:.||:....:.|...|:...:
Human    10 LFIGGLNRETNEKMLKAVFGKHGPISEVLLIKDR-TSKSRGFAFITFENPADAKNAAKDMNGKSL 73

  Fly   307 DDRRIHVDFSQSVSKVTWRGKGRGIEGDYRKLDFNNLRDDKDHRKPNNGRSRTEDHKERNRTEDF 371
            ..:.|.|   :...|.:::..||                    |:|               ....
Human    74 HGKAIKV---EQAKKPSFQSGGR--------------------RRP---------------PASS 100

  Fly   372 RNRMSSAERRKAREQR------------HQEQS--ERDVRKNLQRRTRSKEKDEKSVYRS----- 417
            |||..|...|.||..|            |.:..  ..|::.:..|.....::...|  ||
Human   101 RNRSPSGSLRSARGSRGGTRGWLPSQEGHLDDGGYTPDLKMSYSRGLIPVKRGPSS--RSGGPPP 163

  Fly   418 KKSQNESV-REN---------SNRERN-------------RNEKRSSR-----SRDATHRRYSRS 454
            |||...:| |.|         |.|..|             ||::.|:|     :.|..|.....:
Human   164 KKSAPSAVARSNSWMGSQGPMSQRRENYGVPPRRATISSWRNDRMSTRHDGYATNDGNHPSCQET 228

  Fly   455 RDREERRPSRPRDQLGRRSRSRDQKERRRSRPREQNERRRSRSRDQT-GKRPTQNRDRNDSRRFH 518
            ||...  |||..........:||:...|..|    |.|....:||.. ..|....||...|||..
Human   229 RDYAP--PSRGYAYRDNGHSNRDEHSSRGYR----NHRSSRETRDYAPPSRGHAYRDYGHSRRDE 287

  Fly   519 SPQEGRRNDERSHRET------------------------SRNQRRSPERRQQSRNREDHR---- 555
            |...|.|| .||.|||                        ||..|..|..|:.......||
Human   288 SYSRGYRN-RRSSRETREYAPPSRGHGYRDYGHSRRHESYSRGYRNHPSSRETRDYAPPHRDYAY 351

  Fly   556 -------MDTHSSPNKSHEK--KRKLSVEKSKKQAKKSKRAASSSSDSSESSSESESDSTSSDSS 611
                   .|.|||...|:..  ...|..:.|:..:..|.|.|.....:|..:..:.....|...|
Human   352 RDYGHSSWDEHSSRGYSYHDGYGEALGRDHSEHLSGSSYRDALQRYGTSHGAPPARGPRMSYGGS 416

  Fly   612 EDSSSSSSSSDDRSKRKKSTKSKQKKSKSKSSHKSKKKH 650
              :..:.|::.||..|     |.:..|.....|...::|
Human   417 --TCHAYSNTRDRYGR-----SWESYSSCGDFHYCDREH 448

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5808	NP_651291.1	cyclophilin_RRM	4..169	CDD:238902
		RRM	<237..445	CDD:223796	53/249 (21%)
		RRM_PPIL4	237..319	CDD:240681	21/76 (28%)
RBMY1B	NP_001006121.1	RRM	<1..189	CDD:223796	48/219 (22%)
		RRM_RBMX_like	7..85	CDD:240828	21/78 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	67..349		72/328 (22%)
		RBM1CTR	174..218	CDD:285341	8/43 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	452..496
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910