DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5808 and Ppid

DIOPT Version :9

Sequence 1:	NP_651291.1	Gene:	CG5808 / 42957	FlyBaseID:	FBgn0027617	Length:	653	Species:	Drosophila melanogaster
Sequence 2:	NP_001004279.1	Gene:	Ppid / 361967	RGDID:	1303174	Length:	370	Species:	Rattus norvegicus

Alignment Length:	271	Identity:	70/271 - (25%)
Similarity:	112/271 - (41%)	Gaps:	52/271 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 MGDLTVDLFISERPIACLNFLKLC-----------RLKYYNFNLFHTVQQGFIAQTGDPSGA-GD 61
            :|.:.::||....|....||..||           :..::....||.:.:.|:.|.||.|.. |.
  Rat    29 VGRIVLELFADIVPKTAENFRALCTGEKGTGPTTGKPLHFKGCPFHRIIKKFMIQGGDFSNQNGT 93

  Fly    62 GGSSIWGVVEGPQKRFFEAEFLPKINHSSAGMLSLVSAGKNLVGSQFFLTLGENLTSLDGNHCVI 126
            ||.||:|      ::|.:..|..|  |...|:||:.:||.|..|||||:|.... ..|||.|.|.
  Rat    94 GGESIYG------EKFEDENFHYK--HDREGLLSMANAGPNTNGSQFFITTVPT-PHLDGKHVVF 149

  Fly   127 GEVVEGHEVLRKLNDAIVDDSFRPYQDIRITHTVVLEDP-----FPNPRGLQAPSRSPSPSAERL 186
            |:|::|..|.|.|.:..|:.. :|.:...|.....|::.     ||......:....|..
  Rat   150 GQVIKGLGVARMLENVEVNGE-KPAKLCVIAECGELKEGDEWGIFPKDGSGDSHPDFPED----- 208

  Fly   187 KNGRIAADEDIDDTDG--MTAEEMQ------------EMLAEREAKARATILEIVGDLPDADMAP 237
                  ||.|:.|.|.  :.:|:::            ||..::.||....:......:..||::.
  Rat   209 ------ADIDLKDVDKILLISEDLKNIGNTFFKSQNWEMAIKKYAKVLRYLDSSKAVIEKADVSR 267

  Fly   238 PENVLFVCKLN 248
            .:.:...|.||
  Rat   268 LQPIALSCVLN 278

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5808	NP_651291.1	cyclophilin_RRM	4..169	CDD:238902	54/176 (31%)
		RRM	<237..445	CDD:223796	3/12 (25%)
		RRM_PPIL4	237..319	CDD:240681	3/12 (25%)
Ppid	NP_001004279.1	cyclophilin_ABH_like	16..182	CDD:238907	51/162 (31%)
		Chaperone activity. /evidence=ECO:0000250	185..215		6/40 (15%)
		3a0801s09	192..>330	CDD:273380	18/98 (18%)
		Interaction with HSP90AB1. /evidence=ECO:0000250	214..370		12/65 (18%)
		TPR repeat	223..251	CDD:276809	5/27 (19%)
		TPR repeat	272..302	CDD:276809	3/7 (43%)
		TPR repeat	307..335	CDD:276809
		TPR repeat	341..364	CDD:276809
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0652
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.900