DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5808 and Ppil4

DIOPT Version :9

Sequence 1:	NP_651291.1	Gene:	CG5808 / 42957	FlyBaseID:	FBgn0027617	Length:	653	Species:	Drosophila melanogaster
Sequence 2:	NP_001381983.1	Gene:	Ppil4 / 361449	RGDID:	1311051	Length:	492	Species:	Rattus norvegicus

Alignment Length:	529	Identity:	259/529 - (48%)
Similarity:	345/529 - (65%)	Gaps:	53/529 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSVVIETTMGDLTVDLFISERPIACLNFLKLCRLKYYNFNLFHTVQQGFIAQTGDPSGAGDGGSS 65
            |:|::|||:||:.:||:..|||.|||||||||::||||:.|.|.||:.||.|||||:|.|.||.|
  Rat     1 MAVLLETTLGDVVIDLYTEERPRACLNFLKLCKIKYYNYCLIHNVQRDFIIQTGDPTGTGRGGES 65

  Fly    66 IWGVVEGPQKRFFEAEFLPKINHSSAGMLSLVSAGKNLVGSQFFLTLGENLTSLDGNHCVIGEVV 130
            |:|.:.|.|..|||||.:|:|.|...|.:|:|:.|.:..||||.:|.||||..|||.|.|.|||.
  Rat    66 IFGQLYGDQASFFEAEKVPRIKHKKKGTVSMVNNGSDQHGSQFLITTGENLDYLDGVHTVFGEVT 130

  Fly   131 EGHEVLRKLNDAIVDDSFRPYQDIRITHTVVLEDPFPNPRGLQAPSRSPSPSAERLKNGRIAADE 195
            ||.::::|:|:..||..|.|||||||.|||:|:|||.:|..|..|.|||.|:.|:|.:|||.|||
  Rat   131 EGMDIVKKINETFVDKDFVPYQDIRINHTVILDDPFDDPPDLLIPDRSPEPTKEQLDSGRIGADE 195

  Fly   196 DIDDTDGMTAEEMQEMLAEREAKARATILEIVGDLPDADMAPPENVLFVCKLNPVTTDDDLEIIF 260
            :|||..|.:|||::|:.||:|||.:|.:||:||||||||:.|||||||||||||||||:||||||
  Rat   196 EIDDFKGRSAEEVEEIKAEKEAKTQAILLEMVGDLPDADIKPPENVLFVCKLNPVTTDEDLEIIF 260

  Fly   261 SSFGVLKGCEVIRDRKTGDSLQYAFVEFEDQKSCEAAYFKMDNVLIDDRRIHVDFSQSVSKVTWR 325
            |.||.::.||||||.|||:||.|||:|||.::.||.|:|||||||||||||||||||||:||.|:
  Rat   261 SRFGPIRSCEVIRDWKTGESLCYAFIEFEKEEDCEKAFFKMDNVLIDDRRIHVDFSQSVAKVKWK 325

  Fly   326 GKGRGIEGDYRKLDFNNLRDDKDHRKPNNGRSRTEDHKERNR-TEDFRNRMSSAERRKAREQRHQ 389
            |||    |.|.|.||.....::|  ||.|     ...||:.: .:|.:..:...|:.:..:..|.
  Rat   326 GKG----GKYTKSDFKEYEKEQD--KPAN-----LVLKEKVKPKQDAKYDLILDEQAEDSKSSHS 379

  Fly   390 EQSERDVRKNLQRRTRSKEKDEKSVYRSKKSQNESV----------RENSNRERNRNEKRSSRSR 444
            ..|::..:|.   |..|:||:::. |...|:.|:.:          .|.|..|:.:||||.
  Rat   380 HTSKKHKKKT---RHCSEEKEDED-YMPIKNPNQDIYREMGFGHYEEEESCWEKQKNEKRD---- 436

  Fly   445 DATHRRYSRSRDREERRPSRPRDQLGRRSRSRDQKERRRSRPREQN---ERRRSRSRDQTGKRPT 506
                ||.:|||.               |||.||.......:|:.|.   ||.|||.||:: :.|.
  Rat   437 ----RRQNRSRS---------------RSRERDGHYSNSHKPKYQTDPYERERSRKRDRS-RSPK 481

  Fly   507 QNRDRNDSR 515
            :::|:..|:
  Rat   482 KSKDKEKSK 490

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5808	NP_651291.1	cyclophilin_RRM	4..169	CDD:238902	93/164 (57%)
		RRM	<237..445	CDD:223796	103/218 (47%)
		RRM_PPIL4	237..319	CDD:240681	65/81 (80%)
Ppil4	NP_001381983.1	cyclophilin_RRM	4..161	CDD:238902	88/156 (56%)
Ppil4	NP_001381983.1	RRM_PPIL4	237..319	CDD:409681	65/81 (80%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166350231
Domainoid	1	1.000	193	1.000	Domainoid score	I3108
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H12126
Inparanoid	1	1.050	475	1.000	Inparanoid score	I1437
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1436035at2759
OrthoFinder	1	1.000	-	-		FOG0005630
OrthoInspector	1	1.000	-	-		oto96709
orthoMCL	1	0.900	-	-		OOG6_102469
Panther	1	1.100	-	-	LDO	PTHR45843
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X4034
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	13	12.900