DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5808 and rct1

DIOPT Version :9

Sequence 1:	NP_651291.1	Gene:	CG5808 / 42957	FlyBaseID:	FBgn0027617	Length:	653	Species:	Drosophila melanogaster
Sequence 2:	NP_595894.1	Gene:	rct1 / 2539942	PomBaseID:	SPBC17G9.05	Length:	432	Species:	Schizosaccharomyces pombe

Alignment Length:	466	Identity:	215/466 - (46%)
Similarity:	295/466 - (63%)	Gaps:	51/466 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSVVIETTMGDLTVDLFISERPIACLNFLKLCRLKYYNFNLFHTVQQGFIAQTGDPSG-AGDGGS 64
            |||:||||:|||.:|||:.|.|..|.||||||:||||||..|:.:|..:..|||||.| .||||.
pombe     1 MSVLIETTVGDLVIDLFVKEAPKTCENFLKLCKLKYYNFCPFYNIQHNYTCQTGDPLGPTGDGGR 65

  Fly    65 SIWGVVEGPQKRFFEAEFLPKINHSSAGMLSLVSA------GKNLV-GSQFFLTLGENLTSLDGN 122
            .:|.|: ....|||:|||.|.:.|:..|::|:.:|      .|.|| ||||.:||.:||..||..
pombe    66 CVWNVL-NKGTRFFKAEFNPSLVHNKMGLVSMSTATISSRDDKLLVCGSQFIITLSDNLEGLDER 129

  Fly   123 HCVIGEVVEGHEVLRKLNDAIVDDSFRPYQDIRITHTVVLEDPFPNPRGLQAPSRSPSPSAERLK 187
            :.:.|:|.||.:.|.|:||||.|:..:||:||||.||::|:|||.:|..|..|.|||||:.|:|.
pombe   130 YPIYGQVAEGFDTLLKINDAICDEEGQPYRDIRIKHTIILDDPFEDPPDLVEPLRSPSPTPEQLA 194

  Fly   188 NGRIAADEDIDDTDGMTAEEMQEMLAEREAKARATILEIVGDLPDADMAPPENVLFVCKLNPVTT 252
            ..||..:|.|:..   |:|:..:...|.||:|.|..||::||||.|.:||||||||||||||||.
pombe   195 TVRIGENEQIESE---TSEDKLQREKEMEAEAEAVTLEMIGDLPFAHVAPPENVLFVCKLNPVTQ 256

  Fly   253 DDDLEIIFSSFGVLKGCEVIRDRKTGDSLQYAFVEFEDQKSCEAAYFKMDNVLIDDRRIHVDFSQ 317
            |:|||:|||.||.:..|:||||::|||||||||:||::::|.|.|||||.||||||.||||||||
pombe   257 DEDLELIFSRFGKIISCQVIRDKETGDSLQYAFIEFDNKESVEKAYFKMQNVLIDDSRIHVDFSQ 321

  Fly   318 SVSKVTWRGKGRGIEGDYRKLDFNNLRDDKDHRKPNNGRSRTEDHKERNRTEDFRNRMSS----- 377
            ||::             ||:. :|:.||    ||.::.||   |.:|.:|..|.|...|:
pombe   322 SVAR-------------YRQY-YNSNRD----RKRSSSRS---DDREYHRRSDGRYDRSNYRDDY 365

  Fly   378 AERRKAREQRHQEQSERDVRKNLQRRTRSKEKDEKSVYRSKKSQNES----VRENSNRERNRNEK 438
            ..|||.|:.|..:.|.|:      .|..:...|::|.::.:.:.|::    :|:.|...|.|.::
pombe   366 RHRRKERDHRDDQSSFRN------ERFSNYYGDDRSYHKRRNTGNKNCDDHLRDKSPERRYRYDR 424

  Fly   439 RSSRSRDATHR 449
               |.||..:|
pombe   425 ---RYRDDRYR 432

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5808	NP_651291.1	cyclophilin_RRM	4..169	CDD:238902	86/172 (50%)
		RRM	<237..445	CDD:223796	94/216 (44%)
		RRM_PPIL4	237..319	CDD:240681	61/81 (75%)
rct1	NP_595894.1	cyclophilin_RRM	4..176	CDD:238902	86/172 (50%)
		RRM	151..417	CDD:223796	133/295 (45%)
		RRM_PPIL4	241..323	CDD:240681	61/81 (75%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	160	1.000	Domainoid score	I984
eggNOG	1	0.900	-	-		E1_COG0652
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H12126
Inparanoid	1	1.050	369	1.000	Inparanoid score	I443
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0005630
OrthoInspector	1	1.000	-	-		oto101072
orthoMCL	1	0.900	-	-		OOG6_102469
Panther	1	1.100	-	-	LDO	PTHR45843
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R965
SonicParanoid	1	1.000	-	-		X4034
TreeFam	1	0.960	-	-
	13	12.850