DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5808 and Ppig

DIOPT Version :9

Sequence 1:	NP_651291.1	Gene:	CG5808 / 42957	FlyBaseID:	FBgn0027617	Length:	653	Species:	Drosophila melanogaster
Sequence 2:	NP_001074555.1	Gene:	Ppig / 228005	MGIID:	2445173	Length:	752	Species:	Mus musculus

Alignment Length:	781	Identity:	196/781 - (25%)
Similarity:	315/781 - (40%)	Gaps:	204/781 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 GDLTVDLFISERPIACLNFLKLC-----------RLKYYNFNLFHTVQQGFIAQTGDPS-GAGDG 62
            |.:..:||....|..|.||..||           :..:|...|||.|.:.|:.|.||.| |.|.|
Mouse    22 GRVVFELFSDVCPKTCENFRCLCTGEKGTGKSTQKPLHYKSCLFHRVVKDFMVQGGDFSEGNGRG 86

  Fly    63 GSSIWGVVEGPQKRFFEAEFLPKINHSSAGMLSLVSAGKNLVGSQFFLTLGENLTSLDGNHCVIG 127
            |.||:|       .|||.|.. .:.|:...:||:.:.||:..|||||:|. :....|||:|.|.|
Mouse    87 GESIYG-------GFFEDESF-AVKHNKEFLLSMANRGKDTNGSQFFITT-KPTPHLDGHHVVFG 142

  Fly   128 EVVEGHEVLRKLNDAIVDDSFRPYQDIRITHTVVLEDPFPNPRGLQAP-SRSPSPSAERLKNGRI 191
            :|:.|.||:|::.:...|.:.:|:.::||...           |...| |:......:|.|:...
Mouse   143 QVISGQEVVREIENQKTDAASKPFAEVRILSC-----------GELIPKSKVKKEEKKRHKSSSS 196

  Fly   192 AADEDID-DTDGMTAEEMQEMLAEREAKAR-----------------------------ATILEI 226
            ::..|.| .:|..::.|..:..:..|.|:|                             .:..|.
Mouse   197 SSSSDSDSSSDSQSSSESSDSESASEEKSRKRKKKHRKNSRKHKKEKKKRKKSKKSPSSESEAEN 261

  Fly   227 VGDLPDADMAP------PENVLFVCKLNPVTTDDDLEIIFSSFGVLKGCEVIRDRKTGDSLQYAF 285
            |...|.:.:.|      ||| .|:.:.:|...||                  ::||..
Mouse   262 VDAQPQSTVRPEEIPPIPEN-RFLMRKSPPKADD------------------KERKNR------- 300

  Fly   286 VEFEDQKSCE------AAYFKMDNVLIDDRRI----------------HVDFSQSVSKVTWRGK- 327
             |.|.::.|.      |:|.:...|....|:|                ...|.:|.:...||.:
Mouse   301 -ERERERECNPPNSQPASYQRRFLVTRSGRKIKGRGPRRYRTPSRSRSRDRFRRSETPPHWRQEM 364

  Fly   328 -----------GRGIEGDYRKLDFNNLRDDK------------DHR----KPN---NGRSRTEDH 362
                       .|.|:||  |.:.|.:::::            |||    .||   ....:.:||
Mouse   365 QRAQRMRVSSGERWIKGD--KSELNEIKENQRSPVRVKEKKITDHRHMSESPNRKVEKEKKAKDH 427

  Fly   363 KERNRTEDFR---------------------NRMSSAERRKAREQ--RHQEQSERDVRKNLQRRT 404
            |..::..|.|                     :|..|.||.|::|:  :|....::.||...:.|.
Mouse   428 KSESKERDIRRNSEKDDKYNKNKVKKRGKSKSRSKSKERSKSKERDSKHSRHEDKRVRSRSKERD 492

  Fly   405 R--SKEKDEKSVYRSKKSQNESVRENSNR-ERNRNEKRSSRSRDATHRRYSRSRDRE-------- 458
            .  :|||::....:.|..:....:|||.: |...||...|:|::...|..||||:|:
Mouse   493 HETTKEKEKPLDPKGKDQERSRSKENSKQVESKSNEHDHSKSKEKDRRAQSRSRERDLTKSKHSY 557

  Fly   459 ---ERRPSRPRDQLGR-RSRSRDQKERRRS----RPREQNERRRSRSRDQTGKRPTQNRDRNDSR 515
               .|..||.||:..| ||||.| ::|.||    |.|||..|||.|||.:..:.|.::|.::..|
Mouse   558 NSRTRERSRSRDRSRRVRSRSHD-RDRSRSKEYHRYREQEYRRRGRSRSRDRRTPGRSRSKDRRR 621

  Fly   516 RFHSPQEGRRNDERSHRETSRNQRRSPERRQQSRNREDHRMDTHSSPNKSHEKKRKLSVEKSKKQ 580
            |       ||:...|.||.|:::.:...|.|:|::  .||.:......:::.|.|..: ..|..:
Mouse   622 R-------RRDSRSSEREESQSRNKDKYRSQESKS--SHRKENSEGEKRTYSKSRDHN-SSSNNR 676

  Fly   581 AKKSKRAASSSSDSSESSSESESDSTSSDSSEDSSSSSSSSDDRSKRKKSTKSKQKKSKSKSSHK 645
            .||:.|..|..|.:.:||.::|..|::..:.||..:.|....:..|.|............|..|:
Mouse   677 EKKADREQSPVSKTKQSSQDNEVKSSTLKNQEDEKTRSPVEKENQKSKGQENDHVHDKNKKCDHE 741

  Fly   646 S 646
            |
Mouse   742 S 742

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5808	NP_651291.1	cyclophilin_RRM	4..169	CDD:238902	56/170 (33%)
		RRM	<237..445	CDD:223796	60/292 (21%)
		RRM_PPIL4	237..319	CDD:240681	19/109 (17%)
Ppig	NP_001074555.1	cyclophilin	8..175	CDD:412213	56/172 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	182..752		137/601 (23%)
		PTZ00121	<401..750	CDD:173412	97/353 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0652
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810