DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG5808 and Ranbp2

DIOPT Version :10

Sequence 1:NP_651291.1 Gene:CG5808 / 42957 FlyBaseID:FBgn0027617 Length:653 Species:Drosophila melanogaster
Sequence 2:NP_035370.2 Gene:Ranbp2 / 19386 MGIID:894323 Length:3053 Species:Mus musculus


Alignment Length:135 Identity:47/135 - (34%)
Similarity:70/135 - (51%) Gaps:13/135 - (9%)


- Green bases have known domain annotations that are detailed below.


  Fly     9 MGDLTVDLFISERPIACLNFLKLCR-LKYYNF--NLFHTVQQGFIAQTGD-PSGAGDGGSSIWGV 69
            :|.:.::||.:..|....||..||. .|.:.|  ::||.|...||.|.|| ....|.||.||:| 
Mouse  2906 LGRIIMELFSNIVPQTAENFRALCTGEKGFGFKNSIFHRVVPDFICQGGDITKYNGTGGQSIYG- 2969

  Fly    70 VEGPQKRFFEAEFLPKINHSSAGMLSLVSAGKNLVGSQFFLTLGENLTSLDGNHCVIGEVVEGHE 134
                 .:|.:..|  .:.|:..|:||:.:.|:|...||||:|| :....||..|.|.|.|.:|.:
Mouse  2970 -----DKFDDENF--DLKHTGPGLLSMANYGQNTNSSQFFITL-KKAEHLDFKHVVFGFVKDGMD 3026

  Fly   135 VLRKL 139
            .:||:
Mouse  3027 TVRKI 3031

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG5808NP_651291.1 cyclophilin_RRM 4..169 CDD:238902 47/135 (35%)
RRM_PPIL4 237..319 CDD:409681
PRK12678 344..>510 CDD:237171
U2AF_lg 467..>572 CDD:273727
Ranbp2NP_035370.2 TPR 1 26..59
LapB <33..221 CDD:442196
TPR repeat 59..89 CDD:276809
TPR 2 60..93
TPR 3 94..128
TPR 4 165..201
TPR 5 288..319
TPR 6 583..616
TPR 7 648..681
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 773..802
20 X 2 AA repeats of F-G. /evidence=ECO:0000305 1000..3035 47/135 (35%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1147..1171
RanBD1_RanBP2-like 1180..1296 CDD:270203
zf-RanBP 1345..1374 CDD:395516
RanBP2-type Zn finger 1350..1369 CDD:275375
zf-RanBP 1410..1438 CDD:395516
RanBP2-type Zn finger 1414..1433 CDD:275375
zf-RanBP 1469..1498 CDD:395516
RanBP2-type Zn finger 1473..1492 CDD:275375
zf-RanBP 1499..1524 CDD:395516
RanBP2-type Zn finger 1502..1521 CDD:275375
zf-RanBP 1558..1587 CDD:395516
RanBP2-type Zn finger 1562..1581 CDD:275375
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1587..1609
zf-RanBP 1617..1645 CDD:395516
RanBP2-type Zn finger 1621..1640 CDD:275375
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1648..1675
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1744..1772
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1819..1846
RanBD2_RanBP2-like 1864..1980 CDD:269998
Interaction with BICD2. /evidence=ECO:0000250|UniProtKB:P49792 1984..2124
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2030..2060
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2111..2144
RanBD3_RanBP2-like 2161..2277 CDD:270204
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2316..2348
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2394..2430
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2443..2463
IR1-M 2468..2530 CDD:463488
Interaction with sumoylated RANGAP1. /evidence=ECO:0000250 2468..2472
2 X 50 AA approximate repeats 2470..2596
Required for E3 SUMO-ligase activity. /evidence=ECO:0000250 2470..2545
Interaction with UBE2I. /evidence=ECO:0000250 2470..2522
Interaction with SUMO1. /evidence=ECO:0000250 2523..2596
IR1-M 2544..2604 CDD:463488
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2598..2666
RanBD4_RanBP2-like 2754..2870 CDD:269999
cyclophilin_ABH_like 2893..3051 CDD:238907 47/135 (35%)
Blue background indicates that the domain is not in the aligned region.

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