DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment lili and LMBR1L

DIOPT Version :9

Sequence 1:	NP_651290.1	Gene:	lili / 42956	FlyBaseID:	FBgn0027539	Length:	527	Species:	Drosophila melanogaster
Sequence 2:	XP_024304815.1	Gene:	LMBR1L / 55716	HGNCID:	18268	Length:	521	Species:	Homo sapiens

Alignment Length:	521	Identity:	230/521 - (44%)
Similarity:	310/521 - (59%)	Gaps:	42/521 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 EEEEEEVTDLKLQLFHNTVREHIIFLLLIILLYSSSYVVVSRFRRRDRDDLYSNDEDEVLVYRIS 67
            |..:.||..::.||||..:||.||..||...||...::.::||::  ..:..:.|:::..|.:|:
Human     2 EAPDYEVLSVREQLFHERIRECIISTLLFATLYILCHIFLTRFKK--PAEFTTVDDEDATVNKIA 64

  Fly    68 FWLCTFTLAVAEGAAMLLPVSIASNEVLLLYPNSYYVKWLNSSLIQGLWNHVFLFSNLSLFIFLP 132
            ..|||||||:|.||.:|||.||.||||||..|.:||::|||.|||.||||.|||||||||...:|
Human    65 LELCTFTLAIALGAVLLLPFSIISNEVLLSLPRNYYIQWLNGSLIHGLWNLVFLFSNLSLIFLMP 129

  Fly   133 FVYLFSESTGFVGNKKGILPRVYETFTVFMLMAIIVLVLTAVLSAVF-----GIEKLQFFWFLNL 192
            |.|.|:||.||.|::||:|.|||||..:.||:.::||.:..|.||:.     ..|.|..||
Human   130 FAYFFTESEGFAGSRKGVLGRVYETVVMLMLLTLLVLGMVWVASAIVDKNKANRESLYDFW---- 190

  Fly   193 GSVHLPFLYSCVSFLGVMLMLICTPYGFVRLFGVVNQVLVRPMLLRDVNEEFSAFYMEEASVKRK 257
             ..:||:||||:|||||:|:|:|||.|..|:|.|..::||:|.||.|:.|:......|||::.|:
Human   191 -EYYLPYLYSCISFLGVLLLLVCTPLGLARMFSVTGKLLVKPRLLEDLEEQLYCSAFEEAALTRR 254

  Fly   258 LAH---------IE-LHNVSIADAANGGRLGNRIGLGRGRTFYPQPLLQHSQAHLYQRKAMASDV 312
            :.:         :| ||...:|.......||  :.|.|....:..|          :|.|..|..
Human   255 ICNPTSCWLPLDMELLHRQVLALQTQRVLLG--MWLRRAWDTWVSP----------RRVAPGSRC 307

  Fly   313 DELNDRLRELDSERKELDKLRTSSTFQRTFVYPLAMLLLLFCTAVTILLVVQNTLELLIGIKALP 377
                    .|.:.....:|.|.:|.:||...||||||.||..|.:::|:|..:.|||||...|:|
Human   308 --------LLTASHPCTEKRRKASAWQRNLGYPLAMLCLLVLTGLSVLIVAIHILELLIDEAAMP 364

  Fly   378 LSTRQFALGISSLSKLGPFGAGLEVCLIFYLGATSVVGFYSMPFMRKVCPKRRQTSLPQLMLNCG 442
            ...:..:||..|.||||.|||.::|.|||||..:|||||||.|..|.:.|:...|::.|::.||.
Human   365 RGMQGTSLGQVSFSKLGSFGAVIQVVLIFYLMVSSVVGFYSSPLFRSLRPRWHDTAMTQIIGNCV 429

  Fly   443 FMLVLSSALPLLSRIIGITNFDLLGDFGAIEWLGNFQIVLLYNLVFGTTTALCLANKFTATVRRE 507
            .:||||||||:.||.:|:|.||||||||...|||||.||.|||..|...|.|||...|||.||.|
Human   430 CLLVLSSALPVFSRTLGLTRFDLLGDFGRFNWLGNFYIVFLYNAAFAGLTTLCLVKTFTAAVRAE 494

  Fly   508 L 508
            |
Human   495 L 495

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
lili	NP_651290.1	LMBR1	63..495	CDD:282625	202/446 (45%)
LMBR1L	XP_024304815.1	LMBR1	21..487	CDD:309779	216/492 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165142155
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3722
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H10011
Inparanoid	1	1.050	398	1.000	Inparanoid score	I1956
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48055
OrthoDB	1	1.010	-	-		D334825at33208
OrthoFinder	1	1.000	-	-		FOG0003610
OrthoInspector	1	1.000	-	-		otm41800
orthoMCL	1	0.900	-	-		OOG6_105069
Panther	1	1.100	-	-	LDO	PTHR12625
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2924
SonicParanoid	1	1.000	-	-		X2485
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.800