DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6980 and STI1

DIOPT Version :9

Sequence 1:	NP_651289.1	Gene:	CG6980 / 42955	FlyBaseID:	FBgn0039228	Length:	250	Species:	Drosophila melanogaster
Sequence 2:	NP_014670.1	Gene:	STI1 / 854192	SGDID:	S000005553	Length:	589	Species:	Saccharomyces cerevisiae

Alignment Length:	269	Identity:	65/269 - (24%)
Similarity:	117/269 - (43%)	Gaps:	59/269 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 NEEVKDNAQLKATMLNCNLNPSV--ADDFAE-----FEATLAKIDCIL-----QNKAPCDDEDSK 55
            :|.:|| .||.|.::....||..  .|.|.:     ..|||..:|..:     .|..|.:.|.||
Yeast   152 SEMMKD-PQLVAKLIGYKQNPQAIGQDLFTDPRLMTIMATLMGVDLNMDDINQSNSMPKEPETSK 215

  Fly    56 AGGDAKEKINFDNLDVDKVRLKVKENRTVINRKSLEEDNEKQVKDMNQKSFMEQVEKDANDRAEA 120
            :....|:      .:........|||.:...:|  ||..|.           |.:|.|.:|
Yeast   216 STEQKKD------AEPQSDSTTSKENSSKAPQK--EESKES-----------EPMEVDEDD---- 257

  Fly   121 RAKAEYEAELQRSQGNEAFRSQKYEKAILHYDKAIIKVKDSAITYC-NRALCYIKLQNYKRALKD 184
               ::.||:.::::||:.::::::::||.||:||....||  |||. |||....:...|:.|:..
Yeast   258 ---SKIEADKEKAEGNKFYKARQFDEAIEHYNKAWELHKD--ITYLNNRAAAEYEKGEYETAIST 317

  Fly   185 CQYVLEKLQESNL------RAWLYQAHAYKGL----KQDDKFEESVVKAREHNP----KQLAYID 235
            ....:|:.:|...      :::....:||..|    |..:.:::|:.   ||..    .:|...:
Yeast   318 LNDAVEQGREMRADYKVISKSFARIGNAYHKLGDLKKTIEYYQKSLT---EHRTADILTKLRNAE 379

  Fly   236 KYIKQLEAD 244
            |.:|:.||:
Yeast   380 KELKKAEAE 388

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6980	NP_651289.1	TPR_11	127..190	CDD:290150	20/63 (32%)
		TPR repeat	128..156	CDD:276809	9/27 (33%)
		TPR repeat	161..192	CDD:276809	9/31 (29%)
		TPR_1	162..190	CDD:278916	8/28 (29%)
		TPR repeat	197..225	CDD:276809	5/37 (14%)
STI1	NP_014670.1	PLN03088	5..>106	CDD:215568
		TPR repeat	5..33	CDD:276809
		TPR repeat	39..69	CDD:276809
		TPR repeat	74..102	CDD:276809
		STI1	138..193	CDD:407696	13/41 (32%)
		3a0801s09	203..>573	CDD:273380	51/217 (24%)
		TPR repeat	262..290	CDD:276809	9/27 (33%)
		TPR repeat	294..324	CDD:276809	9/31 (29%)
		TPR repeat	336..363	CDD:276809	4/26 (15%)
		PLN03088	396..>549	CDD:215568
		TPR repeat	396..424	CDD:276809
		TPR repeat	429..459	CDD:276809
		TPR repeat	464..490	CDD:276809
		STI1	527..581	CDD:407696
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0548
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810