DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6980 and CNS1

DIOPT Version :9

Sequence 1:	NP_651289.1	Gene:	CG6980 / 42955	FlyBaseID:	FBgn0039228	Length:	250	Species:	Drosophila melanogaster
Sequence 2:	NP_009713.1	Gene:	CNS1 / 852452	SGDID:	S000000359	Length:	385	Species:	Saccharomyces cerevisiae

Alignment Length:	186	Identity:	50/186 - (26%)
Similarity:	90/186 - (48%)	Gaps:	36/186 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    91 EEDNEKQVKDMNQKSFMEQVEKDANDRA-------EARAKAEYE------AELQRSQGNEAFRSQ 142
            ::.:::.:|:||:..|. ..:.|..|.|       ||.....||      ||..:.||||.::::
Yeast    34 DKTSDEILKEMNRMPFF-MTKLDETDGAGGENVELEALKALAYEGEPHEIAENFKKQGNELYKAK 97

  Fly   143 KYEKAILHYDKAI-IKVKDSAIT---YCNRALCYIKLQNYKRALKDCQYVLEKLQESNLRAWLYQ 203
            :::.|...|.|.: ::.:|.:|.   |.|||.|.::|:||:|.::||...| .:...|::.:...
Yeast    98 RFKDARELYSKGLAVECEDKSINESLYANRAACELELKNYRRCIEDCSKAL-TINPKNVKCYYRT 161

  Fly   204 AHAYKGLKQDDKFEESVVKAREHNPK----------QLAYIDKYIKQLEADLKALE 249
            :.|:..|   :|.||:...|...|.:          .|:.||:    .|.:|||.|
Yeast   162 SKAFFQL---NKLEEAKSAATFANQRIDPENKSILNMLSVIDR----KEQELKAKE 210

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6980	NP_651289.1	TPR_11	127..190	CDD:290150	23/72 (32%)
		TPR repeat	128..156	CDD:276809	9/28 (32%)
		TPR repeat	161..192	CDD:276809	13/33 (39%)
		TPR_1	162..190	CDD:278916	12/30 (40%)
		TPR repeat	197..225	CDD:276809	6/27 (22%)
CNS1	NP_009713.1	3a0801s09	68..>218	CDD:273380	43/151 (28%)
		TPR repeat	83..111	CDD:276809	9/27 (33%)
		TPR repeat	120..150	CDD:276809	12/30 (40%)
		Wheel	257..374	CDD:408742
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R218
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.940