DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6980 and TTC4

DIOPT Version :9

Sequence 1:	NP_651289.1	Gene:	CG6980 / 42955	FlyBaseID:	FBgn0039228	Length:	250	Species:	Drosophila melanogaster
Sequence 2:	NP_004614.3	Gene:	TTC4 / 7268	HGNCID:	12394	Length:	387	Species:	Homo sapiens

Alignment Length:	193	Identity:	51/193 - (26%)
Similarity:	88/193 - (45%)	Gaps:	41/193 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    87 RKSLEEDN-EKQVKDMNQKSFMEQVEKDANDRA-------------EARAKAEYEAELQRSQGNE 137
            |....||. ||:.:.:  ..||.:...:.:.|.             |.|:..| :|:..:.:||:
Human    27 RGGFHEDQWEKEFEKV--PLFMSRAPSEIDPRENPDLACLQSIIFDEERSPEE-QAKTYKDEGND 88

  Fly   138 AFRSQKYEKAILHYDKAI-IKVKD---SAITYCNRALCYIKLQNYKRALKDCQYVLEKLQESNLR 198
            .|:.:.|:||::.|.:.: .|..|   :|:.|.|||.....|.|::.||.|.. ...||:..:|:
Human    89 YFKEKDYKKAVISYTEGLKKKCADPDLNAVLYTNRAAAQYYLGNFRSALNDVT-AARKLKPCHLK 152

  Fly   199 AWLYQAHAYKGLKQDDKFEESV--------VKAREHNPKQL-AYIDKYIKQLE------ADLK 246
            |.:..|..:..||.   |.|:|        :.|:|....:: |..|| :|::|      |:||
Human   153 AIIRGALCHLELKH---FAEAVNWCDEGLQIDAKEKKLLEMRAKADK-LKRIEQRDVRKANLK 211

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6980	NP_651289.1	TPR_11	127..190	CDD:290150	20/66 (30%)
		TPR repeat	128..156	CDD:276809	8/28 (29%)
		TPR repeat	161..192	CDD:276809	10/30 (33%)
		TPR_1	162..190	CDD:278916	10/27 (37%)
		TPR repeat	197..225	CDD:276809	9/35 (26%)
TTC4	NP_004614.3	TPR_11	78..148	CDD:290150	22/70 (31%)
		TPR 1	79..112		9/32 (28%)
		TPR repeat	79..107	CDD:276809	8/27 (30%)
		TPR repeat	116..146	CDD:276809	10/30 (33%)
		TPR 2	117..150		12/33 (36%)
		TPR_16	123..181	CDD:290168	17/61 (28%)
		TPR 3	151..184		9/35 (26%)
		TPR repeat	151..179	CDD:276809	8/30 (27%)
		NinG	173..>236	CDD:283434	10/40 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R218
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.940