Protein Alignment CG6980 and TTC1

DIOPT Version :10

• Sequence 1: NP_651289.1
• Gene: CG6980 / 42955
• FlyBaseID: FBgn0039228
• Length: 250
• Species: Drosophila melanogaster
• Sequence 2: NP_003305.1
• Gene: TTC1 / 7265
• HGNCID: 12391
• Length: 292
• Species: Homo sapiens
• Alignment Length: 232
• Identity: 56/232 - (24%)
• Similarity: 98/232 - (42%)
• Gaps: 52/232 - (22%)

  Fly    27 DDFAEFEATLAKIDCILQNKAPCDDEDSKAGGDAKEKINFDNLDVDKVRLKVKENRTVINRKSLE 91
            ||.|..:....:.:|.....|..::|..                .|||..|..|:   :|...|:
Human    48 DDEAHLQEDQGEEECFHDCSASFEEEPG----------------ADKVENKSNED---VNSSELD 93

  Fly    92 EDNEKQVKDMNQKSFMEQVEKDANDRAEARAKAEYEAELQRSQGNEAFRSQKYEKAILHYDKAII 156
            |:            ::.::||:.:|  |.:.|...|:...:.:|||.|:...|.:|...|.:|:.
Human    94 EE------------YLIELEKNMSD--EEKQKRREESTRLKEEGNEQFKKGDYIEAESSYSRALE 144

  Fly   157 KV-----KDSAITYCNRALCYIKLQNYKRALKDCQYVLEKLQESNLRAWLYQAHAY-KGLKQDDK 215
            ..     |:.:|.:.|||...:|....:.|:.||...:: |..|.:||.|.:|..| |..|.|:.
Human   145 MCPSCFQKERSILFSNRAAARMKQDKKEMAINDCSKAIQ-LNPSYIRAILRRAELYEKTDKLDEA 208

  Fly   216 FEE---------SVVKARE---HNPKQLAYIDKYIKQ 240
            .|:         |:.:|||   ..|||:...::.:|:
Human   209 LEDYKSILEKDPSIHQAREACMRLPKQIEERNERLKE 245

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG6980	NP_651289.1	Spy	117..>233	CDD:443119	38/133 (29%)
		TPR repeat	128..156	CDD:276809	8/27 (30%)
		TPR repeat	161..192	CDD:276809	8/30 (27%)
		TPR repeat	197..225	CDD:276809	11/37 (30%)
TTC1	NP_003305.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	23..125		21/109 (19%)
		NlpI	49..>221	CDD:443815	47/205 (23%)
		TPR 1	116..149		8/32 (25%)
		TPR repeat	119..144	CDD:276809	8/24 (33%)
		TPR repeat	149..184	CDD:276809	9/35 (26%)
		TPR 2	155..188		9/33 (27%)
		TPR 3	189..222		9/32 (28%)
		TPR repeat	189..217	CDD:276809	9/27 (33%)