DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6980 and Ttc12

DIOPT Version :9

Sequence 1:	NP_651289.1	Gene:	CG6980 / 42955	FlyBaseID:	FBgn0039228	Length:	250	Species:	Drosophila melanogaster
Sequence 2:	XP_006243066.1	Gene:	Ttc12 / 300696	RGDID:	1303264	Length:	723	Species:	Rattus norvegicus

Alignment Length:	250	Identity:	74/250 - (29%)
Similarity:	123/250 - (49%)	Gaps:	28/250 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MANEEVKDNAQLKATMLNCNLNPSVADDFAEFEATLAKIDCILQNKAPCDDEDSKAGGDAKEKIN 65
            ||:::.:|   |:..:.|       .|:.......:...|..:|.||..|.|         :|:.
  Rat    20 MADDQERD---LQRFLEN-------VDEITNLIQEMNSDDPFIQQKAVLDTE---------KKLL 65

  Fly    66 FDNLDVDKVRLKVKENRTVINRKSLEEDNEKQVKDMNQKSFMEQVEKDANDRAEARAKAEYEAEL 130
            ....:.::...:...|:|:|:.....|:    ..:||..:|:..|||||.:||:.|.:....|:.
  Rat    66 LMEREQEEDGCRTTLNKTMISPPQAPEN----ANEMNPDAFLASVEKDAKERAKRRRENRVLADA 126

  Fly   131 QRSQGNEAFRSQKYEKAILHYDKAIIKVKDSAITYCNRALCYIKLQNYKRALKDCQYVLEKLQES 195
            .:.:|||||....||.||..|.:.:.|:||..:.|.|||..||||.:|::||.||.:.| |..|:
  Rat   127 LKEKGNEAFVKGDYETAIFFYSEGLGKLKDMKVLYTNRAQAYIKLGDYQKALVDCDWAL-KCDEN 190

  Fly   196 NLRAWLYQAHAYKGLKQDDKFEESVVKAREHNPKQLAYIDKYIKQL----EADLK 246
            ..:|:.:...|:..||...|.:|...|..|.|||..|.:.:::.|:    :|||:
  Rat   191 CTKAYFHMGKAHLALKNYSKSKECYQKIGEINPKLKAQVKEHLNQVTLREKADLQ 245

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6980	NP_651289.1	TPR_11	127..190	CDD:290150	27/62 (44%)
		TPR repeat	128..156	CDD:276809	11/27 (41%)
		TPR repeat	161..192	CDD:276809	14/30 (47%)
		TPR_1	162..190	CDD:278916	13/27 (48%)
		TPR repeat	197..225	CDD:276809	7/27 (26%)
Ttc12	XP_006243066.1	TPR_11	124..189	CDD:290150	29/65 (45%)
		TPR repeat	124..152	CDD:276809	11/27 (41%)
		TPR repeat	157..187	CDD:276809	14/30 (47%)
		TPR_11	160..223	CDD:290150	24/63 (38%)
		TPR_1	161..191	CDD:278916	16/30 (53%)
		TPR repeat	192..217	CDD:276809	6/24 (25%)
		TPR_1	193..224	CDD:278916	9/30 (30%)
		ARM	631..723	CDD:237987
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0548
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0005389
OrthoInspector	1	1.000	-	-		otm44459
orthoMCL	1	0.900	-	-		OOG6_108547
Panther	1	1.100	-	-	LDO	PTHR46540
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.810