DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6980 and Ttc12

DIOPT Version :9

Sequence 1:	NP_651289.1	Gene:	CG6980 / 42955	FlyBaseID:	FBgn0039228	Length:	250	Species:	Drosophila melanogaster
Sequence 2:	NP_766358.1	Gene:	Ttc12 / 235330	MGIID:	2444588	Length:	704	Species:	Mus musculus

Alignment Length:	253	Identity:	73/253 - (28%)
Similarity:	125/253 - (49%)	Gaps:	28/253 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MANEEVKDNAQLKATMLNCNLNPSVADDFAEFEATLAKIDCILQNKAPCDDEDSKAGGDAKEKIN 65
            ||:::.:|   |:..:.|       .|:.......:...|..:|.||..|.|         :|:.
Mouse     1 MADDQERD---LQRFLEN-------VDEITSLIQEMNSDDPFIQQKAVLDSE---------KKLL 46

  Fly    66 FDNLDVDKVRLKVKENRTVINRKSLEEDNEKQVKDMNQKSFMEQVEKDANDRAEARAKAEYEAEL 130
            ....:.::...:...|:|:|:.....|:.:    :|:..:|:..|||||.:||:.|.:....|:.
Mouse    47 LMEREQEEDGCRTTLNKTMISPPQTPENAD----EMSPDAFLASVEKDAKERAKRRRENRVLADA 107

  Fly   131 QRSQGNEAFRSQKYEKAILHYDKAIIKVKDSAITYCNRALCYIKLQNYKRALKDCQYVLEKLQES 195
            .:.:|||||....||.||..|.:.:.|:||..:.|.|||..:|||.:|::||.||.:.| |..|:
Mouse   108 LKEKGNEAFVRGDYETAIFFYSEGLGKLKDMKVLYTNRAQAFIKLGDYQKALVDCDWAL-KCDEN 171

  Fly   196 NLRAWLYQAHAYKGLKQDDKFEESVVKAREHNPKQLAYIDKYIKQL----EADLKALE 249
            ..:|:.:...|:..||...|.:|...|..|.|||..|.:.:::.|:    :|||:..|
Mouse   172 CTKAYFHMGKAHVALKNYSKAKECYQKIEEINPKLKAQVKEHLNQVTLREKADLQEKE 229

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6980	NP_651289.1	TPR_11	127..190	CDD:290150	26/62 (42%)
		TPR repeat	128..156	CDD:276809	11/27 (41%)
		TPR repeat	161..192	CDD:276809	13/30 (43%)
		TPR_1	162..190	CDD:278916	12/27 (44%)
		TPR repeat	197..225	CDD:276809	7/27 (26%)
Ttc12	NP_766358.1	TPR_11	105..170	CDD:290150	28/65 (43%)
		TPR 1	105..138		13/32 (41%)
		TPR repeat	105..133	CDD:276809	11/27 (41%)
		TPR repeat	138..168	CDD:276809	13/30 (43%)
		TPR 2	139..172		15/33 (45%)
		TPR_11	141..204	CDD:290150	23/63 (37%)
		TPR_1	142..172	CDD:278916	15/30 (50%)
		TPR 3	173..206		10/32 (31%)
		TPR repeat	173..198	CDD:276809	6/24 (25%)
		TPR_1	174..205	CDD:278916	9/30 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	54	1.000	Domainoid score	I11152
eggNOG	1	0.900	-	-		E2759_KOG0548
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0005389
OrthoInspector	1	1.000	-	-		otm42394
orthoMCL	1	0.900	-	-		OOG6_108547
Panther	1	1.100	-	-	LDO	PTHR46540
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R218
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	7.840