DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6980 and STIP1

DIOPT Version :9

Sequence 1:	NP_651289.1	Gene:	CG6980 / 42955	FlyBaseID:	FBgn0039228	Length:	250	Species:	Drosophila melanogaster
Sequence 2:	NP_001269581.1	Gene:	STIP1 / 10963	HGNCID:	11387	Length:	590	Species:	Homo sapiens

Alignment Length:	276	Identity:	62/276 - (22%)
Similarity:	109/276 - (39%)	Gaps:	84/276 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    52 EDSKAGGDAKEKINFDNL--DVDKVRLKVKENRTVINRKS---LEEDNEKQVKDMNQKS------ 105
            ::.:.|.||.:|.:||..  ..||.:.....|.|.|..::   .|:.:..:.:::.:|:
Human   274 KEKELGNDAYKKKDFDTALKHYDKAKELDPTNMTYITNQAAVYFEKGDYNKCRELCEKAIEVGRE 338

  Fly   106 -------------------FMEQVEKDA-----NDRAEARA----KAEYEAEL------------ 130
                               |.|:..|||     ...||.|.    |...:||.
Human   339 NREDYRQIAKAYARIGNSYFKEEKYKDAIHFYNKSLAEHRTPDVLKKCQQAEKILKEQERLAYIN 403

  Fly   131 ------QRSQGNEAFRSQKYEKAILHYDKAIIKVKDSAITYCNRALCYIKLQNYKRALKDCQYVL 189
                  ::::|||.|:...|.:|:.||.:||.:....|..|.|||.||.||..::.|||||:..:
Human   404 PDLALEEKNKGNECFQKGDYPQAMKHYTEAIKRNPKDAKLYSNRAACYTKLLEFQLALKDCEECI 468

  Fly   190 EKLQESNLRAWLYQAHAYKGLKQDDKFEESVVKA-----------------------REHNP--- 228
            : |:.:.::.:..:|.|.:.:|...|..:...||                       |..:|
Human   469 Q-LEPTFIKGYTRKAAALEAMKDYTKAMDVYQKALDLDSSCKEAADGYQRCMMAQYNRHDSPEDV 532

  Fly   229 KQLAYIDKYIKQLEAD 244
            |:.|..|..::|:.:|
Human   533 KRRAMADPEVQQIMSD 548

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6980	NP_651289.1	TPR_11	127..190	CDD:290150	26/80 (33%)
		TPR repeat	128..156	CDD:276809	11/45 (24%)
		TPR repeat	161..192	CDD:276809	14/30 (47%)
		TPR_1	162..190	CDD:278916	14/27 (52%)
		TPR repeat	197..225	CDD:276809	6/50 (12%)
STIP1	NP_001269581.1	PLN03088	<54..579	CDD:330826	62/276 (22%)
		TPR repeat	54..79	CDD:276809
		TPR repeat	84..114	CDD:276809
		TPR repeat	119..147	CDD:276809
		TPR repeat	276..300	CDD:276809	8/23 (35%)
		TPR repeat	305..335	CDD:276809	5/29 (17%)
		TPR repeat	347..375	CDD:276809	5/27 (19%)
		TPR repeat	411..435	CDD:276809	9/23 (39%)
		TPR repeat	440..470	CDD:276809	14/30 (47%)
		TPR repeat	475..503	CDD:276809	6/27 (22%)
		TPR repeat	509..538	CDD:276809	4/28 (14%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0548
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810