DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment polybromo and BAZ1B

DIOPT Version :9

Sequence 1:	NP_651288.1	Gene:	polybromo / 42954	FlyBaseID:	FBgn0039227	Length:	1654	Species:	Drosophila melanogaster
Sequence 2:	NP_001357331.1	Gene:	BAZ1B / 9031	HGNCID:	961	Length:	1483	Species:	Homo sapiens

Alignment Length:	1560	Identity:	302/1560 - (19%)
Similarity:	487/1560 - (31%)	Gaps:	592/1560 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly   121 LIGNAKAFYIPGSSEHQDAVSLWQHIHSQRQRIMEANGLAEE-EPRARRMSRQVRRMTSSTEPGG 184
            |.|....|.||               |:|     ||....|| |.|..|.|.::....|:   |.
Human    16 LPGEEPLFTIP---------------HTQ-----EAFRTREEYEARLERYSERIWTCKST---GS 57

  Fly   185 DGATDDEYNQYEELFASVMTATDPVGDRLMHRMFQLLPSKKIYPDYYDVIEHPIDLRLIATKIQM 249
            ...|..|..:.|:..|.::                    |:.:|.:|:        :|:...:..
Human    58 SQLTHKEAWEEEQEVAELL--------------------KEEFPAWYE--------KLVLEMVHH 94

  Fly   250 NAYSSLAEMERDLLQ-MTKNACLFNEPGSQIYKDAKSLKRIFTQRRIELEMGKGKLAKRVKSLSS 313
            |..|....::...|: |||.|                     .....:.|:||.|:.| ||.:..
Human    95 NTASLEKLVDTAWLEIMTKYA---------------------VGEECDFEVGKEKMLK-VKIVKI 137

  Fly   314 AAIAALKEEV-----------DSSDDEETS----------------------------------- 332
            ..:..:.||.           .|||.|.:|
Human   138 HPLEKVDEEATEKKSDGACDSPSSDKENSSQIAQDHQKKETVVKEDEGRRESINDRARRSPRKLP 202

  Fly   333 ---KKGEGPMWA---LFDHLYNAPGTSEHPGVTGPPLGNSLWKLPVRRFHPEYFELIKRPISMSQ 391
               |||| ..||   ...|.|:....:|...::..| .:||    :|...|...|:::..|.
Human   203 TSLKKGE-RKWAPPKFLPHKYDVKLQNEDKIISNVP-ADSL----IRTERPPNKEIVRYFIR--- 258

  Fly   392 IHTKLKKGDYAN------------------ISDLTADLYLML----------------------- 415
             |..|:.|...|                  .||...|.|..:
Human   259 -HNALRAGTGENAPWVVEDELVKKYSLPSKFSDFLLDPYKYMTLNPSTKRKNTGSPDRKPSKKSK 322

  Fly   416 -DNAKKAFPTSHR----TH------KDALKMLKLMNAKLVEESLEEGSDLDDEDAEEMDTEVFTV 469
             ||:..:.|.:.:    .|      ...||:....|:|..||.|||...:  ....::.|.....
Human   323 TDNSSLSSPLNPKLWCHVHLKKSLSGSPLKVKNSKNSKSPEEHLEEMMKM--MSPNKLHTNFHIP 385

  Fly   470 STQPEKRKPG-------RPRINSNSNSNASHTPNNSNSPKSNRIAINAAIKKKILSIQKYLVDYS 527
            ...|..:|||       :.:..|....|...:..||.|||.........:|      |..|:|.:
Human   386 KKGPPAKKPGKHSDKPLKAKGRSKGILNGQKSTGNSKSPKKGLKTPKTKMK------QMTLLDMA 444

  Fly   528 LGNRRPIEMFMEKPPR-------------KIYPDYYDIIQNPIDMNTI----EHNIRTDRYAAVE 575
            .|.::     |.:.||             |..|        |..::.|    |:..|.|:.:|:.
Human   445 KGTQK-----MTRAPRNSGGTPRTSSKPHKHLP--------PAALHLIAYYKENKDREDKRSALS 496

  Fly   576 DVVSDYRLMFSNCRQYNEEGSNIYEDANILERA-LNEKLKEFPGLTEGKKSQQKYSKVGRKLKTA 639
            .|:|....:.|:            ||     || |.|:|:..        .|::|..:..|.:.|
Human   497 CVISKTARLLSS------------ED-----RARLPEELRSL--------VQKRYELLEHKKRWA 536

  Fly   640 VITERLWQFYETVKEYQEPKGKRQLSLIFTKLPSKSEYPDYYDIIREPIDMDRIAQKLKQGAYDT 704
            .::|      |..|||.:.|                              .:.:.:|||:.|.:.
Human   537 SMSE------EQRKEYLKKK------------------------------REELKKKLKEKAKER 565

  Fly   705 LDDLAADFLLMLENACKYNEPDSQIYKDALVLQQLTLQLKQQLR--TERDSLP-----DVPLAVQ 762
            .:   .:.|..||...:|.:            |:||.:.....|  ...:.||     ||.:.|:
Human   566 RE---KEMLERLEKQKRYED------------QELTGKNLPAFRLVDTPEGLPNTLFGDVAMVVE 615

  Fly   763 ELFLTLFTTIYNHQDEEGRCYSDSLAELPEYDEIGEGPKVRGISLDLVKRRLDKGAYKRLDVYQE 827
              ||:              |||..|....:|       .:..:|| :.....|||.:    :|..
Human   616 --FLS--------------CYSGLLLPDAQY-------PITAVSL-MEALSADKGGF----LYLN 652

  Fly   828 DIFACLERARKLSRTDSDIFQDSIELQTYFIRKRDELCKD----TLSSSALNFSLERLMADVELC 888
            .:...|                   |||..   :||:.:|    .:..|.:..:|..:...|.||
Human   653 RVLVIL-------------------LQTLL---QDEIAEDYGELGMKLSEIPLTLHSVSELVRLC 695

  Fly   889 -RQQKMQQEEQDQEQDKEKDEFNAAKGESMTINQQVFSPGDYVYVQMPENKIPSICCIERLWTSP 952
             |:..:|:|.:..:.|..||   :|..|...:..:.                     :|:|.||.
Human   696 LRRSDVQEESEGSDTDDNKD---SAAFEDNEVQDEF---------------------LEKLETSE 736

  Fly   953 ----TNEKLMQ--ASIFVRPHETY----HVTTRKFLEKEVFKSSL-------------------- 987
                |:|:.:|  .::..|...||    |:.||:.:..|::|..|
Human   737 FFELTSEEKLQILTALCHRILMTYSVQDHMETRQQMSAELWKERLAVLKEENDKKRAEKQKRKEM 801

  Fly   988 -SQTISMDKVQ-GMCYVMNIKDYIKMRPENLPEKD--VYVCESR--YNIQGRWFKKLKSWPPVRE 1046
             ::.....||: |:......|:.:|..|:...|.:  :...:||  ..||.:..::::.
Human   802 EAKNKENGKVENGLGKTDRKKEIVKFEPQVDTEAEDMISAVKSRRLLAIQAKKEREIQE------ 860

  Fly  1047 GSSVKFVPREQPLELKRVMSVFKERLEKHKGELEELKLQE-----TLVEKEKPNVSCDPPPNA-- 1104
                    ||..::|:|  ...:||:.|||...|: ..||     .||.:..| :..|...|.
Human   861 --------REMKVKLER--QAEEERIRKHKAAAEK-AFQEGIAKAKLVMRRTP-IGTDRNHNRYW 913

  Fly  1105 ----EVGSTYYQ----------QYNTICSGAIKTGDFVY--------------VATQTGKQSVAQ 1141
                ||...:.:          ::|..|.....:||..|              :.||.|..:...
Human   914 LFSDEVPGLFIEKGWVHDSIDYRFNHHCKDHTVSGDEDYCPRSKKANLGKNASMNTQHGTATEVA 978

  Fly  1142 VQQIWEQNGKSYFKGPWLLPPSE--------------------------------------TTPG 1168
            |:....:.|::.    |.|..|:                                      ..|.
Human   979 VETTTPKQGQNL----WFLCDSQKELDELLNCLHPQGIRESQLKERLEKRYQDIIHSIHLARKPN 1039

  Fly  1169 LGKQFY--RQEL---LLSTVEEVSPVVGIVGRCAVLEYSEFISSRPTEISESDVYICESVYD--E 1226
            ||.:..  .|||   |.|.:.||:..:...|...|.|.|||         |:.|...|.:.|  |
Human  1040 LGLKSCDGNQELLNFLRSDLIEVATRLQKGGLGYVEETSEF---------EARVISLEKLKDFGE 1095

  Fly  1227 LKKAL-----RKLVTGNM------RKFQHSPSVTEDEI----------------FYFKTPIKPSK 1264
            ...||     :|.:.|.|      ||.|...|...:|:                ..:||.|:.::
Human  1096 CVIALQASVIKKFLQGFMAPKQKRRKLQSEDSAKTEEVDEEKKMVEEAKVASALEKWKTAIREAQ 1160

  Fly  1265 DFKNELNELGMLEDSMDGDTPSLSSDIAAMSSPAPSVNSTPLTSKVKAAKSAKK-----CLTG-- 1322
            .|......||||:       ..:..|::|.::............|:.......|     ||..
Human  1161 TFSRMHVLLGMLD-------ACIKWDMSAENARCKVCRKKGEDDKLILCDECNKAFHLFCLRPAL 1218

  Fly  1323 YILYSSEVRKSICQSNPDATFGDISRMVGTEWKNLPSSVKQSWEDRASRQNEETAALRRELDDVQ 1387
            |.:...|.:...||   .||....||  |..:..  .|..:..||..|.:.||......|.:|.:
Human  1219 YEVPDGEWQCPACQ---PATARRNSR--GRNYTE--ESASEDSEDDESDEEEEEEEEEEEEEDYE 1276

Fly 1388 1387
Human 1277 1276

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
polybromo	NP_651288.1	Bromodomain	46..158	CDD:295360	9/36 (25%)
		Bromo_polybromo_II	191..294	CDD:99948	14/103 (14%)
		Bromo_polybromo_III	335..443	CDD:99951	29/162 (18%)
		Bromo_polybromo_IV	512..613	CDD:99949	25/118 (21%)
		Bromo_polybromo_V	641..733	CDD:99946	14/91 (15%)
		Bromo_polybromo_VI	758..867	CDD:99956	20/108 (19%)
		BAH_polybromo	921..1040	CDD:240068	27/154 (18%)
		BAH_polybromo	1120..1234	CDD:240068	34/177 (19%)
		HMG-box	1320..1375	CDD:238037	14/56 (25%)
BAZ1B	NP_001357331.1	WAC_Acf1_DNA_bd	21..120	CDD:337781	30/170 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	145..212		11/67 (16%)
		C motif	207..213		3/6 (50%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	302..333		3/30 (10%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	379..432		12/52 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	446..470		4/28 (14%)
		DDT	604..668	CDD:214726	22/113 (19%)
		DUF5401	<664..>877	CDD:340095	49/252 (19%)
		WHIM1	727..767	CDD:339506	11/60 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	788..817		3/28 (11%)
		WSD	898..1025	CDD:317927	18/131 (14%)
		PHD_BAZ1B	1186..1231	CDD:277098	6/44 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1237..1326		11/44 (25%)
		Bromo_WSTF_like	1344..1440	CDD:99937
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1455..1483
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5076
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810