DRSC/TRiP Functional Genomics Resources

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Protein Alignment polybromo and KAT2B

DIOPT Version :9

Sequence 1:NP_651288.1 Gene:polybromo / 42954 FlyBaseID:FBgn0039227 Length:1654 Species:Drosophila melanogaster
Sequence 2:NP_003875.3 Gene:KAT2B / 8850 HGNCID:8638 Length:832 Species:Homo sapiens


Alignment Length:770 Identity:153/770 - (19%)
Similarity:254/770 - (32%) Gaps:234/770 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly   131 PGSSEHQDAVSLWQHI----HSQRQRIMEANGLAEEEPRARRMSR------QVRRMTSSTEPGGD 185
            |.:...|..|||.:..    |:....:.....::|||     |:|      .|..:.:......|
Human   121 PRADLQQIIVSLTESCRSCSHALAAHVSHLENVSEEE-----MNRLLGIVLDVEYLFTCVHKEED 180

  Fly   186 GATDDEY-NQYEELFASVMTATDPVGDRLMHR-------------------MFQLLPSK------ 224
            ..|...| ..::.|..|::....||.:..:.:                   .|..||:|      
Human   181 ADTKQVYFYLFKLLRKSILQRGKPVVEGSLEKKPPFEKPSIEQGVNNFVQYKFSHLPAKERQTIV 245

  Fly   225 ---KIYPD--YYDVIEHPIDLRLIATKIQMNAYSSLAEMERDLLQMTKNACLFNEP--------- 275
               |::.:  .|..:|.|...||.:....::.|..         ..|:..|..|.|         
Human   246 ELAKMFLNRINYWHLEAPSQRRLRSPNDDISGYKE---------NYTRWLCYCNVPQFCDSLPRY 301

  Fly   276 -GSQIYKDAKSLKRIFTQRRIEL------EMGKGKLAKRVKSLS--SAAIAALKEEVDS------ 325
             .:|:: ....|:.:||..|.:|      |..|..|.||...|:  ...::.|:|||.|      
Human   302 ETTQVF-GRTLLRSVFTVMRRQLLEQARQEKDKLPLEKRTLILTHFPKFLSMLEEEVYSQNSPIW 365

  Fly   326 -----SDDEETSKKG------EGPMWALFDHLYNAPGTS-EHP--GVTGPPL-------GNSLWK 369
                 |....||:.|      ..|:.....  ||:..:| |.|  |.:.|..       .|...|
Human   366 DQDFLSASSRTSQLGIQTVINPPPVAGTIS--YNSTSSSLEQPNAGSSSPACKASSGLEANPGEK 428

  Fly   370 LPVRRFHPEYFELIKRPISMSQIHTKLKKGDYANISDLTADLYLMLDNAKKAFPTSHRTHKDALK 434
            ..:...|  ..|..|:|..|..|..:|.....:.|:|..|.|     ..:..|.::|....:|.:
Human   429 RKMTDSH--VLEEAKKPRVMGDIPMELINEVMSTITDPAAML-----GPETNFLSAHSARDEAAR 486

  Fly   435 MLK---LMNAKLVEESLEEG------------SDLDDEDAEEMDTEVFT-VSTQPEKR-----KP 478
            :.:   ::...:|..||.:.            .::.......|..|..| :...|:.:     |.
Human   487 LEERRGVIEFHVVGNSLNQKPNKKILMWLVGLQNVFSHQLPRMPKEYITRLVFDPKHKTLALIKD 551

  Fly   479 GRP--------------------RINSNS--NSNASHTPNNSNSPKSNRIAINAAIKKKILSIQK 521
            ||.                    .:.||.  ....:|..|:..         ...||..||:...
Human   552 GRVIGGICFRMFPSQGFTEIVFCAVTSNEQVKGYGTHLMNHLK---------EYHIKHDILNFLT 607

  Fly   522 YLVDYSLGNRRPIEMFME-KPPRKIYPDYYDIIQNPIDMNTIEHNIRTDRYAAVEDVVSDYR--- 582
            |..:|::|..:......| |.|:..|..|                            :.||.   
Human   608 YADEYAIGYFKKQGFSKEIKIPKTKYVGY----------------------------IKDYEGAT 644

  Fly   583 LMFSNCR-----QYNEEGSNIYEDANILERALNEK----LKEFPGL------------------- 619
            ||  .|.     .|.|....|.:...|:::.:..|    .|.:|||                   
Human   645 LM--GCELNPRIPYTEFSVIIKKQKEIIKKLIERKQAQIRKVYPGLSCFKDGVRQIPIESIPGIR 707

  Fly   620 -TEGKKSQQKYSKVGRKLKTAVITERLWQFYETVKEYQEPKGKRQLSLIFTKLPSKSEYPDYYDI 683
             |..|.|.::.||..|...         |.|.|:|...:.....|.:..|.:...::|.|.||::
Human   708 ETGWKPSGKEKSKEPRDPD---------QLYSTLKSILQQVKSHQSAWPFMEPVKRTEAPGYYEV 763

  Fly   684 IREPIDMDRIAQKLKQGAYDTLDDLAADFLLMLENACKYNEPDSQIYKDALVLQQ 738
            ||.|:|:..::::||...|.:.....||...:..|..:||.|:|:.||.|.:|::
Human   764 IRFPMDLKTMSERLKNRYYVSKKLFMADLQRVFTNCKEYNPPESEYYKCANILEK 818

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
polybromoNP_651288.1 Bromodomain 46..158 CDD:295360 6/30 (20%)
Bromo_polybromo_II 191..294 CDD:99948 24/143 (17%)
Bromo_polybromo_III 335..443 CDD:99951 25/126 (20%)
Bromo_polybromo_IV 512..613 CDD:99949 22/113 (19%)
Bromo_polybromo_V 641..733 CDD:99946 26/91 (29%)
Bromo_polybromo_VI 758..867 CDD:99956
BAH_polybromo 921..1040 CDD:240068
BAH_polybromo 1120..1234 CDD:240068
HMG-box 1320..1375 CDD:238037
KAT2BNP_003875.3 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..54
PCAF_N 75..325 CDD:368925 40/218 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 395..436 10/44 (23%)
COG5076 487..826 CDD:227408 74/380 (19%)
Acetyl-CoA binding. /evidence=ECO:0000269|PubMed:10393169 574..576 0/1 (0%)
Acetyl-CoA binding. /evidence=ECO:0000269|PubMed:10393169 581..587 0/5 (0%)
Acetyl-CoA binding. /evidence=ECO:0000269|PubMed:10393169 612..615 1/2 (50%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 706..725 6/18 (33%)
Bromo_gcn5_like 727..826 CDD:99941 28/92 (30%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5076
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.900

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