DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment polybromo and YPL216W

DIOPT Version :9

Sequence 1:	NP_651288.1	Gene:	polybromo / 42954	FlyBaseID:	FBgn0039227	Length:	1654	Species:	Drosophila melanogaster
Sequence 2:	NP_015108.1	Gene:	YPL216W / 855885	SGDID:	S000006137	Length:	1102	Species:	Saccharomyces cerevisiae

Alignment Length:	1260	Identity:	236/1260 - (18%)
Similarity:	415/1260 - (32%)	Gaps:	398/1260 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   373 RRFHPEYFELIKRPISMSQIHTKLKKGDYANISDLTADLYLMLDNAKKAFPTSHRTHKDALKMLK 437
            |:..|:  |:.:...|.|:....:|:.. ..|:|..:|| ..||..|:...|...:.||.|...|
Yeast     7 RKIQPK--EIGQSADSFSETPWVIKESS-ERINDYDSDL-KKLDFYKRDIFTCEISGKDGLSYFK 67

  Fly   438 LMNAKLVEESLEEGSDLDDEDAEEMDTEVFTVSTQPEKRKPGRPRINSNSNSNASHTPNNSNSPK 502
            .:.                  :||...|........|.||......|.:......|...::....
Yeast    68 ALK------------------SEEQHREKVRYLLPKELRKAIANFANFSPIRKVGHLVESAFQRF 114

  Fly   503 SNRIAINAAIKKKILSIQK-YLVDYSLGNRRPIEMFMEKPPRKIYPDYYDIIQNPIDMNTIEHNI 566
            |||..|...:..|  :||| .|:.|..|          :|         :::::|    |||:|:
Yeast   115 SNRFFIGDTVCLK--TIQKNALITYKEG----------EP---------NLVESP----TIENNV 154

  Fly   567 RTDRYAAVEDVVSDYRLMFSNCRQYNEEGSNIYEDANILERALNEKLKE---FPGLTEGKKSQQK 628
               ....|:||.....:|.|...:.:....::|    ::...||.:.|.   ..|..|.|:.:..
Yeast   155 ---TLFLVKDVFQSNGMMESEKGEISAPKLSLY----LITECLNRESKGAALIVGQNEIKRPESH 212

  Fly   629 YSKVGRKLKTAVITERL----------WQF-YETVKEYQ-EPK-GKRQLSLIFTKLPSKSE---- 676
            :||.   :....:.|.|          |:. .|.::.|. .|| ....:..:..::.|.|.
Yeast   213 FSKF---IIACFLNEILIKVSNKEHAPWRVKQEYIERYDVNPKCSPNMIDYLPDRMNSSSSELYT 274

  Fly   677 ---YPDYYDIIREPID----------------------------MDRIAQKLKQGAYD----TLD 706
               .|...|:  ||.|                            .|.|...:...||:    |:|
Yeast   275 PLTIPPESDV--EPADWKETSETSETSETSLSKIKAIDDEISVSFDHIYDNVNSLAYNDLKGTVD 337

  Fly   707 DLAADF---------LLMLENACKYNEPDSQIYKDALVLQQLTLQLKQQLRTERDSLPDVPLAVQ 762
            |....|         :..|:::.:|...|.:.:|:.           .|..|||       |.|.
Yeast   338 DKELPFTGPSIPFENISYLDSSLEYKNIDQKWFKEC-----------SQFPTER-------LLVV 384

  Fly   763 ELFLTLF---------------TTIYNHQDEEGRCYSDSLAELPEYDEIGEGPKVRGISLDLVKR 812
            ..||:.|               |||        :|.|.. |.:.||           :.::.:|.
Yeast   385 YQFLSFFGRFIGLSHFNFDQFLTTI--------KCTSPE-ALVDEY-----------VKINFLKT 429

  Fly   813 RLDKGAY----KRLDVYQEDIFACLERARKLSRTDSD------------------IFQDSIELQT 855
            ...||::    .|.::|.:...:.:.:..|.:..::|                  |...|.|...
Yeast   430 YNSKGSFTNEKPRNEIYNQVTSSNVSQREKANVFNADESQRIPSNFTRNQKMRKFITDKSTEFVM 494

  Fly   856 YFIRKRDELCKDTLSSSALNFSLERLMADVELCRQQKMQQEEQDQE--------QDKEKDEFNAA 912
            |.|.|...|..|.:...:.. .:..|..|:.......|...|.|..        ::|.|:|.|
Yeast   495 YSIFKGKPLKNDDMEFQSYE-KVNILYIDIVCSLMCLMTDNEPDWNCNLMDNWTEEKRKEEGN-- 556

  Fly   913 KGESMTINQQVFSPGDYVYVQMPENKIPS----ICCIERLWTSPTNEKLMQASIFVRPHETYHVT 973
            |.|.....::..:.||..:|::..||..|    :.|:..:        |.|.:..:...:.....
Yeast   557 KTEIDIAIEKCLNYGDTSWVKLLHNKNFSNGNWLICLLGI--------LQQNTHMIAYSDVAKCI 613

  Fly   974 TRKFLEKEV------------FKSSLSQTISMDKVQGMC----YVMNIKDYIKMRPENLPEKDVY 1022
            |:|.|...:            |:..||   ..||:..:.    :..|...|||...:.:|:
Yeast   614 TKKILPLSMNFVNLGDELWDNFRKRLS---IKDKIDVLWVLVDFASNFSSYIKELVDKVPK---- 671

  Fly  1023 VCESRYNIQGRWFKKLKSWPPVREGSSVKF-VPREQPLELKR-VMSVFKERLEKH---------- 1075
            :|                     .|..:|. ..:::.::||| :.::.|.|::.|
Yeast   672 LC---------------------NGIRLKLDSAKKEYIKLKRQLKTLTKNRVKLHSNVSMNRYGS 715

  Fly  1076 ---KGELEELK-----LQETLVEKEKPNVSCDPPPNAEV------GSTYYQQYNTICSGAIKTGD 1126
               ||::..||     |.|.:...|...:..| ....|:      |:.||...:...|.||...:
Yeast   716 DECKGKVNALKVKIAYLMEDIAFLEAKLIQSD-IKRLEILGKDRNGNRYYWMDSNGSSSAISEKN 779

  Fly  1127 -------FVYVATQTGKQSVAQVQQIWEQNGKSYFKGPW-LLPPSETTPGLGKQFYRQELLLSTV 1183
                   |::|.    ..|.|.:....:.:.:|..|  | ||..::.|....|:.:  .:..||.
Yeast   780 EELYNCCFLWVQ----GPSEADINFCLDVDVESLKK--WELLAKAKGTAYATKEVF--SIFRSTD 836

  Fly  1184 EEVSPVV-----------GIVGRCAVLEY--SEFISSRPTEISES-----------DVYICESVY 1224
            .....:.           ||:.|..:..:  .:.||..|.::..|           |:::.....
Yeast   837 GSYYQIAQGENFMIINSNGILMRPTIPAFIDKKIISETPEKLLLSHHQWAFFNDIEDIHMLVDRL 901

  Fly  1225 DELKK---ALRKLVTGNMRKFQHSPSVTEDEIFYFKTPIKPSKDFK--------NELN--ELGML 1276
            |:|::   .|:|.:|..|.:.:    |:..:.|..|..|:..:.||        ||..  ||..:
Yeast   902 DDLRENEGQLKKALTSKMDRIE----VSYKQQFKIKRRIECDETFKKNHKLLKNNEFTFPELKRI 962

  Fly  1277 EDSMDGDTPSLSSDIAAMSSPAPSVNSTPLTSKVKAAKSAKKCLTGYILYSSEVRKSICQSNPDA 1341
            |.:...:....|             |...::.|:...|:.        |....:.|.:      |
Yeast   963 ETTCTSNGQHFS-------------NMEKISKKLSRTKND--------LVLEAILKDV------A 1000

  Fly  1342 TFGDISRMVGTEWKNLPSSVKQSWEDRASRQNE---ETAALRRE--------------LDDVQNS 1389
            ..|:..|.:..:.:||...:...:|...:...|   ||...|:|              :..|...
Yeast  1001 HLGECERALLKKQQNLIYPLNFHFEQLRTIDLEFIVETKRKRQEDILTKLLNHQRYKHISHVSGY 1065

  Fly  1390 ASPSSQVSQ----DVFGQVLTFECQ 1410
            ...|.:|.:    ||.|.:...|||
Yeast  1066 GISSQRVDKAAHLDVQGILEEIECQ 1090

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
polybromo	NP_651288.1	Bromodomain	46..158	CDD:295360
		Bromo_polybromo_II	191..294	CDD:99948
		Bromo_polybromo_III	335..443	CDD:99951	18/69 (26%)
		Bromo_polybromo_IV	512..613	CDD:99949	21/101 (21%)
		Bromo_polybromo_V	641..733	CDD:99946	26/152 (17%)
		Bromo_polybromo_VI	758..867	CDD:99956	27/145 (19%)
		BAH_polybromo	921..1040	CDD:240068	23/138 (17%)
		BAH_polybromo	1120..1234	CDD:240068	26/148 (18%)
		HMG-box	1320..1375	CDD:238037	9/57 (16%)
YPL216W	NP_015108.1	WAC_Acf1_DNA_bd	26..124	CDD:287503	25/117 (21%)
		DDT	375..435	CDD:214726	19/86 (22%)
		WHIM1	626..667	CDD:292246	9/43 (21%)
		WHIM2	750..793	CDD:292247	9/46 (20%)
		WHIM3	885..923	CDD:292248	7/37 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5076
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900